Ensembl ID ENSG00000123983 Gene ID 2181 Accession 3570
Gene Symbol ACSL3 Alias ACS3;FACL3;LACS3;LACS3;PRO2194 Full Name acyl-CoA synthetase long chain family member 3
Position 2 : 222860942 - 222944639 Length 83698 bases Strand Plus strand
Status Confidence Main interacting RNAsN.A.RBP type Non-canonical_RBPs
Summary The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme is highly expressed in brain, and preferentially utilizes myristate, arachidonate, and eicosapentaenoate as substrates. The amino acid sequence of this isozyme is 92% identical to that of rat homolog. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

ENSG00000123983 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000123983 -0.9 3.65e-43 KIRC
ENSG00000123983 -0.7 1.73e-12 KIRP
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000123983 prostate cancer 15178414
ENSG00000123983 prostate cancer 15556626
ENSG00000123983 prostate cancer 18594527
ENSG00000123983 prostate cancer 21041072
ENSG00000123983 prostate tumors 21829708
ENSG00000123983 breast cancer 26083392
ENSG00000123983 cancer 27171439
ENSG00000123983 prostate cancer 27270436
ENSG00000123983 lung cancer 27477280
ENSG00000123983 basal-like breast cancers 28412757
ENSG00000123983 prostate cancer 28771887
ENSG00000123983 breast cancer 29450800
ENSG00000123983 cancer 30008815
ENSG00000123983 cancer 30028354
ENSG00000123983 cancer 31344914
ENSG00000123983 prostate cancer 31454442
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
ENSG00000123983 prostate adenocarcinoma gene_fusion 4.533% (68/1500) 1 entry
ENSG00000123983 lung adenocarcinoma missense_variant 0.7739% (9/1163) 3 entries
ENSG00000123983 brain glioblastoma sequence_alteration 0.7559% (7/926) 1 entry
ENSG00000123983 ovarian serous adenocarcinoma missense_variant 0.2972% (2/673) 1 entry
ENSG00000123983 basal cell carcinoma missense_variant 5.172% (3/58) 1 entry
ENSG00000123983 prostate carcinoma sequence_alteration 3.286% (14/426) 1 entry
ENSG00000123983 skin melanoma missense_variant 1.758% (17/967) 4 entries
ENSG00000123983 pancreatic ductal adenocarcinoma missense_variant 3.177% (40/1259) 1 entry
ENSG00000123983 colon adenocarcinoma missense_variant 2.216% (16/722) 4 entries
ENSG00000123983 prostate adenocarcinoma sequence_alteration 4.533% (68/1500) 1 entry
ENSG00000123983 breast ductal adenocarcinoma sequence_alteration 4.966% (29/584) 1 entry
ENSG00000123983 colon adenocarcinoma sequence_alteration 2.216% (16/722) 2 entries
ENSG00000123983 female breast carcinoma missense_variant 1.124% (3/267) 1 entry
ENSG00000123983 HER2 Positive Breast Carcinoma missense_variant 11.11% (12/108) 1 entry
ENSG00000123983 prostate carcinoma missense_variant 3.286% (14/426) 3 entries
ENSG00000123983 lung adenocarcinoma stop_gained 0.7739% (9/1163) 1 entry
ENSG00000123983 colorectal adenocarcinoma sequence_alteration 3.779% (43/1138) 1 entry
ENSG00000123983 colorectal adenocarcinoma missense_variant 3.779% (43/1138) 1 entry
ENSG00000123983 laryngeal squamous cell carcinoma stop_gained 7.692% (2/26) 1 entry
ENSG00000123983 esophageal squamous cell carcinoma sequence_alteration 0.4444% (3/675) 2 entries
ENSG00000123983 breast carcinoma missense_variant 0.4961% (7/1411) 1 entry
ENSG00000123983 nodular melanoma missense_variant 50.0% (1/2) 1 entry
ENSG00000123983 anaplastic astrocytoma sequence_alteration 2.222% (1/45) 1 entry
ENSG00000123983 Pleural Sarcomatoid Mesothelioma stop_gained 16.67% (1/6) 1 entry
ENSG00000123983 adenosquamous lung carcinoma missense_variant 9.091% (1/11) 1 entry
ENSG00000123983 Endometrial Endometrioid Adenocarcinoma sequence_alteration 1.27% (7/551) 1 entry
ENSG00000123983 melanoma stop_gained 1.98% (2/101) 1 entry
ENSG00000123983 melanoma missense_variant 1.98% (2/101) 1 entry
ENSG00000123983 basal cell carcinoma sequence_alteration 5.172% (3/58) 1 entry
ENSG00000123983 clear cell renal carcinoma sequence_alteration 0.5806% (8/1378) 1 entry
ENSG00000123983 cecum adenocarcinoma missense_variant 0.8% (1/125) 1 entry
ENSG00000123983 skin melanoma frameshift_variant 1.758% (17/967) 1 entry
ENSG00000123983 colorectal adenocarcinoma stop_gained 3.779% (43/1138) 1 entry
ENSG00000123983 Sarcomatoid Mesothelioma missense_variant 100.0% (1/1) 1 entry
ENSG00000123983 Parathyroid Gland Carcinoma missense_variant 5.263% (1/19) 1 entry
ENSG00000123983 female breast carcinoma frameshift_variant 1.124% (3/267) 1 entry
ENSG00000123983 gastric intestinal type adenocarcinoma missense_variant 1.176% (1/85) 1 entry
ENSG00000123983 esophageal squamous cell carcinoma missense_variant 0.4444% (3/675) 1 entry
ENSG00000123983 gastric adenocarcinoma frameshift_variant 1.254% (7/558) 1 entry
ENSG00000123983 hemangioblastoma sequence_alteration 3.125% (1/32) 1 entry
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000123983 MESO 0.016 high
ENSG00000123983 UVM 0.0014 high
ENSG00000123983 UCEC 0.0055 low
ENSG00000123983 ACC 0.041 high
ENSG00000123983 HNSC 0.025 high
ENSG00000123983 KIRP 0.0049 high
ENSG00000123983 LUAD 0.00056 high
ENSG00000123983 PCPG 0.0015 low
ENSG00000123983 THYM 0.0028 low
ENSG00000123983 COAD 0.044 low
ENSG00000123983 KIRC 0.00027 low
ENSG00000123983 PRAD 0.027 high
ENSG00000123983 LAML 0.0058 high
ENSG00000123983 SKCM 0.0051 low
ENSG00000123983 LIHC 0.00087 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000123983 LUSC Del 15.984636 0.186709 0.388776 0.299401
ENSG00000123983 CESC Del 34.151855 0.347549 0.526276 0.410169
ENSG00000123983 KIRP Amp 1.259300 0.069152 0.554374 0.163194
ENSG00000123983 KIRP Del 2.448110 0.043607 0.632629 0.041667
ENSG00000123983 SARC Del 4.072301 0.200522 0.515747 0.342412
ENSG00000123983 ESCA Del 2.007677 0.133566 0.374437 0.233696
ENSG00000123983 SKCM Del 0.821440 0.068440 0.398504 0.177112
ENSG00000123983 HNSC Del 22.861477 0.186664 0.393144 0.291188
ENSG00000123983 BLCA Del 24.906093 0.279950 0.439606 0.477941
ENSG00000123983 BRCA Del 1.417280 0.069971 0.348485 0.260185
ENSG00000123983 UCEC Del 0.676114 0.047203 0.441416 0.079777
ENSG00000123983 KIRC Del 9.932998 0.066435 0.538731 0.087121
ENSG00000123983 OV Del 1.336806 0.189417 0.489774 0.250432