Ensembl ID ENSG00000126457 Gene ID 3276 Accession 5187
Gene Symbol PRMT1 Alias ANM1;HCP1;IR1B4;HRMT1L2 Full Name protein arginine methyltransferase 1
Position 19 : 49675786 - 49688450 Length 12665 bases Strand Plus strand
Status Confidence Main interacting RNAsN.A.RBP type Canonical_RBPs
Summary This gene encodes a member of the protein arginine N-methyltransferase (PRMT) family. Post-translational modification of target proteins by PRMTs plays an important regulatory role in many biological processes, whereby PRMTs methylate arginine residues by transferring methyl groups from S-adenosyl-L-methionine to terminal guanidino nitrogen atoms. The encoded protein is a type I PRMT and is responsible for the majority of cellular arginine methylation activity. Increased expression of this gene may play a role in many types of cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 5. [provided by RefSeq, Dec 2011]

ENSG00000126457 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000126457 0.58 1.45e-21 BRCA
ENSG00000126457 1.28 4.10e-20 COAD
ENSG00000126457 0.95 1.50e-30 LUSC
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000126457 breast cancer 11097842
ENSG00000126457 breast cancer 15525597
ENSG00000126457 breast cancer 17848568
ENSG00000126457 cancer 17891136
ENSG00000126457 tumour 19078953
ENSG00000126457 cancer 19085993
ENSG00000126457 breast cancer 19170758
ENSG00000126457 breast cancer 19183483
ENSG00000126457 colon cancer 19414388
ENSG00000126457 cancer 19596784
ENSG00000126457 cancers 20473859
ENSG00000126457 cancer 21083602
ENSG00000126457 breast cancer 21229402
ENSG00000126457 cancer 21417440
ENSG00000126457 cancer 21440447
ENSG00000126457 cancer 21838253
ENSG00000126457 cancer 21966347
ENSG00000126457 breast cancer 22095282
ENSG00000126457 cancer 22266372
ENSG00000126457 cancer 22532369
ENSG00000126457 cancers 22748424
ENSG00000126457 cancers 22839530
ENSG00000126457 endometrial cancer 22876322
ENSG00000126457 tumor 22917032
ENSG00000126457 breast cancer 23187807
ENSG00000126457 lung cancer 23202904
ENSG00000126457 cancer 23977297
ENSG00000126457 lung cancer 24211191
ENSG00000126457 tumor 24296620
ENSG00000126457 cancer 24358983
ENSG00000126457 acute myeloid leukemia (AML) 24415537
ENSG00000126457 tumors 24564570
ENSG00000126457 cancers 25559100
ENSG00000126457 breast cancer 25605249
ENSG00000126457 cancer 25847239
ENSG00000126457 tumor 25947404
ENSG00000126457 cancer 25970731
ENSG00000126457 tumor 26045981
ENSG00000126457 cancer 26392112
ENSG00000126457 cancer 26428871
ENSG00000126457 cancer 26460953
ENSG00000126457 gastric cancer 26472729
ENSG00000126457 tumor 26503212
ENSG00000126457 cancer 26563484
ENSG00000126457 colorectal cancer 26571394
ENSG00000126457 tumors 26575292
ENSG00000126457 Tumor 26657730
ENSG00000126457 cancer 26762411
ENSG00000126457 cancer 26766589
ENSG00000126457 cancer 26813495
ENSG00000126457 breast cancer 26934120
ENSG00000126457 tumor 27175582
ENSG00000126457 cancer 27545444
ENSG00000126457 breast cancers 27556302
ENSG00000126457 tumors 27571165
ENSG00000126457 AML 27593928
ENSG00000126457 cancers 27642082
