Ensembl ID ENSG00000122545 Gene ID 989 Accession 1717
Gene Symbol SEPTIN7 Alias CDC3;CDC10;SEPT7;SEPT7A;NBLA02942 Full Name septin 7
Position 7 : 35800932 - 35907110 Length 106179 bases Strand Plus strand
Status Confidence Main interacting RNAsN.A.RBP type Canonical_RBPs
Summary This gene encodes a protein that is highly similar to the CDC10 protein of Saccharomyces cerevisiae. The protein also shares similarity with Diff 6 of Drosophila and with H5 of mouse. Each of these similar proteins, including the yeast CDC10, contains a GTP-binding motif. The yeast CDC10 protein is a structural component of the 10 nm filament which lies inside the cytoplasmic membrane and is essential for cytokinesis. This human protein functions in gliomagenesis and in the suppression of glioma cell growth, and it is required for the association of centromere-associated protein E with the kinetochore. Alternative splicing results in multiple transcript variants. Several related pseudogenes have been identified on chromosomes 5, 7, 9, 10, 11, 14, 17 and 19. [provided by RefSeq, Jul 2011]

ENSG00000122545 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000122545 0.34 2.69e-12 KIRC
ENSG00000122545 -0.5 2.80e-21 PRAD
ENSG00000122545 -1.0 4.25e-25 UCEC
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000122545 AML 10485469
ENSG00000122545 tumors 20035367
ENSG00000122545 tumours 22284234
ENSG00000122545 tumor 23383034
ENSG00000122545 tumor 24604520
ENSG00000122545 tumor 26472042
ENSG00000122545 breast cancer 27557506
ENSG00000122545 breast cancer 27882315
ENSG00000122545 cancer 29602250
ENSG00000122545 tumor 29844869
ENSG00000122545 colorectal cancer 29956073
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000122545 MESO 0.0022 high
ENSG00000122545 STAD 0.012 high
ENSG00000122545 UVM 0.0086 high
ENSG00000122545 PAAD 0.044 high
ENSG00000122545 ACC 7e-04 high
ENSG00000122545 HNSC 0.025 high
ENSG00000122545 KIRP 0.032 high
ENSG00000122545 KICH 0.001 high
ENSG00000122545 THYM 0.0041 low
ENSG00000122545 BRCA 0.0053 high
ENSG00000122545 ESCA 0.014 high
ENSG00000122545 OV 0.038 low
ENSG00000122545 KIRC 0.013 low
ENSG00000122545 BLCA 0.0045 high
ENSG00000122545 LAML 0.0028 low
ENSG00000122545 CESC 0.0045 high
ENSG00000122545 LIHC 0.00037 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency