Ensembl ID ENSG00000125482 Gene ID 7270 Accession 12397
Gene Symbol TTF1 Alias TTF-1;TTF-I Full Name transcription termination factor 1
Position 9 : 132375548 - 132406851 Length 31304 bases Strand Minus strand
Status Confidence Main interacting RNAsN.A.RBP type Non-canonical_RBPs
Summary This gene encodes a transcription termination factor that is localized to the nucleolus and plays a critical role in ribosomal gene transcription. The encoded protein mediates the termination of RNA polymerase I transcription by binding to Sal box terminator elements downstream of pre-rRNA coding regions. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. This gene shares the symbol/alias 'TFF1' with another gene, NK2 homeobox 1, also known as thyroid transcription factor 1, which plays a role in the regulation of thyroid-specific gene expression. [provided by RefSeq, Apr 2011]

ENSG00000125482 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000125482 TTF1 thyroid tumors 10981870
ENSG00000125482 TTF1 cancer 15492250
ENSG00000125482 TTF1 tumors 15595193
ENSG00000125482 TTF1 tumor 20513429
ENSG00000125482 TTF1 tumour 22383580
ENSG00000125482 TTF1 Colorectal Cancer 26036188
ENSG00000125482 TTF1 Tumor 31543703
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000125482 TTF1 STAD 0.0096 low
ENSG00000125482 TTF1 CHOL 0.045 low
ENSG00000125482 TTF1 ACC 0.00054 high
ENSG00000125482 TTF1 LUSC 0.036 high
ENSG00000125482 TTF1 PCPG 0.05 high
ENSG00000125482 TTF1 THYM 0.0021 low
ENSG00000125482 TTF1 COAD 0.012 high
ENSG00000125482 TTF1 UCS 0.023 high
ENSG00000125482 TTF1 PRAD 0.0077 high
ENSG00000125482 TTF1 BLCA 0.0074 low
ENSG00000125482 TTF1 SKCM 0.012 low
ENSG00000125482 TTF1 CESC 0.0074 low
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000125482 TTF1 SARC Del 1.326432 0.139860 0.512027 0.229572
ENSG00000125482 TTF1 UCEC Del 1.801343 0.061263 0.540171 0.241187
ENSG00000125482 TTF1 OV Del 4.937414 0.245887 0.572349 0.587219