Ensembl ID ENSG00000128050 Gene ID 10606 Accession 8587
Gene Symbol PAICS Alias ADE2;AIRC;PAIS;ADE2H1;PAICSD Full Name phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase
Position 4 : 56435741 - 56464578 Length 28838 bases Strand Plus strand
Status Confidence Main interacting RNAsN.A.RBP type Non-canonical_RBPs
Summary This gene encodes a bifunctional enzyme containing phosphoribosylaminoimidazole carboxylase activity in its N-terminal region and phosphoribosylaminoimidazole succinocarboxamide synthetase in its C-terminal region. It catalyzes steps 6 and 7 of purine biosynthesis. The gene is closely linked and divergently transcribed with a locus that encodes an enzyme in the same pathway, and transcription of the two genes is coordinately regulated. The human genome contains several pseudogenes of this gene. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

ENSG00000128050 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000128050 PAICS 0.99 1.99e-56 BRCA
ENSG00000128050 PAICS 1.26 2.22e-46 COAD
ENSG00000128050 PAICS 2.22 3.65e-90 LUSC
ENSG00000128050 PAICS 0.69 1.58e-20 PRAD
ENSG00000128050 PAICS 1.06 5.75e-18 STAD
ENSG00000128050 PAICS 0.85 1.58e-17 UCEC
ENSG00000128050 PAICS 1.85 3.27e-84 LUAD
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000128050 PAICS Cancer 10098428
ENSG00000128050 PAICS cancer 17224163
ENSG00000128050 PAICS tumour 18420266
ENSG00000128050 PAICS cancer 18680205
ENSG00000128050 PAICS tumor 21845230
ENSG00000128050 PAICS cancer 23394948
ENSG00000128050 PAICS tumor 23717670
ENSG00000128050 PAICS cancer 24555823
ENSG00000128050 PAICS cancer 25078523
ENSG00000128050 PAICS cancer 25869206
ENSG00000128050 PAICS lung cancer 26140362
ENSG00000128050 PAICS Cancer 27030157
ENSG00000128050 PAICS Cancer 27184434
ENSG00000128050 PAICS prostate cancer 27514314
ENSG00000128050 PAICS Prostate Cancer 27550065
ENSG00000128050 PAICS cancer 28152521
ENSG00000128050 PAICS breast cancer 28411283
ENSG00000128050 PAICS Colorectal Cancer 29456503
ENSG00000128050 PAICS cancer 29491720
ENSG00000128050 PAICS prostate cancer 29744932
ENSG00000128050 PAICS prostate cancer 29750539
ENSG00000128050 PAICS breast cancer 30097015
ENSG00000128050 PAICS tumor 30121007
ENSG00000128050 PAICS Wilms tumor 30550360
ENSG00000128050 PAICS tumor 30641222
ENSG00000128050 PAICS Cancer 30669702
ENSG00000128050 PAICS Cancer 30997669
ENSG00000128050 PAICS DLBCL 31331250
ENSG00000128050 PAICS tumor 31624245
ENSG00000128050 PAICS Breast Cancer 3806161
ENSG00000128050 PAICS prostate cancer 9101208
ENSG00000128050 PAICS tumours 9554755
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000128050 PAICS MESO 0.0028 high
ENSG00000128050 PAICS SARC 0.00012 high
ENSG00000128050 PAICS CHOL 0.01 high
ENSG00000128050 PAICS UCEC 0.017 low
ENSG00000128050 PAICS THCA 0.00025 high
ENSG00000128050 PAICS ACC 0.031 high
ENSG00000128050 PAICS HNSC 0.0022 high
ENSG00000128050 PAICS READ 0.0099 low
ENSG00000128050 PAICS KICH 0.0012 high
ENSG00000128050 PAICS PCPG 0.018 high
ENSG00000128050 PAICS THYM 0.017 low
ENSG00000128050 PAICS BRCA 0.0013 high
ENSG00000128050 PAICS COAD 0.048 low
ENSG00000128050 PAICS ESCA 0.04 high
ENSG00000128050 PAICS OV 0.0027 low
ENSG00000128050 PAICS DLBC 0.0059 low
ENSG00000128050 PAICS KIRC 0.0011 high
ENSG00000128050 PAICS SKCM 0.0019 high
ENSG00000128050 PAICS CESC 0.012 low
ENSG00000128050 PAICS LIHC 3e-04 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000128050 PAICS LUSC Amp 6.013561 0.326160 0.708933 0.211577
ENSG00000128050 PAICS LGG Amp 5.934576 0.110456 1.360958 0.040936
ENSG00000128050 PAICS GBM Amp 15.155945 0.248853 1.213575 0.100520
ENSG00000128050 PAICS TGCT Amp 6.761908 0.332628 1.095097 0.126667