Ensembl ID ENSG00000124207 Gene ID 1434 Accession 2431
Gene Symbol CSE1L Alias CAS;CSE1;XPO2 Full Name chromosome segregation 1 like
Position 20 : 49046246 - 49096960 Length 50715 bases Strand Plus strand
Status Confidence Main interacting RNAsN.A.RBP type Canonical_RBPs
Summary Proteins that carry a nuclear localization signal (NLS) are transported into the nucleus by the importin-alpha/beta heterodimer. Importin-alpha binds the NLS, while importin-beta mediates translocation through the nuclear pore complex. After translocation, RanGTP binds importin-beta and displaces importin-alpha. Importin-alpha must then be returned to the cytoplasm, leaving the NLS protein behind. The protein encoded by this gene binds strongly to NLS-free importin-alpha, and this binding is released in the cytoplasm by the combined action of RANBP1 and RANGAP1. In addition, the encoded protein may play a role both in apoptosis and in cell proliferation. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012]

ENSG00000124207 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000124207 0.84 1.03e-36 BRCA
ENSG00000124207 1.55 5.91e-63 COAD
ENSG00000124207 1.51 6.95e-16 READ
ENSG00000124207 1.49 2.26e-83 LUSC
ENSG00000124207 0.60 1.20e-15 LIHC
ENSG00000124207 1.08 3.76e-19 STAD
ENSG00000124207 0.77 2.47e-13 UCEC
ENSG00000124207 0.70 7.87e-16 LUAD
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000124207 tumor 11295109
ENSG00000124207 breast cancer 11724300
ENSG00000124207 tumor 12460888
ENSG00000124207 tumour 17934491
ENSG00000124207 cancer 18059182
ENSG00000124207 cancer 18377724
ENSG00000124207 cancer 18597698
ENSG00000124207 metastatic cancer 19383891
ENSG00000124207 cancer 20122194
ENSG00000124207 metastatic colorectal cancer 20150437
ENSG00000124207 breast cancer 20688056
ENSG00000124207 cancer 20701792
ENSG00000124207 ovarian cancer 22389439
ENSG00000124207 colorectal cancer 22450763
ENSG00000124207 tumors 22476051
ENSG00000124207 bladder cancer 22653741
ENSG00000124207 colorectal cancer 22711543
ENSG00000124207 tumor 22952058
ENSG00000124207 oligodendroglial tumors 23252729
ENSG00000124207 colorectal cancer 23369209
ENSG00000124207 colon cancer 23621178
ENSG00000124207 cancer 23771064
ENSG00000124207 colorectal cancer 23806821
ENSG00000124207 ovarian cancer 23948303
ENSG00000124207 breast cancer 25791533
ENSG00000124207 cancer 25973023
ENSG00000124207 colorectal tumor 26070816
ENSG00000124207 Breast Cancer 26278417
ENSG00000124207 tumor 27307036
ENSG00000124207 Colorectal Cancer 27521996
ENSG00000124207 cancer 27596143
ENSG00000124207 breast cancer 27642640
ENSG00000124207 cancers 27941559
ENSG00000124207 ovarian cancer 28387323
ENSG00000124207 breast cancer 28472320
ENSG00000124207 tumors 28790116
ENSG00000124207 tumor 30144787
ENSG00000124207 tumours 30485574
ENSG00000124207 endometrial cancer 31134156
ENSG00000124207 cancers 31139015
ENSG00000124207 gastric cancer 31347172
ENSG00000124207 cancer 31371628
ENSG00000124207 larynx tumors 31383592
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000124207 SARC 0.0014 high
ENSG00000124207 PAAD 0.0025 high
ENSG00000124207 LUSC 0.049 low
ENSG00000124207 KICH 0.00012 high
ENSG00000124207 LUAD 0.00085 high
ENSG00000124207 PCPG 0.02 high
ENSG00000124207 ESCA 0.018 high
ENSG00000124207 OV 0.047 low
ENSG00000124207 DLBC 0.0059 low
ENSG00000124207 PRAD 0.0027 high
ENSG00000124207 BLCA 0.00069 high
ENSG00000124207 CESC 0.024 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000124207 READ Amp 2.155434 0.196430 1.330067 0.890909
ENSG00000124207 COAD Amp 4.721134 0.136591 1.190691 0.725055
ENSG00000124207 BRCA Amp 5.769173 0.220943 0.644421 0.467593
ENSG00000124207 STAD Amp 2.820204 0.189970 0.708202 0.659864
ENSG00000124207 PRAD Amp 0.656974 0.044530 0.405558 0.075203