Ensembl ID ENSG00000125977 Gene ID 8894 Accession 3266
Gene Symbol EIF2S2 Alias EIF2;EIF2B;PPP1R67;EIF2beta;eIF-2-beta Full Name eukaryotic translation initiation factor 2 subunit beta
Position 20 : 34088309 - 34112243 Length 23935 bases Strand Minus strand
Status Confidence Main interacting RNAstRNARBP type Canonical_RBPs
Summary Eukaryotic translation initiation factor 2 (EIF-2) functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA and binding to a 40S ribosomal subunit. EIF-2 is composed of three subunits, alpha, beta, and gamma, with the protein encoded by this gene representing the beta subunit. The beta subunit catalyzes the exchange of GDP for GTP, which recycles the EIF-2 complex for another round of initiation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]

ENSG00000125977 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000125977 EIF2S2 0.52 8.31e-22 BRCA
ENSG00000125977 EIF2S2 1.10 2.72e-37 COAD
ENSG00000125977 EIF2S2 1.12 3.78e-11 READ
ENSG00000125977 EIF2S2 0.71 3.05e-24 LUSC
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000125977 EIF2S2 testicular cancer 19168544
ENSG00000125977 EIF2S2 breast tumors 25151356
ENSG00000125977 EIF2S2 cancers 28852147
ENSG00000125977 EIF2S2 non-small cell lung cancer 29624814
ENSG00000125977 EIF2S2 tumors 30538549
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000125977 EIF2S2 MESO 0.013 high
ENSG00000125977 EIF2S2 SARC 4e-04 high
ENSG00000125977 EIF2S2 STAD 0.018 low
ENSG00000125977 EIF2S2 UVM 0.0075 high
ENSG00000125977 EIF2S2 PAAD 0.0043 high
ENSG00000125977 EIF2S2 UCEC 0.00077 high
ENSG00000125977 EIF2S2 ACC 0.00053 high
ENSG00000125977 EIF2S2 LGG 0.002 high
ENSG00000125977 EIF2S2 HNSC 0.0013 high
ENSG00000125977 EIF2S2 READ 0.0033 low
ENSG00000125977 EIF2S2 KICH 0.00069 high
ENSG00000125977 EIF2S2 LUAD 0.0028 high
ENSG00000125977 EIF2S2 PCPG 0.002 high
ENSG00000125977 EIF2S2 THYM 0.00095 low
ENSG00000125977 EIF2S2 BRCA 0.013 high
ENSG00000125977 EIF2S2 UCS 0.036 high
ENSG00000125977 EIF2S2 ESCA 0.0054 high
ENSG00000125977 EIF2S2 OV 0.013 low
ENSG00000125977 EIF2S2 KIRC 0.00011 high
ENSG00000125977 EIF2S2 PRAD 0.00029 low
ENSG00000125977 EIF2S2 BLCA 0.049 high
ENSG00000125977 EIF2S2 GBM 0.024 low
ENSG00000125977 EIF2S2 SKCM 0.00058 low
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000125977 EIF2S2 CESC Amp 1.847321 0.173707 0.683251 0.440678
ENSG00000125977 EIF2S2 READ Amp 19.505748 0.663738 1.314692 0.884848
ENSG00000125977 EIF2S2 COAD Amp 33.610701 0.443548 1.152566 0.720621
ENSG00000125977 EIF2S2 HNSC Amp 4.798678 0.200091 0.593377 0.434866
ENSG00000125977 EIF2S2 BLCA Amp 2.365357 0.220856 0.565591 0.629902