Ensembl ID ENSG00000123983 Gene ID 2181 Accession 3570
Gene Symbol ACSL3 Alias ACS3;FACL3;LACS3;LACS3;PRO2194 Full Name acyl-CoA synthetase long chain family member 3
Position 2 : 222860942 - 222944639 Length 83698 bases Strand Plus strand
Status Confidence Main interacting RNAsN.A.RBP type Non-canonical_RBPs
Summary The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme is highly expressed in brain, and preferentially utilizes myristate, arachidonate, and eicosapentaenoate as substrates. The amino acid sequence of this isozyme is 92% identical to that of rat homolog. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

ENSG00000123983 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000123983 ACSL3 -0.9 3.65e-43 KIRC
ENSG00000123983 ACSL3 -0.7 1.73e-12 KIRP
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000123983 ACSL3 prostate cancer 15178414
ENSG00000123983 ACSL3 prostate cancer 15556626
ENSG00000123983 ACSL3 prostate cancer 18594527
ENSG00000123983 ACSL3 prostate cancer 21041072
ENSG00000123983 ACSL3 prostate tumors 21829708
ENSG00000123983 ACSL3 breast cancer 26083392
ENSG00000123983 ACSL3 cancer 27171439
ENSG00000123983 ACSL3 prostate cancer 27270436
ENSG00000123983 ACSL3 lung cancer 27477280
ENSG00000123983 ACSL3 basal-like breast cancers 28412757
ENSG00000123983 ACSL3 prostate cancer 28771887
ENSG00000123983 ACSL3 breast cancer 29450800
ENSG00000123983 ACSL3 cancer 30008815
ENSG00000123983 ACSL3 cancer 30028354
ENSG00000123983 ACSL3 cancer 31344914
ENSG00000123983 ACSL3 prostate cancer 31454442
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
ENSG00000123983 ACSL3 prostate adenocarcinoma gene_fusion 4.533% (68/1500) 1 entry
ENSG00000123983 ACSL3 lung adenocarcinoma missense_variant 0.7739% (9/1163) 3 entries
ENSG00000123983 ACSL3 brain glioblastoma sequence_alteration 0.7559% (7/926) 1 entry
ENSG00000123983 ACSL3 ovarian serous adenocarcinoma missense_variant 0.2972% (2/673) 1 entry
ENSG00000123983 ACSL3 basal cell carcinoma missense_variant 5.172% (3/58) 1 entry
ENSG00000123983 ACSL3 prostate carcinoma sequence_alteration 3.286% (14/426) 1 entry
ENSG00000123983 ACSL3 skin melanoma missense_variant 1.758% (17/967) 4 entries
ENSG00000123983 ACSL3 pancreatic ductal adenocarcinoma missense_variant 3.177% (40/1259) 1 entry
ENSG00000123983 ACSL3 colon adenocarcinoma missense_variant 2.216% (16/722) 4 entries
ENSG00000123983 ACSL3 prostate adenocarcinoma sequence_alteration 4.533% (68/1500) 1 entry
ENSG00000123983 ACSL3 breast ductal adenocarcinoma sequence_alteration 4.966% (29/584) 1 entry
ENSG00000123983 ACSL3 colon adenocarcinoma sequence_alteration 2.216% (16/722) 2 entries
ENSG00000123983 ACSL3 female breast carcinoma missense_variant 1.124% (3/267) 1 entry
ENSG00000123983 ACSL3 HER2 Positive Breast Carcinoma missense_variant 11.11% (12/108) 1 entry
ENSG00000123983 ACSL3 prostate carcinoma missense_variant 3.286% (14/426) 3 entries
ENSG00000123983 ACSL3 lung adenocarcinoma stop_gained 0.7739% (9/1163) 1 entry
ENSG00000123983 ACSL3 colorectal adenocarcinoma sequence_alteration 3.779% (43/1138) 1 entry
ENSG00000123983 ACSL3 colorectal adenocarcinoma missense_variant 3.779% (43/1138) 1 entry
ENSG00000123983 ACSL3 laryngeal squamous cell carcinoma stop_gained 7.692% (2/26) 1 entry
