Ensembl ID ENSG00000128050 Gene ID 10606 Accession 8587
Gene Symbol PAICS Alias ADE2;AIRC;PAIS;ADE2H1;PAICSD Full Name phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase
Position 4 : 56435741 - 56464578 Length 28838 bases Strand Plus strand
Status Confidence Main interacting RNAsN.A.RBP type Non-canonical_RBPs
Summary This gene encodes a bifunctional enzyme containing phosphoribosylaminoimidazole carboxylase activity in its N-terminal region and phosphoribosylaminoimidazole succinocarboxamide synthetase in its C-terminal region. It catalyzes steps 6 and 7 of purine biosynthesis. The gene is closely linked and divergently transcribed with a locus that encodes an enzyme in the same pathway, and transcription of the two genes is coordinately regulated. The human genome contains several pseudogenes of this gene. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

ENSG00000128050 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000128050 0.99 1.99e-56 BRCA
ENSG00000128050 1.26 2.22e-46 COAD
ENSG00000128050 2.22 3.65e-90 LUSC
ENSG00000128050 0.69 1.58e-20 PRAD
ENSG00000128050 1.06 5.75e-18 STAD
ENSG00000128050 0.85 1.58e-17 UCEC
ENSG00000128050 1.85 3.27e-84 LUAD
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000128050 Cancer 10098428
ENSG00000128050 cancer 17224163
ENSG00000128050 tumour 18420266
ENSG00000128050 cancer 18680205
ENSG00000128050 tumor 21845230
ENSG00000128050 cancer 23394948
ENSG00000128050 tumor 23717670
ENSG00000128050 cancer 24555823
ENSG00000128050 cancer 25078523
ENSG00000128050 cancer 25869206
ENSG00000128050 lung cancer 26140362
ENSG00000128050 Cancer 27030157
ENSG00000128050 Cancer 27184434
ENSG00000128050 prostate cancer 27514314
ENSG00000128050 Prostate Cancer 27550065
ENSG00000128050 cancer 28152521
ENSG00000128050 breast cancer 28411283
ENSG00000128050 Colorectal Cancer 29456503
ENSG00000128050 cancer 29491720
ENSG00000128050 prostate cancer 29744932
ENSG00000128050 prostate cancer 29750539
ENSG00000128050 breast cancer 30097015
ENSG00000128050 tumor 30121007
ENSG00000128050 Wilms tumor 30550360
ENSG00000128050 tumor 30641222
ENSG00000128050 Cancer 30669702
ENSG00000128050 Cancer 30997669
ENSG00000128050 DLBCL 31331250
ENSG00000128050 tumor 31624245
ENSG00000128050 Breast Cancer 3806161
ENSG00000128050 prostate cancer 9101208
ENSG00000128050 tumours 9554755
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000128050 MESO 0.0028 high
ENSG00000128050 SARC 0.00012 high
ENSG00000128050 CHOL 0.01 high
ENSG00000128050 UCEC 0.017 low
ENSG00000128050 THCA 0.00025 high
ENSG00000128050 ACC 0.031 high
ENSG00000128050 HNSC 0.0022 high
ENSG00000128050 READ 0.0099 low
ENSG00000128050 KICH 0.0012 high
ENSG00000128050 PCPG 0.018 high
ENSG00000128050 THYM 0.017 low
ENSG00000128050 BRCA 0.0013 high
ENSG00000128050 COAD 0.048 low
ENSG00000128050 ESCA 0.04 high
ENSG00000128050 OV 0.0027 low
ENSG00000128050 DLBC 0.0059 low
ENSG00000128050 KIRC 0.0011 high
ENSG00000128050 SKCM 0.0019 high
ENSG00000128050 CESC 0.012 low
ENSG00000128050 LIHC 3e-04 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000128050 LUSC Amp 6.013561 0.326160 0.708933 0.211577
ENSG00000128050 LGG Amp 5.934576 0.110456 1.360958 0.040936
ENSG00000128050 GBM Amp 15.155945 0.248853 1.213575 0.100520
ENSG00000128050 TGCT Amp 6.761908 0.332628 1.095097 0.126667