Ensembl ID ENSG00000128383 Gene ID 200315 Accession 17343
Gene Symbol APOBEC3A Alias A3A;ARP3;PHRBN;bK150C2.1 Full Name apolipoprotein B mRNA editing enzyme catalytic subunit 3A
Position 22 : 38952751 - 38992778 Length 40028 bases Strand Plus strand
Status Confidence Main interacting RNAsN.A.RBP type Canonical_RBPs
Summary This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. The protein encoded by this gene lacks the zinc binding activity of other family members. The protein plays a role in immunity, by restricting transmission of foreign DNA such as viruses. One mechanism of foreign DNA restriction is deamination of foreign double-stranded DNA cytidines to uridines, which leads to DNA degradation. However, other mechanisms are also thought to be involved, as anti-viral effect is not dependent on deaminase activity. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2012]

ENSG00000128383 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000128383 1.17 2.69e-14 KIRC
ENSG00000128383 1.53 5.05e-16 BRCA
ENSG00000128383 -2.7 8.93e-28 COAD
ENSG00000128383 -1.8 1.96e-14 LIHC
ENSG00000128383 -1.3 8.42e-11 LUAD
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000128383 cancer 21368204
ENSG00000128383 cancer 22977230
ENSG00000128383 breast cancers 23599896
ENSG00000128383 breast cancer 23715497
ENSG00000128383 cancer 23840298
ENSG00000128383 tumor 23950602
ENSG00000128383 cancer 23977391
ENSG00000128383 skin cancer 23979356
ENSG00000128383 breast cancer 24728294
ENSG00000128383 Tumor 25085003
ENSG00000128383 cancer 25237741
ENSG00000128383 bladder cancer 25281661
ENSG00000128383 cancer 25298230
ENSG00000128383 tumor 25401976
ENSG00000128383 pancreatic cancer 25502777
ENSG00000128383 cancer 25807502
ENSG00000128383 cancers 25898173
ENSG00000128383 breast cancer 26097867
ENSG00000128383 cancers 26258849
ENSG00000128383 breast cancer 26320772
ENSG00000128383 cervical cancer 26379844
ENSG00000128383 cancer 26489798
ENSG00000128383 breast cancers 26682542
ENSG00000128383 cancers 26755635
ENSG00000128383 cancer 26832400
ENSG00000128383 tumors 26918916
ENSG00000128383 breast cancer 26920143
ENSG00000128383 oral cancers 27155849
ENSG00000128383 tumor 27283319
ENSG00000128383 breast cancer 27552096
ENSG00000128383 breast cancer 27634334
ENSG00000128383 bladder cancer 27643540
ENSG00000128383 tumours 27650891
ENSG00000128383 oropharyngeal cancers 27694899
ENSG00000128383 cancer 27716362
ENSG00000128383 breast cancer 27730215
ENSG00000128383 tumors 27858943
ENSG00000128383 cancer 27940951
ENSG00000128383 breast cancer 28062980
ENSG00000128383 cancer 28100701
ENSG00000128383 cancer 28117753
ENSG00000128383 tumor 28405512
ENSG00000128383 cancer 28439266
ENSG00000128383 AML 28655787
ENSG00000128383 Cancer 28698210
ENSG00000128383 cancers 28825669
ENSG00000128383 cancer 28878238
ENSG00000128383 cancer 28981865
ENSG00000128383 breast cancer 29100317
ENSG00000128383 HNSCC 29103756
ENSG00000128383 breast cancer 29116104
ENSG00000128383 cancer 29140415
ENSG00000128383 tumor 29166639
ENSG00000128383 cancer 29367246
ENSG00000128383 bladder cancer 29435122
ENSG00000128383 cancer 29642934
ENSG00000128383 tumors 29856501
ENSG00000128383 oropharyngeal cancers 29950685
ENSG00000128383 cancers 29963239
ENSG00000128383 cancer 30233553
ENSG00000128383 Tumor 30348839
ENSG00000128383 cancers 30417129
ENSG00000128383 tumor 30418757
ENSG00000128383 gastric cancer 30431097
ENSG00000128383 gastric cancers 30514953
ENSG00000128383 cancers 30591678
ENSG00000128383 cancers 30619092
ENSG00000128383 tumours 30624727
ENSG00000128383 cancer 30679716
ENSG00000128383 cancer 30719225
ENSG00000128383 cancer 30759888
ENSG00000128383 tumors 30840888
ENSG00000128383 cancers 30849372
ENSG00000128383 tumors 30980272
ENSG00000128383 tumour 31019223
ENSG00000128383 cancers 31200452
ENSG00000128383 cancer 31249028
ENSG00000128383 Cancer 31285296
ENSG00000128383 cancers 31392335
ENSG00000128383 tumors 31431505
ENSG00000128383 cancers 31533728
ENSG00000128383 tumor 31544853
ENSG00000128383 cancer 31568516
ENSG00000128383 cancer 31726973
ENSG00000128383 breast cancer 31841499
ENSG00000128383 breast cancer 31930332
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000128383 MESO 0.004 low
ENSG00000128383 SARC 0.048 low
ENSG00000128383 UVM 0.017 high
ENSG00000128383 PAAD 0.0077 high
ENSG00000128383 UCEC 0.0048 high
ENSG00000128383 LGG 0.013 high
ENSG00000128383 HNSC 0.0011 low
ENSG00000128383 THYM 0.02 high
ENSG00000128383 BRCA 0.0068 low
ENSG00000128383 UCS 0.029 low
ENSG00000128383 OV 0.0018 low
ENSG00000128383 DLBC 0.0079 low
ENSG00000128383 KIRC 0.0053 high
ENSG00000128383 TGCT 0.00065 low
ENSG00000128383 GBM 0.041 high
ENSG00000128383 SKCM 0.00017 low
ENSG00000128383 CESC 0.0014 low
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000128383 THYM Del 1.199597 0.051052 0.435240 0.138211
ENSG00000128383 SKCM Amp 2.409128 0.173180 0.598678 0.384196