Ensembl ID ENSG00000126351 Gene ID 7067 Accession 11796
Gene Symbol THRA Alias AR7;EAR7;ERBA;CHNG6;ERBA1;NR1A1;THRA1;THRA2;c-erbA;ERB-T-1;TRalpha;THRalpha;TRalpha1;TRalpha2;c-ERBA-1;THRalpha1;THRalpha2 Full Name thyroid hormone receptor alpha
Position 17 : 40058290 - 40093867 Length 35578 bases Strand Plus strand
Status Confidence Main interacting RNAsN.A.RBP type Non-canonical_RBPs
Summary The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

ENSG00000126351 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000126351 THRA -0.4 8.45e-13 KIRC
ENSG00000126351 THRA -1.7 5.11e-17 BLCA
ENSG00000126351 THRA -0.8 7.82e-25 BRCA
ENSG00000126351 THRA -1.1 1.08e-32 LUSC
ENSG00000126351 THRA -0.5 1.33e-16 PRAD
ENSG00000126351 THRA -1.5 3.35e-24 UCEC
ENSG00000126351 THRA -0.9 3.01e-25 LUAD
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000126351 THRA thyroid cancer 11705861
ENSG00000126351 THRA gastric cancer 11741739
ENSG00000126351 THRA tumor 11776784
ENSG00000126351 THRA thyroid cancer 12231529
ENSG00000126351 THRA tumor 12668276
ENSG00000126351 THRA non-small cell lung cancer 12911822
ENSG00000126351 THRA cancer 15650025
ENSG00000126351 THRA tumor 1568230
ENSG00000126351 THRA Thyroid cancer 15767343
ENSG00000126351 THRA cancer 1679528
ENSG00000126351 THRA AML 1701231
ENSG00000126351 THRA benign tumor 17929121
ENSG00000126351 THRA thyroid cancer 19519176
ENSG00000126351 THRA breast cancers 1976118
ENSG00000126351 THRA breast cancer 21288332
ENSG00000126351 THRA TGCT 21541616
ENSG00000126351 THRA colorectal cancers 21556591
ENSG00000126351 THRA tumors 21573529
ENSG00000126351 THRA bone tumors 23199169
ENSG00000126351 THRA breast cancer 23628726
ENSG00000126351 THRA thyroid cancer 23781307
ENSG00000126351 THRA breast cancer 23805307
ENSG00000126351 THRA tumors 25098819
ENSG00000126351 THRA breast cancer 25542270
ENSG00000126351 THRA breast cancer 25934412
ENSG00000126351 THRA breast cancer 26029931
ENSG00000126351 THRA GBM 26457500
ENSG00000126351 THRA tumour 26476797
ENSG00000126351 THRA tumor 27633254
ENSG00000126351 THRA invasive breast cancer 28583788
ENSG00000126351 THRA renal cancer 29022645
ENSG00000126351 THRA cancers 29065888
ENSG00000126351 THRA Breast Cancer 30410118
ENSG00000126351 THRA breast cancer 7511052
ENSG00000126351 THRA ovarian cancer 8460637
ENSG00000126351 THRA tumours 8630282
ENSG00000126351 THRA tumour 8692204
ENSG00000126351 THRA tumour 9143412
ENSG00000126351 THRA breast cancer 9695977
ENSG00000126351 THRA tumors 9816013
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000126351 THRA MESO 0.00063 low
ENSG00000126351 THRA UVM 0.0092 low
ENSG00000126351 THRA PAAD 0.011 low
ENSG00000126351 THRA UCEC 0.028 low
ENSG00000126351 THRA ACC 0.0073 low
ENSG00000126351 THRA READ 0.0098 low
ENSG00000126351 THRA KIRP 0.0028 low
ENSG00000126351 THRA PCPG 0.011 low
ENSG00000126351 THRA BRCA 0.012 high
ENSG00000126351 THRA UCS 0.024 low
ENSG00000126351 THRA OV 0.042 high
ENSG00000126351 THRA PRAD 0.0028 low
ENSG00000126351 THRA BLCA 0.0031 high
ENSG00000126351 THRA LAML 0.0015 low
ENSG00000126351 THRA GBM 0.0085 low
ENSG00000126351 THRA SKCM 0.0056 high
ENSG00000126351 THRA LIHC 0.00063 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000126351 THRA ACC Del 2.594385 0.167209 0.584608 0.255556
ENSG00000126351 THRA COAD Amp 8.558979 0.191518 0.653028 0.248337
ENSG00000126351 THRA SARC Del 0.934741 0.128486 0.443780 0.260700
ENSG00000126351 THRA PAAD Amp 0.633560 0.078312 0.470626 0.152174
ENSG00000126351 THRA ESCA Amp 8.264330 0.604173 0.881820 0.391304
ENSG00000126351 THRA PCPG Del 3.706757 0.112943 0.642182 0.216049
ENSG00000126351 THRA BRCA Amp 65.760292 0.639733 1.227074 0.279630
ENSG00000126351 THRA BRCA Del 1.595069 0.071475 0.419986 0.270370
ENSG00000126351 THRA STAD Amp 31.869641 0.624263 1.011558 0.297052
ENSG00000126351 THRA UCEC Amp 5.772628 0.193446 1.047589 0.094620
ENSG00000126351 THRA UCEC Del 1.530597 0.058451 0.562371 0.176252