Ensembl ID ENSG00000125354 Gene ID 23157 Accession 15848
Gene Symbol SEPTIN6 Alias SEP2;SEPT2;SEPT6 Full Name septin 6
Position X : 119615724 - 119693370 Length 77647 bases Strand Minus strand
Status Confidence Main interacting RNAsN.A.RBP type Canonical_RBPs
Summary This gene is a member of the septin family of GTPases. Members of this family are required for cytokinesis. One version of pediatric acute myeloid leukemia is the result of a reciprocal translocation between chromosomes 11 and X, with the breakpoint associated with the genes encoding the mixed-lineage leukemia and septin 2 proteins. This gene encodes four transcript variants encoding three distinct isoforms. An additional transcript variant has been identified, but its biological validity has not been determined. [provided by RefSeq, Jul 2008]

ENSG00000125354 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000125354 -0.5 5.64e-14 KIRC
ENSG00000125354 -1.1 4.23e-21 COAD
ENSG00000125354 -1.5 3.06e-12 READ
ENSG00000125354 -1.1 6.14e-17 KIRP
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000125354 AML-M2 11477664
ENSG00000125354 ovarian tumor 12095151
ENSG00000125354 acute myeloid leukemia (AML) 14506700
ENSG00000125354 tumor 16314519
ENSG00000125354 AML-M4 16843108
ENSG00000125354 tumour 20642484
ENSG00000125354 prostate cancer 25519054
ENSG00000125354 cancers 25969993
ENSG00000125354 tumor 27882315
ENSG00000125354 cancer 30029628
ENSG00000125354 AML 31723831
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
ENSG00000125354 clear cell renal carcinoma sequence_alteration 0.13% (2/1539) 1 entry
ENSG00000125354 colon adenocarcinoma sequence_alteration 0.831% (6/722) 1 entry
ENSG00000125354 hairy cell leukemia missense_variant 9.524% (2/21) 1 entry
ENSG00000125354 colon adenocarcinoma missense_variant 0.831% (6/722) 2 entries
ENSG00000125354 melanoma missense_variant 1.98% (2/101) 2 entries
ENSG00000125354 chronic lymphocytic leukemia missense_variant 1.126% (10/888) 1 entry
ENSG00000125354 acute myeloid leukemia gene_fusion 1.314% (12/913) 4 entries
ENSG00000125354 cecum adenocarcinoma missense_variant 2.4% (3/125) 1 entry
ENSG00000125354 colorectal adenocarcinoma missense_variant 2.548% (29/1138) 2 entries
ENSG00000125354 hepatocellular carcinoma missense_variant 1.111% (10/900) 1 entry
ENSG00000125354 prostate carcinoma missense_variant 0.4132% (2/484) 2 entries
ENSG00000125354 small cell lung carcinoma missense_variant 1.235% (4/324) 2 entries
ENSG00000125354 brain glioblastoma sequence_alteration 0.324% (3/926) 1 entry
ENSG00000125354 colorectal adenocarcinoma frameshift_variant 2.548% (29/1138) 1 entry
ENSG00000125354 colorectal adenocarcinoma sequence_alteration 2.548% (29/1138) 3 entries
ENSG00000125354 skin melanoma missense_variant 0.6205% (6/967) 1 entry
ENSG00000125354 lung adenocarcinoma missense_variant 0.7377% (9/1220) 3 entries
ENSG00000125354 ovarian neoplasm missense_variant 1.724% (1/58) 1 entry
ENSG00000125354 small cell lung carcinoma sequence_alteration 1.235% (4/324) 1 entry
ENSG00000125354 oral squamous cell carcinoma frameshift_variant 0.4854% (1/206) 1 entry
ENSG00000125354 diffuse gastric adenocarcinoma missense_variant 1.266% (1/79) 1 entry
ENSG00000125354 brain glioma missense_variant 11.11% (1/9) 1 entry
ENSG00000125354 Thyroid Gland Oncocytic Follicular Carcinoma missense_variant 50.0% (1/2) 1 entry
ENSG00000125354 Ampulla of Vater Carcinoma missense_variant 1.176% (1/85) 1 entry
ENSG00000125354 Brain Stem Glioblastoma sequence_alteration 1.786% (1/56) 1 entry
ENSG00000125354 Cortisol-Producing Adrenal Cortex Adenoma missense_variant 0.8065% (1/124) 1 entry
ENSG00000125354 esophageal squamous cell carcinoma stop_gained 0.2963% (2/675) 1 entry
ENSG00000125354 pseudomyxoma peritonei missense_variant 10.0% (1/10) 1 entry
ENSG00000125354 small intestinal adenocarcinoma frameshift_variant 100.0% (1/1) 1 entry
ENSG00000125354 basal cell carcinoma missense_variant 1.724% (1/58) 1 entry
ENSG00000125354 ependymoma sequence_alteration 2.174% (1/46) 1 entry
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000125354 MESO 0.00033 high
ENSG00000125354 UVM 0.00013 high
ENSG00000125354 ACC 0.02 high
ENSG00000125354 READ 0.032 high
ENSG00000125354 LUAD 0.0093 low
ENSG00000125354 THYM 0.0022 low
ENSG00000125354 BRCA 0.014 low
ENSG00000125354 OV 0.022 low
ENSG00000125354 KIRC 0.017 high
ENSG00000125354 BLCA 0.041 high
ENSG00000125354 LAML 0.035 low
ENSG00000125354 GBM 0.036 high
ENSG00000125354 SKCM 9e-04 low
ENSG00000125354 CESC 0.002 low
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency