Ensembl ID
ENSG00000125977
Gene ID
8894
Accession
3266
Gene Symbol
EIF2S2
Alias
EIF2;EIF2B;PPP1R67;EIF2beta;eIF-2-beta
Full Name
eukaryotic translation initiation factor 2 subunit beta
Position
20 : 34088309 - 34112243
Length
23935 bases
Strand
Minus strand
Status
Confidence
Main interacting RNAs tRNA RBP type
Canonical_RBPs
Summary
Eukaryotic translation initiation factor 2 (EIF-2) functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA and binding to a 40S ribosomal subunit. EIF-2 is composed of three subunits, alpha, beta, and gamma, with the protein encoded by this gene representing the beta subunit. The beta subunit catalyzes the exchange of GDP for GTP, which recycles the EIF-2 complex for another round of initiation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]
ENSG00000125977 Expression In 33 Tumors
Ensembl ID
Gene symbol
Log2 Foldchange
Pvaue
Cancer
ENSG00000125977
EIF2S2
0.52
8.31e-22
BRCA
ENSG00000125977
EIF2S2
1.10
2.72e-37
COAD
ENSG00000125977
EIF2S2
1.12
3.78e-11
READ
ENSG00000125977
EIF2S2
0.71
3.05e-24
LUSC
Ensembl ID
Gene symbol
Cancer types
Pubmed ID
ENSG00000125977
EIF2S2
testicular cancer
19168544
ENSG00000125977
EIF2S2
breast tumors
25151356
ENSG00000125977
EIF2S2
cancers
28852147
ENSG00000125977
EIF2S2
non-small cell lung cancer
29624814
ENSG00000125977
EIF2S2
tumors
30538549
Ensembl ID
Gene symbol
Disease/phenotype
Mutation type
Mutated / Total samples
Literature
Ensembl ID
Gene symbol
Cancer
P-value
Which worse
show
ENSG00000125977
EIF2S2
MESO
0.013
high
show
ENSG00000125977
EIF2S2
SARC
4e-04
high
show
ENSG00000125977
EIF2S2
STAD
0.018
low
show
ENSG00000125977
EIF2S2
UVM
0.0075
high
show
ENSG00000125977
EIF2S2
PAAD
0.0043
high
show
ENSG00000125977
EIF2S2
UCEC
0.00077
high
show
ENSG00000125977
EIF2S2
ACC
0.00053
high
show
ENSG00000125977
EIF2S2
LGG
0.002
high
show
ENSG00000125977
EIF2S2
HNSC
0.0013
high
show
ENSG00000125977
EIF2S2
READ
0.0033
low
show
ENSG00000125977
EIF2S2
KICH
0.00069
high
show
ENSG00000125977
EIF2S2
LUAD
0.0028
high
show
ENSG00000125977
EIF2S2
PCPG
0.002
high
show
ENSG00000125977
EIF2S2
THYM
0.00095
low
show
ENSG00000125977
EIF2S2
BRCA
0.013
high
show
ENSG00000125977
EIF2S2
UCS
0.036
high
show
ENSG00000125977
EIF2S2
ESCA
0.0054
high
show
ENSG00000125977
EIF2S2
OV
0.013
low
show
ENSG00000125977
EIF2S2
KIRC
0.00011
high
show
ENSG00000125977
EIF2S2
PRAD
0.00029
low
show
ENSG00000125977
EIF2S2
BLCA
0.049
high
show
ENSG00000125977
EIF2S2
GBM
0.024
low
show
ENSG00000125977
EIF2S2
SKCM
0.00058
low
show
Ensembl ID
Gene symbol
Cancer
CNV type
-log10(q-value)
G-score
average amplitude
frequency
ENSG00000125977
EIF2S2
CESC
Amp
1.847321
0.173707
0.683251
0.440678
ENSG00000125977
EIF2S2
READ
Amp
19.505748
0.663738
1.314692
0.884848
ENSG00000125977
EIF2S2
COAD
Amp
33.610701
0.443548
1.152566
0.720621
ENSG00000125977
EIF2S2
HNSC
Amp
4.798678
0.200091
0.593377
0.434866
ENSG00000125977
EIF2S2
BLCA
Amp
2.365357
0.220856
0.565591
0.629902
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