ENSG00000126457 colorectal cancer 28040436
ENSG00000126457 cancers 28231732
ENSG00000126457 tumor 28338320
ENSG00000126457 cancers 28591869
ENSG00000126457 cancers 28636189
ENSG00000126457 triple-negative breast cancer 28643125
ENSG00000126457 Cancer 28655788
ENSG00000126457 oral cancer 28656289
ENSG00000126457 breast cancer 28698590
ENSG00000126457 breast cancer 28733251
ENSG00000126457 cancer 28927791
ENSG00000126457 gastric cancer 29097184
ENSG00000126457 cancer 29113301
ENSG00000126457 cancer 29177029
ENSG00000126457 ER+ Breast Cancers 29262329
ENSG00000126457 liver cancer 29383172
ENSG00000126457 cancers 29535867
ENSG00000126457 tumor 29568320
ENSG00000126457 breast cancer 29683372
ENSG00000126457 cancer 29727702
ENSG00000126457 tumor 29868478
ENSG00000126457 tumour 29945155
ENSG00000126457 tumor 30100758
ENSG00000126457 Pancreatic Cancer 30194893
ENSG00000126457 tumors 30236171
ENSG00000126457 skin cancer 30305303
ENSG00000126457 GBM 30347783
ENSG00000126457 cancers 30352814
ENSG00000126457 tumors 30383835
ENSG00000126457 colon cancer 30569144
ENSG00000126457 tumors 30602621
ENSG00000126457 cancer 30679275
ENSG00000126457 breast cancer 30692633
ENSG00000126457 lung cancer 30736843
ENSG00000126457 oral cancer 30741995
ENSG00000126457 cancer 30826432
ENSG00000126457 breast cancer 30849541
ENSG00000126457 pancreatic cancer 30916320
ENSG00000126457 Breast Cancer 31015230
ENSG00000126457 tumour 31043582
ENSG00000126457 tumor 31061124
ENSG00000126457 Cancer 31287990
ENSG00000126457 cancer 31390828
ENSG00000126457 cancers 31395602
ENSG00000126457 cancers 31478263
ENSG00000126457 pancreatic cancer 31520395
ENSG00000126457 liver tumors 31607134
ENSG00000126457 tumors 31655611
ENSG00000126457 DLBCL 31681423
ENSG00000126457 cancer 31685892
ENSG00000126457 pancreatic cancer 31792888
ENSG00000126457 tumor 31853216
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000126457 SARC 0.00067 high
ENSG00000126457 UVM 0.044 high
ENSG00000126457 PAAD 0.01 low
ENSG00000126457 THCA 0.043 low
ENSG00000126457 ACC 0.0057 high
ENSG00000126457 LGG 0.016 high
ENSG00000126457 HNSC 0.031 high
ENSG00000126457 KIRP 0.014 high
ENSG00000126457 LUAD 0.0043 high
ENSG00000126457 PCPG 0.04 high
ENSG00000126457 THYM 0.038 high
ENSG00000126457 BRCA 0.025 low
ENSG00000126457 COAD 0.045 low
ENSG00000126457 UCS 0.011 high
ENSG00000126457 ESCA 0.013 high
ENSG00000126457 TGCT 0.039 low
ENSG00000126457 BLCA 0.0049 low
ENSG00000126457 GBM 0.034 high
ENSG00000126457 SKCM 0.00089 high
ENSG00000126457 CESC 0.0098 low
ENSG00000126457 LIHC 0.00018 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000126457 LUSC Del 3.654738 0.100702 0.365765 0.281437
ENSG00000126457 LUAD Del 2.762138 0.074694 0.319327 0.368217
ENSG00000126457 LGG Del 16.729021 0.138022 0.663720 0.502924
ENSG00000126457 CESC Del 0.853750 0.070464 0.416877 0.115254
ENSG00000126457 SARC Del 2.880867 0.176931 0.446573 0.322957
ENSG00000126457 GBM Del 11.057979 0.131719 0.503408 0.166378
ENSG00000126457 PAAD Del 0.704455 0.045307 0.291729 0.114130
ENSG00000126457 UCEC Del 0.796201 0.049011 0.456755 0.111317
ENSG00000126457 OV Del 14.106969 0.336575 0.568826 0.514680