Ensembl ID ENSG00000127603 Gene ID 23499 Accession 13664
Gene Symbol MACF1 Alias ACF7;LIS9;MACF;OFC4;ABP620;KIAA0754;Lnc-PMIF Full Name microtubule actin crosslinking factor 1
Position 1 : 39081316 - 39487177 Length 405862 bases Strand Plus strand
Status Confidence Main interacting RNAsN.A.RBP type Non-canonical_RBPs
Summary This gene encodes a large protein containing numerous spectrin and leucine-rich repeat (LRR) domains. The encoded protein is a member of a family of proteins that form bridges between different cytoskeletal elements. This protein facilitates actin-microtubule interactions at the cell periphery and couples the microtubule network to cellular junctions. Alternative splicing results in multiple transcript variants, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, May 2013]

ENSG00000127603 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000127603 -1.5 4.54e-43 LUSC
ENSG00000127603 -1.3 1.68e-31 UCEC
ENSG00000127603 -0.9 1.82e-18 LUAD
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000127603 tumour 16316396
ENSG00000127603 cancer 22584905
ENSG00000127603 cancers 24622401
ENSG00000127603 breast cancers 25041824
ENSG00000127603 colorectal cancer 25974029
ENSG00000127603 cancer 26154152
ENSG00000127603 cancer 26521939
ENSG00000127603 brain tumors 27959385
ENSG00000127603 cancer 28577926
ENSG00000127603 malignant tumor 28673583
ENSG00000127603 cancers 28782898
ENSG00000127603 cancer 29351916
ENSG00000127603 cancer 29373494
ENSG00000127603 breast cancer 29386124
ENSG00000127603 Cancer 29587367
ENSG00000127603 cancer 30065750
ENSG00000127603 cancer 31427592
ENSG00000127603 bladder tumors 31737111
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000127603 SARC 0.036 low
ENSG00000127603 CHOL 0.0043 low
ENSG00000127603 UVM 0.0031 high
ENSG00000127603 UCEC 0.012 high
ENSG00000127603 ACC 0.00016 high
ENSG00000127603 LGG 3e-04 high
ENSG00000127603 HNSC 0.0058 low
ENSG00000127603 READ 0.018 low
ENSG00000127603 KICH 0.0041 high
ENSG00000127603 LUAD 0.0037 low
ENSG00000127603 THYM 0.018 high
ENSG00000127603 BLCA 0.018 high
ENSG00000127603 LAML 0.0027 low
ENSG00000127603 GBM 0.026 low
ENSG00000127603 SKCM 0.019 low
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000127603 CHOL Del 1.952817 0.306751 0.620861 0.305556
ENSG00000127603 LUAD Amp 1.395977 0.135540 0.429291 0.265504
ENSG00000127603 KIRP Del 1.053942 0.030450 0.601674 0.138889
ENSG00000127603 ESCA Amp 1.127896 0.288176 0.739427 0.201087
ENSG00000127603 LIHC Del 3.192837 0.101242 0.507670 0.300000
ENSG00000127603 PCPG Del 1.424006 0.073513 0.673502 0.623457
ENSG00000127603 BLCA Amp 6.657611 0.325044 0.762918 0.230392
ENSG00000127603 UCEC Amp 1.542272 0.123447 0.574117 0.122449
ENSG00000127603 UVM Del 1.628635 0.096085 0.809086 0.300000
ENSG00000127603 OV Amp 26.129103 0.774889 0.841659 0.504318