Ensembl ID ENSG00000127022 Gene ID 821 Accession 1473
Gene Symbol CANX Alias CNX;P90;IP90 Full Name calnexin
Position 5 : 179678628 - 179731641 Length 53014 bases Strand Plus strand
Status Confidence Main interacting RNAsN.A.RBP type Canonical_RBPs
Summary This gene encodes a member of the calnexin family of molecular chaperones. The encoded protein is a calcium-binding, endoplasmic reticulum (ER)-associated protein that interacts transiently with newly synthesized N-linked glycoproteins, facilitating protein folding and assembly. It may also play a central role in the quality control of protein folding by retaining incorrectly folded protein subunits within the ER for degradation. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jun 2018]

ENSG00000127022 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000127022 CANX 0.49 7.40e-12 KIRC
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000127022 CANX tumor 10933198
ENSG00000127022 CANX cervical cancer 11713591
ENSG00000127022 CANX breast cancer 11726208
ENSG00000127022 CANX tumor 14732231
ENSG00000127022 CANX tumour 15478216
ENSG00000127022 CANX tumor 15958569
ENSG00000127022 CANX cancer 16098126
ENSG00000127022 CANX astrocytic tumors 16322289
ENSG00000127022 CANX tumour 17353921
ENSG00000127022 CANX astrocytic tumors 17545629
ENSG00000127022 CANX tumor 19674965
ENSG00000127022 CANX tumour 19689735
ENSG00000127022 CANX acute myeloid leukemia (AML) 19708569
ENSG00000127022 CANX brain tumors 20209053
ENSG00000127022 CANX breast cancers 22065046
ENSG00000127022 CANX breast cancer 22355776
ENSG00000127022 CANX tumor 24039668
ENSG00000127022 CANX cervical cancer 24523623
ENSG00000127022 CANX breast cancer 24785274
ENSG00000127022 CANX Tumours 24800053
ENSG00000127022 CANX lung cancer 25004236
ENSG00000127022 CANX GBM 25252179
ENSG00000127022 CANX tumor 26334999
ENSG00000127022 CANX lung cancer 26344721
ENSG00000127022 CANX breast cancer 27129972
ENSG00000127022 CANX tumor 27240165
ENSG00000127022 CANX rectal cancer 27369741
ENSG00000127022 CANX colorectal cancer 27459847
ENSG00000127022 CANX Cancer 27470515
ENSG00000127022 CANX cancer 27846717
ENSG00000127022 CANX tumor 28216622
ENSG00000127022 CANX GBM 30233358
ENSG00000127022 CANX tumor 30401678
ENSG00000127022 CANX breast cancer 31422285
ENSG00000127022 CANX tumor 31638563
ENSG00000127022 CANX lung cancer 31664930
ENSG00000127022 CANX HNSCC 31795200
ENSG00000127022 CANX tumors 31816951
ENSG00000127022 CANX cancer 9299453
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000127022 CANX UVM 8e-04 high
ENSG00000127022 CANX PAAD 0.0017 high
ENSG00000127022 CANX THCA 0.00063 high
ENSG00000127022 CANX LUSC 0.025 high
ENSG00000127022 CANX HNSC 0.011 high
ENSG00000127022 CANX THYM 0.025 low
ENSG00000127022 CANX BRCA 0.014 high
ENSG00000127022 CANX COAD 0.00014 low
ENSG00000127022 CANX ESCA 0.00044 high
ENSG00000127022 CANX OV 0.022 low
ENSG00000127022 CANX LAML 0.0043 low
ENSG00000127022 CANX SKCM 0.0015 low
ENSG00000127022 CANX CESC 0.0058 high
ENSG00000127022 CANX LIHC 0.0056 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000127022 CANX LGG Del 4.195406 0.069644 0.406751 0.111111
ENSG00000127022 CANX KIRP Amp 0.969852 0.061208 0.634107 0.125000
ENSG00000127022 CANX ACC Amp 1.636341 0.383640 1.198372 0.677778
ENSG00000127022 CANX SKCM Del 1.747804 0.082895 0.479053 0.297003
ENSG00000127022 CANX HNSC Del 2.423171 0.072384 0.396179 0.373563
ENSG00000127022 CANX LIHC Amp 2.571713 0.158754 0.574361 0.354054
ENSG00000127022 CANX BLCA Del 1.669719 0.093405 0.399768 0.477941
ENSG00000127022 CANX KIRC Amp 59.407579 0.324820 0.550725 0.625000