Ensembl ID ENSG00000126524 Gene ID 51119 Accession 19440
Gene Symbol SBDS Alias SDS;SDO1;SWDS;CGI-97 Full Name SBDS ribosome maturation factor
Position 7 : 66987680 - 66995693 Length 8014 bases Strand Minus strand
Status Confidence Main interacting RNAsrRNARBP type Canonical_RBPs
Summary This gene encodes a highly conserved protein that plays an essential role in ribosome biogenesis. The encoded protein interacts with elongation factor-like GTPase 1 to disassociate eukaryotic initiation factor 6 from the late cytoplasmic pre-60S ribosomal subunit allowing assembly of the 80S subunit. Mutations within this gene are associated with the autosomal recessive disorder Shwachman-Bodian-Diamond syndrome. This gene has a closely linked pseudogene that is distally located. [provided by RefSeq, Jan 2017]

ENSG00000126524 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000126524 SBDS -1.2 1.32e-21 BLCA
ENSG00000126524 SBDS -0.8 1.73e-78 BRCA
ENSG00000126524 SBDS -0.8 6.40e-20 LUSC
ENSG00000126524 SBDS -0.5 1.09e-25 PRAD
ENSG00000126524 SBDS -1.2 1.19e-32 UCEC
ENSG00000126524 SBDS -0.8 1.03e-30 LUAD
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000126524 SBDS pancreatic cancer 18437680
ENSG00000126524 SBDS AML 19222471
ENSG00000126524 SBDS cancer 19602484
ENSG00000126524 SBDS prostate cancer 19893039
ENSG00000126524 SBDS cervical cancer 20979173
ENSG00000126524 SBDS cancer 21124213
ENSG00000126524 SBDS tumor 24905602
ENSG00000126524 SBDS thyroid cancer 27010584
ENSG00000126524 SBDS AML 28056084
ENSG00000126524 SBDS tumor 30792990
ENSG00000126524 SBDS breast cancer 31853379
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
ENSG00000126524 SBDS female breast carcinoma missense_variant 0.5115% (2/391) 1 entry
ENSG00000126524 SBDS colorectal adenocarcinoma missense_variant 0.6151% (7/1138) 1 entry
ENSG00000126524 SBDS lung adenocarcinoma missense_variant 0.4098% (5/1220) 2 entries
ENSG00000126524 SBDS melanoma missense_variant 0.9901% (1/101) 1 entry
ENSG00000126524 SBDS adrenal cortex carcinoma stop_gained 0.6098% (1/164) 1 entry
ENSG00000126524 SBDS head and neck squamous cell carcinoma missense_variant 0.134% (1/746) 1 entry
ENSG00000126524 SBDS cecum adenocarcinoma sequence_alteration 0.7634% (1/131) 1 entry
ENSG00000126524 SBDS prostate carcinoma missense_variant 0.2066% (1/484) 1 entry
ENSG00000126524 SBDS colon adenocarcinoma sequence_alteration 0.1328% (1/753) 1 entry
ENSG00000126524 SBDS ovarian serous adenocarcinoma missense_variant 0.1486% (1/673) 1 entry
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000126524 SBDS MESO 0.044 high
ENSG00000126524 SBDS SARC 0.0043 low
ENSG00000126524 SBDS STAD 0.017 high
ENSG00000126524 SBDS CHOL 0.015 low
ENSG00000126524 SBDS UVM 0.021 high
ENSG00000126524 SBDS PAAD 0.0085 high
ENSG00000126524 SBDS UCEC 0.0016 high
ENSG00000126524 SBDS LGG 0.0013 high
ENSG00000126524 SBDS LUSC 0.049 low
ENSG00000126524 SBDS HNSC 0.00026 high
ENSG00000126524 SBDS READ 0.038 high
ENSG00000126524 SBDS KIRP 0.028 high
ENSG00000126524 SBDS KICH 0.04 high
ENSG00000126524 SBDS LUAD 0.011 high
ENSG00000126524 SBDS PCPG 0.0032 high
ENSG00000126524 SBDS THYM 0.0063 high
ENSG00000126524 SBDS BRCA 0.00067 high
ENSG00000126524 SBDS ESCA 0.015 high
ENSG00000126524 SBDS OV 0.018 high
ENSG00000126524 SBDS BLCA 0.0077 high
ENSG00000126524 SBDS GBM 0.0028 high
ENSG00000126524 SBDS SKCM 0.0056 low
ENSG00000126524 SBDS CESC 0.0062 high
ENSG00000126524 SBDS LIHC 0.039 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000126524 SBDS KIRP Amp 1.259300 0.072420 0.903267 0.611111
ENSG00000126524 SBDS GBM Amp 1.168574 0.076660 0.790172 0.824957
ENSG00000126524 SBDS TGCT Amp 0.658729 0.114169 0.534135 0.806667
ENSG00000126524 SBDS STAD Amp 0.836135 0.135310 0.505130 0.435374