Ensembl ID ENSG00000125351 Gene ID 65109 Accession 20439
Gene Symbol UPF3B Alias MRX62;MRX82;UPF3X;HUPF3B;MRXS14;RENT3B;UPF3BP1;UPF3BP2;UPF3BP3;Upf3p-X Full Name UPF3B regulator of nonsense mediated mRNA decay
Position X : 119834022 - 119852998 Length 18977 bases Strand Minus strand
Status Confidence Main interacting RNAsmRNARBP type Canonical_RBPs
Summary This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. The encoded protein is one of two functional homologs to yeast Upf3p. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein binds to the mRNA and remains bound after nuclear export, acting as a nucleocytoplasmic shuttling protein. It forms with Y14 a complex that binds specifically 20 nt upstream of exon-exon junctions. This gene is located on the long arm of chromosome X. Two splice variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

ENSG00000125351 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000125351 UPF3B 0.84 2.39e-18 COAD
ENSG00000125351 UPF3B 1.15 8.35e-36 LUSC
ENSG00000125351 UPF3B 0.86 9.16e-22 LIHC
ENSG00000125351 UPF3B 0.59 4.59e-14 LUAD
Ensembl ID Gene symbol Cancer types Pubmed ID
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000125351 UPF3B STAD 0.022 low
ENSG00000125351 UPF3B CHOL 0.015 high
ENSG00000125351 UPF3B PAAD 0.049 low
ENSG00000125351 UPF3B UCEC 0.0032 high
ENSG00000125351 UPF3B LGG 0.0012 high
ENSG00000125351 UPF3B LUSC 0.001 low
ENSG00000125351 UPF3B HNSC 0.028 high
ENSG00000125351 UPF3B KIRP 0.00067 high
ENSG00000125351 UPF3B KICH 0.024 high
ENSG00000125351 UPF3B THYM 0.049 high
ENSG00000125351 UPF3B COAD 0.0067 high
ENSG00000125351 UPF3B UCS 0.00014 low
ENSG00000125351 UPF3B ESCA 0.00075 high
ENSG00000125351 UPF3B PRAD 0.00033 high
ENSG00000125351 UPF3B BLCA 0.0063 low
ENSG00000125351 UPF3B SKCM 0.0043 low
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency