Ensembl ID ENSG00000124570 Gene ID 5269 Accession 8950
Gene Symbol SERPINB6 Alias CAP;PI6;PTI;PI-6;SPI3;DFNB91;MSTP057 Full Name serpin family B member 6
Position 6 : 2948159 - 2972165 Length 24007 bases Strand Minus strand
Status Confidence Main interacting RNAsN.A.RBP type Non-canonical_RBPs
Summary The protein encoded by this gene is a member of the serpin (serine proteinase inhibitor) superfamily, and ovalbumin(ov)-serpin subfamily. It was originally discovered as a placental thrombin inhibitor. The mouse homolog was found to be expressed in the hair cells of the inner ear. Mutations in this gene are associated with nonsyndromic progressive hearing loss, suggesting that this serpin plays an important role in the inner ear in the protection against leakage of lysosomal content during stress, and that loss of this protection results in cell death and sensorineural hearing loss. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2010]

ENSG00000124570 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000124570 0.53 4.20e-24 KIRC
ENSG00000124570 -1.2 1.21e-28 LUSC
ENSG00000124570 -0.5 1.23e-12 LUAD
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000124570 cancer 10216950
ENSG00000124570 prostate cancer 10463585
ENSG00000124570 pancreatic cancer 10554036
ENSG00000124570 tumour 10674022
ENSG00000124570 prostate cancer 11745444
ENSG00000124570 prostate tumor 12736433
ENSG00000124570 cancer 14652284
ENSG00000124570 prostate tumor 15716006
ENSG00000124570 colon cancer 16684083
ENSG00000124570 prostate cancer 16707856
ENSG00000124570 cancer 16717037
ENSG00000124570 cancer 16969121
ENSG00000124570 prostate tumor 18853312
ENSG00000124570 colon cancer 19425502
ENSG00000124570 squamous cell cancer 1997617
ENSG00000124570 tumour 20838377
ENSG00000124570 prostate cancer 22355332
ENSG00000124570 lung cancer 23338686
ENSG00000124570 cancer 24195657
ENSG00000124570 pancreatic cancer 24405276
ENSG00000124570 tumors 24571548
ENSG00000124570 cancer 25621294
ENSG00000124570 prostate cancer 26110379
ENSG00000124570 cancer 26337905
ENSG00000124570 Pancreatic cancer 27429841
ENSG00000124570 cancer 28874822
ENSG00000124570 tumor 29137411
ENSG00000124570 tumor 29517999
ENSG00000124570 cervical cancer 31271297
ENSG00000124570 tumor 31602163
ENSG00000124570 cancer 31976125
ENSG00000124570 tumor 7542776
ENSG00000124570 tumor 8988032
ENSG00000124570 cancer 9465091
ENSG00000124570 colon cancer 9713282
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000124570 MESO 0.025 high
ENSG00000124570 UVM 0.00027 low
ENSG00000124570 UCEC 0.0016 low
ENSG00000124570 ACC 0.012 high
ENSG00000124570 LUSC 0.044 high
ENSG00000124570 HNSC 0.012 high
ENSG00000124570 READ 0.0038 low
ENSG00000124570 KICH 0.011 high
ENSG00000124570 LUAD 0.0072 low
ENSG00000124570 PCPG 0.007 low
ENSG00000124570 COAD 0.026 high
ENSG00000124570 UCS 0.0011 high
ENSG00000124570 OV 0.00019 low
ENSG00000124570 TGCT 0.017 high
ENSG00000124570 BLCA 0.0021 low
ENSG00000124570 LAML 0.00032 high
ENSG00000124570 GBM 0.022 high
ENSG00000124570 LIHC 0.0021 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000124570 LUSC Del 2.404490 0.087736 0.360538 0.261477
ENSG00000124570 THYM Del 2.873248 0.080979 0.405209 0.211382
ENSG00000124570 SARC Del 1.218740 0.136911 0.515255 0.319066
ENSG00000124570 PAAD Del 2.624918 0.080610 0.355778 0.402174
ENSG00000124570 ESCA Del 7.106273 0.235359 0.447055 0.353261
ENSG00000124570 SKCM Amp 5.836903 0.262728 0.752125 0.572207
ENSG00000124570 HNSC Del 0.664668 0.053510 0.361886 0.178161
ENSG00000124570 LIHC Amp 4.660479 0.200652 0.760905 0.429730
ENSG00000124570 BLCA Amp 1.257285 0.185074 0.448673 0.289216
ENSG00000124570 BLCA Del 2.373866 0.103489 0.392569 0.220588
ENSG00000124570 BRCA Del 3.975190 0.087113 0.428485 0.182407
ENSG00000124570 STAD Del 4.555516 0.104583 0.395599 0.185941
ENSG00000124570 UVM Amp 3.966451 0.349455 1.179661 0.562500
ENSG00000124570 OV Amp 5.591620 0.463439 0.737896 0.480138