Ensembl ID ENSG00000125755 Gene ID 8189 Accession 22935
Gene Symbol SYMPK Alias SPK;SYM;Pta1 Full Name symplekin scaffold protein
Position 19 : 45815410 - 45863194 Length 47785 bases Strand Minus strand
Status Confidence Main interacting RNAsmRNARBP type Canonical_RBPs
Summary This gene encodes a nuclear protein that functions in the regulation of polyadenylation and promotes gene expression. The protein forms a high-molecular weight complex with components of the polyadenylation machinery. It is thought to serve as a scaffold for recruiting regulatory factors to the polyadenylation complex. It also participates in 3'-end maturation of histone mRNAs, which do not undergo polyadenylation. The protein also localizes to the cytoplasmic plaques of tight junctions in some cell types. [provided by RefSeq, Jul 2008]

ENSG00000125755 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000125755 SYMPK 0.49 1.57e-23 BRCA
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000125755 SYMPK tumor 20823274
ENSG00000125755 SYMPK tumors 21938678
ENSG00000125755 SYMPK colon cancer 28295283
ENSG00000125755 SYMPK colorectal cancer 28630428
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000125755 SYMPK MESO 0.002 high
ENSG00000125755 SYMPK UVM 0.00014 low
ENSG00000125755 SYMPK PAAD 0.01 low
ENSG00000125755 SYMPK HNSC 0.014 low
ENSG00000125755 SYMPK KIRP 0.043 low
ENSG00000125755 SYMPK PCPG 0.0092 low
ENSG00000125755 SYMPK THYM 0.0049 low
ENSG00000125755 SYMPK UCS 0.044 high
ENSG00000125755 SYMPK OV 0.048 high
ENSG00000125755 SYMPK KIRC 0.00016 high
ENSG00000125755 SYMPK LAML 0.05 high
ENSG00000125755 SYMPK GBM 0.011 low
ENSG00000125755 SYMPK SKCM 0.014 low
ENSG00000125755 SYMPK LIHC 0.0047 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000125755 SYMPK LUSC Del 2.792723 0.092058 0.359261 0.271457
ENSG00000125755 SYMPK LUAD Del 2.245104 0.069869 0.308722 0.341085
ENSG00000125755 SYMPK LGG Del 16.502142 0.136967 0.662275 0.502924
ENSG00000125755 SYMPK SARC Del 2.701218 0.173140 0.471203 0.307393
ENSG00000125755 SYMPK GBM Del 9.305601 0.121212 0.536630 0.149047
ENSG00000125755 SYMPK PAAD Amp 0.825534 0.085759 0.447980 0.206522
ENSG00000125755 SYMPK DLBC Amp 1.440518 0.261726 0.903627 0.145833
ENSG00000125755 SYMPK UCEC Amp 0.829460 0.106360 0.736636 0.115028
ENSG00000125755 SYMPK OV Del 11.471649 0.313576 0.574914 0.492228