Ensembl ID ENSG00000121390 Gene ID 55269 Accession 20320
Gene Symbol PSPC1 Alias PSP1 Full Name paraspeckle component 1
Position 13 : 19674756 - 19783019 Length 108264 bases Strand Minus strand
Status Confidence Main interacting RNAsncRNARBP type Canonical_RBPs
Summary This gene encodes a nucleolar protein that localizes to punctate subnuclear structures that occur close to splicing speckles, known as paraspeckles. These paraspeckles are composed of RNA-protein structures that include a non-coding RNA, NEAT1/Men epsilon/beta, and the Drosophila Behavior Human Splicing family of proteins, which include the product of this gene and the P54NRB/NONO and PSF/SFPQ proteins. Paraspeckles may function in the control of gene expression via an RNA nuclear retention mechanism. The protein encoded by this gene is found in paraspeckles in transcriptionally active cells, but it localizes to unique cap structures at the nucleolar periphery when RNA polymerase II transcription is inhibited, or during telophase. Alternative splicing of this gene results in multiple transcript variants. A related pseudogene, which is also located on chromosome 13, has been identified. [provided by RefSeq, Aug 2011]

ENSG00000121390 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000121390 PSPC1 -0.3 5.76e-20 KIRC
ENSG00000121390 PSPC1 0.35 3.48e-16 BRCA
ENSG00000121390 PSPC1 0.52 2.93e-15 COAD
ENSG00000121390 PSPC1 -0.6 5.84e-13 KICH
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000121390 PSPC1 tumor 25803297
ENSG00000121390 PSPC1 breast cancer 28673861
ENSG00000121390 PSPC1 cancer 29593326
ENSG00000121390 PSPC1 Colorectal Cancer 29982102
ENSG00000121390 PSPC1 cancer 30250921
ENSG00000121390 PSPC1 cancer 30377567
ENSG00000121390 PSPC1 tumour 30946555
ENSG00000121390 PSPC1 tumor 31300476
ENSG00000121390 PSPC1 tumor 31844057
ENSG00000121390 PSPC1 renal tumor 9609467
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000121390 PSPC1 MESO 0.035 low
ENSG00000121390 PSPC1 STAD 0.0045 low
ENSG00000121390 PSPC1 CHOL 0.029 low
ENSG00000121390 PSPC1 UVM 0.0073 high
ENSG00000121390 PSPC1 PAAD 0.0013 low
ENSG00000121390 PSPC1 ACC 0.00045 high
ENSG00000121390 PSPC1 LUSC 0.00061 low
ENSG00000121390 PSPC1 HNSC 0.0047 low
ENSG00000121390 PSPC1 LUAD 0.027 high
ENSG00000121390 PSPC1 PCPG 0.028 high
ENSG00000121390 PSPC1 THYM 0.02 low
ENSG00000121390 PSPC1 BRCA 0.0027 low
ENSG00000121390 PSPC1 UCS 0.023 low
ENSG00000121390 PSPC1 OV 0.044 high
ENSG00000121390 PSPC1 KIRC 0.0057 low
ENSG00000121390 PSPC1 LAML 0.014 low
ENSG00000121390 PSPC1 GBM 0.0062 low
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000121390 PSPC1 LUSC Del 8.714962 0.141544 0.388134 0.666667
ENSG00000121390 PSPC1 LUAD Del 14.052233 0.150648 0.354465 0.565891
ENSG00000121390 PSPC1 LGG Del 3.039343 0.060991 0.448005 0.241715
ENSG00000121390 PSPC1 CESC Del 8.313668 0.161113 0.484666 0.338983
ENSG00000121390 PSPC1 READ Amp 5.988803 0.331047 1.063211 0.703030
ENSG00000121390 PSPC1 SARC Del 3.539525 0.189990 0.578574 0.447471
ENSG00000121390 PSPC1 GBM Del 2.573703 0.072802 0.549934 0.320624
ENSG00000121390 PSPC1 ESCA Del 2.015612 0.133566 0.396957 0.407609
ENSG00000121390 PSPC1 HNSC Del 21.603443 0.179612 0.412021 0.434866
ENSG00000121390 PSPC1 LIHC Del 4.069855 0.111191 0.546472 0.343243
ENSG00000121390 PSPC1 BLCA Del 1.305010 0.087567 0.372856 0.213235
ENSG00000121390 PSPC1 BRCA Del 4.544610 0.090221 0.460511 0.397222
ENSG00000121390 PSPC1 STAD Del 1.071149 0.066039 0.343237 0.136054
ENSG00000121390 PSPC1 PRAD Amp 1.016776 0.050530 0.483864 0.050813
ENSG00000121390 PSPC1 UCEC Del 2.334379 0.066486 0.519422 0.179963
ENSG00000121390 PSPC1 MESO Del 1.872635 0.171731 0.471879 0.436782
ENSG00000121390 PSPC1 OV Del 3.892634 0.232237 0.610698 0.571675