Ensembl ID ENSG00000120948 Gene ID 23435 Accession 11571
Gene Symbol TARDBP Alias ALS10;TDP-43 Full Name TAR DNA binding protein
Position 1 : 11012344 - 11030528 Length 18185 bases Strand Plus strand
Status Confidence Main interacting RNAsmRNARBP type Canonical_RBPs
Summary HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. The protein encoded by this gene is a transcriptional repressor that binds to chromosomally integrated TAR DNA and represses HIV-1 transcription. In addition, this protein regulates alternate splicing of the CFTR gene. A similar pseudogene is present on chromosome 20. [provided by RefSeq, Jul 2008]

ENSG00000120948 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000120948 TARDBP 0.23 6.48e-18 BRCA
ENSG00000120948 TARDBP 0.33 4.21e-13 LUSC
ENSG00000120948 TARDBP 0.43 6.30e-11 STAD
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000120948 TARDBP tumors 18087705
ENSG00000120948 TARDBP cancer 22277495
ENSG00000120948 TARDBP cancer 23339301
ENSG00000120948 TARDBP cancer 23443080
ENSG00000120948 TARDBP tumours 23900711
ENSG00000120948 TARDBP cancer 24870760
ENSG00000120948 TARDBP tumours 26261209
ENSG00000120948 TARDBP non-small cell lung cancer 26265046
ENSG00000120948 TARDBP tumor 26516189
ENSG00000120948 TARDBP cancer 26571498
ENSG00000120948 TARDBP breast cancer 26902425
ENSG00000120948 TARDBP cancers 27786596
ENSG00000120948 TARDBP Cancer 27875990
ENSG00000120948 TARDBP AML 28831750
ENSG00000120948 TARDBP tumor 28915616
ENSG00000120948 TARDBP lung cancer 28952053
ENSG00000120948 TARDBP breast cancer 29421661
ENSG00000120948 TARDBP tumors 29499929
ENSG00000120948 TARDBP breast cancer 29581274
ENSG00000120948 TARDBP tumors 30087231
ENSG00000120948 TARDBP cancer 30394813
ENSG00000120948 TARDBP tumor 30872362
ENSG00000120948 TARDBP cancer 31047794
ENSG00000120948 TARDBP triple-negative breast cancer 31062657
ENSG00000120948 TARDBP non-small cell lung cancer 31081093
ENSG00000120948 TARDBP cancer 31262091
ENSG00000120948 TARDBP cancer 31863590
ENSG00000120948 TARDBP cancer 31928729
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000120948 TARDBP MESO 0.014 high
ENSG00000120948 TARDBP UCEC 0.02 high
ENSG00000120948 TARDBP LUSC 0.0077 low
ENSG00000120948 TARDBP HNSC 0.039 high
ENSG00000120948 TARDBP READ 0.027 low
ENSG00000120948 TARDBP KIRP 0.0051 high
ENSG00000120948 TARDBP THYM 0.00017 low
ENSG00000120948 TARDBP BRCA 0.0045 low
ENSG00000120948 TARDBP OV 0.012 low
ENSG00000120948 TARDBP DLBC 0.0049 low
ENSG00000120948 TARDBP PRAD 0.013 high
ENSG00000120948 TARDBP BLCA 0.011 low
ENSG00000120948 TARDBP SKCM 0.0027 low
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000120948 TARDBP CHOL Del 21.143569 1.070621 0.687456 0.805556
ENSG00000120948 TARDBP LUSC Del 5.041115 0.113451 0.385298 0.445110
ENSG00000120948 TARDBP LUAD Del 0.648186 0.050356 0.285647 0.220930
ENSG00000120948 TARDBP CESC Del 2.367918 0.096888 0.435885 0.128814
ENSG00000120948 TARDBP KIRP Del 6.772532 0.079319 0.590029 0.180556
ENSG00000120948 TARDBP ACC Del 3.728828 0.212921 0.595738 0.411111
ENSG00000120948 TARDBP READ Del 8.653354 0.212593 0.460154 0.442424
ENSG00000120948 TARDBP COAD Del 12.621543 0.127950 0.449053 0.323725
ENSG00000120948 TARDBP UCS Del 1.494121 0.270662 0.495129 0.321429
ENSG00000120948 TARDBP SARC Del 3.913031 0.197152 0.660684 0.206226
ENSG00000120948 TARDBP GBM Del 12.221160 0.138474 0.549938 0.133449
ENSG00000120948 TARDBP PAAD Del 1.540142 0.062370 0.343774 0.298913
ENSG00000120948 TARDBP SKCM Del 3.730652 0.108560 0.466812 0.201635
ENSG00000120948 TARDBP HNSC Del 3.714752 0.082754 0.389699 0.178161
ENSG00000120948 TARDBP LIHC Del 21.322062 0.245206 0.546641 0.400000
ENSG00000120948 TARDBP PCPG Del 2.000743 0.085543 0.671441 0.623457
ENSG00000120948 TARDBP TGCT Del 1.624698 0.078673 0.364808 0.213333
ENSG00000120948 TARDBP BRCA Del 35.048597 0.190366 0.431082 0.410185
ENSG00000120948 TARDBP STAD Amp 1.698992 0.161750 0.562487 0.145125
ENSG00000120948 TARDBP STAD Del 1.657818 0.074141 0.331346 0.208617
ENSG00000120948 TARDBP UCEC Amp 1.094985 0.113292 0.579412 0.109462
ENSG00000120948 TARDBP UCEC Del 6.026674 0.095611 0.498113 0.113173
ENSG00000120948 TARDBP MESO Del 4.524897 0.255107 0.529711 0.344828
ENSG00000120948 TARDBP KIRC Del 7.444739 0.057003 0.409524 0.191288
ENSG00000120948 TARDBP UVM Del 1.063142 0.074432 0.794743 0.300000
ENSG00000120948 TARDBP OV Del 15.160243 0.345176 0.550902 0.354059