ENSG00000123983 ACSL3 esophageal squamous cell carcinoma sequence_alteration 0.4444% (3/675) 2 entries
ENSG00000123983 ACSL3 breast carcinoma missense_variant 0.4961% (7/1411) 1 entry
ENSG00000123983 ACSL3 nodular melanoma missense_variant 50.0% (1/2) 1 entry
ENSG00000123983 ACSL3 anaplastic astrocytoma sequence_alteration 2.222% (1/45) 1 entry
ENSG00000123983 ACSL3 Pleural Sarcomatoid Mesothelioma stop_gained 16.67% (1/6) 1 entry
ENSG00000123983 ACSL3 adenosquamous lung carcinoma missense_variant 9.091% (1/11) 1 entry
ENSG00000123983 ACSL3 Endometrial Endometrioid Adenocarcinoma sequence_alteration 1.27% (7/551) 1 entry
ENSG00000123983 ACSL3 melanoma stop_gained 1.98% (2/101) 1 entry
ENSG00000123983 ACSL3 melanoma missense_variant 1.98% (2/101) 1 entry
ENSG00000123983 ACSL3 basal cell carcinoma sequence_alteration 5.172% (3/58) 1 entry
ENSG00000123983 ACSL3 clear cell renal carcinoma sequence_alteration 0.5806% (8/1378) 1 entry
ENSG00000123983 ACSL3 cecum adenocarcinoma missense_variant 0.8% (1/125) 1 entry
ENSG00000123983 ACSL3 skin melanoma frameshift_variant 1.758% (17/967) 1 entry
ENSG00000123983 ACSL3 colorectal adenocarcinoma stop_gained 3.779% (43/1138) 1 entry
ENSG00000123983 ACSL3 Sarcomatoid Mesothelioma missense_variant 100.0% (1/1) 1 entry
ENSG00000123983 ACSL3 Parathyroid Gland Carcinoma missense_variant 5.263% (1/19) 1 entry
ENSG00000123983 ACSL3 female breast carcinoma frameshift_variant 1.124% (3/267) 1 entry
ENSG00000123983 ACSL3 gastric intestinal type adenocarcinoma missense_variant 1.176% (1/85) 1 entry
ENSG00000123983 ACSL3 esophageal squamous cell carcinoma missense_variant 0.4444% (3/675) 1 entry
ENSG00000123983 ACSL3 gastric adenocarcinoma frameshift_variant 1.254% (7/558) 1 entry
ENSG00000123983 ACSL3 hemangioblastoma sequence_alteration 3.125% (1/32) 1 entry
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000123983 ACSL3 MESO 0.016 high
ENSG00000123983 ACSL3 UVM 0.0014 high
ENSG00000123983 ACSL3 UCEC 0.0055 low
ENSG00000123983 ACSL3 ACC 0.041 high
ENSG00000123983 ACSL3 HNSC 0.025 high
ENSG00000123983 ACSL3 KIRP 0.0049 high
ENSG00000123983 ACSL3 LUAD 0.00056 high
ENSG00000123983 ACSL3 PCPG 0.0015 low
ENSG00000123983 ACSL3 THYM 0.0028 low
ENSG00000123983 ACSL3 COAD 0.044 low
ENSG00000123983 ACSL3 KIRC 0.00027 low
ENSG00000123983 ACSL3 PRAD 0.027 high
ENSG00000123983 ACSL3 LAML 0.0058 high
ENSG00000123983 ACSL3 SKCM 0.0051 low
ENSG00000123983 ACSL3 LIHC 0.00087 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000123983 ACSL3 LUSC Del 15.984636 0.186709 0.388776 0.299401
ENSG00000123983 ACSL3 CESC Del 34.151855 0.347549 0.526276 0.410169
ENSG00000123983 ACSL3 KIRP Amp 1.259300 0.069152 0.554374 0.163194
ENSG00000123983 ACSL3 KIRP Del 2.448110 0.043607 0.632629 0.041667
ENSG00000123983 ACSL3 SARC Del 4.072301 0.200522 0.515747 0.342412
ENSG00000123983 ACSL3 ESCA Del 2.007677 0.133566 0.374437 0.233696
ENSG00000123983 ACSL3 SKCM Del 0.821440 0.068440 0.398504 0.177112
ENSG00000123983 ACSL3 HNSC Del 22.861477 0.186664 0.393144 0.291188
ENSG00000123983 ACSL3 BLCA Del 24.906093 0.279950 0.439606 0.477941
ENSG00000123983 ACSL3 BRCA Del 1.417280 0.069971 0.348485 0.260185
ENSG00000123983 ACSL3 UCEC Del 0.676114 0.047203 0.441416 0.079777
ENSG00000123983 ACSL3 KIRC Del 9.932998 0.066435 0.538731 0.087121
ENSG00000123983 ACSL3 OV Del 1.336806 0.189417 0.489774 0.250432