Ensembl ID ENSG00000122034 Gene ID 2971 Accession 4662
Gene Symbol GTF3A Alias AP2;TFIIIA Full Name general transcription factor IIIA
Position 13 : 27424619 - 27435823 Length 11205 bases Strand Plus strand
Status Confidence Main interacting RNAsrRNARBP type Canonical_RBPs
Summary The product of this gene is a zinc finger protein with nine Cis[2]-His[2] zinc finger domains. It functions as an RNA polymerase III transcription factor to induce transcription of the 5S rRNA genes. The protein binds to a 50 bp internal promoter in the 5S genes called the internal control region (ICR), and nucleates formation of a stable preinitiation complex. This complex recruits the TFIIIC and TFIIIB transcription factors and RNA polymerase III to form the complete transcription complex. The protein is thought to be translated using a non-AUG translation initiation site in mammals based on sequence analysis, protein homology, and the size of the purified protein. [provided by RefSeq, Jul 2008]

ENSG00000122034 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000122034 GTF3A 0.95 1.25e-32 KIRC
ENSG00000122034 GTF3A 0.42 4.51e-11 BRCA
ENSG00000122034 GTF3A 1.84 5.66e-40 COAD
ENSG00000122034 GTF3A 1.72 7.78e-11 READ
ENSG00000122034 GTF3A 1.01 2.75e-22 KIRP
ENSG00000122034 GTF3A 0.78 2.88e-13 UCEC
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000122034 GTF3A cancer 10190901
ENSG00000122034 GTF3A tumor 11814676
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000122034 GTF3A ACC 0.034 high
ENSG00000122034 GTF3A LGG 0.0014 high
ENSG00000122034 GTF3A READ 0.035 high
ENSG00000122034 GTF3A KICH 0.002 high
ENSG00000122034 GTF3A THYM 0.002 low
ENSG00000122034 GTF3A BRCA 0.0013 low
ENSG00000122034 GTF3A ESCA 0.037 high
ENSG00000122034 GTF3A KIRC 0.00012 high
ENSG00000122034 GTF3A PRAD 0.034 high
ENSG00000122034 GTF3A LAML 0.02 high
ENSG00000122034 GTF3A SKCM 0.00029 low
ENSG00000122034 GTF3A LIHC 0.017 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000122034 GTF3A LUSC Del 4.549572 0.108913 0.379609 0.676647
ENSG00000122034 GTF3A LUAD Del 5.377856 0.096096 0.333079 0.560078
ENSG00000122034 GTF3A LGG Del 2.719089 0.058459 0.451280 0.253411
ENSG00000122034 GTF3A CESC Del 5.406291 0.133221 0.477574 0.338983
ENSG00000122034 GTF3A READ Amp 11.874450 0.484829 1.151417 0.757576
ENSG00000122034 GTF3A COAD Amp 20.491554 0.320945 1.007174 0.600887
ENSG00000122034 GTF3A SARC Del 5.635900 0.227483 0.600902 0.517510
ENSG00000122034 GTF3A GBM Del 1.573856 0.062857 0.552308 0.341421
ENSG00000122034 GTF3A THCA Del 1.092866 0.011065 0.578274 0.032064
ENSG00000122034 GTF3A HNSC Del 11.661860 0.130457 0.394092 0.423372
ENSG00000122034 GTF3A LIHC Del 4.847123 0.119969 0.566440 0.372973
ENSG00000122034 GTF3A MESO Del 1.992141 0.176708 0.484558 0.494253
ENSG00000122034 GTF3A OV Del 0.853544 0.178011 0.608851 0.580311