Ensembl ID ENSG00000120705 Gene ID 2107 Accession 3477
Gene Symbol ETF1 Alias ERF;RF1;ERF1;TB3-1;D5S1995;SUP45L1 Full Name eukaryotic translation termination factor 1
Position 5 : 138506095 - 138543236 Length 37142 bases Strand Minus strand
Status Confidence Main interacting RNAsmRNARBP type Canonical_RBPs
Summary This gene encodes a class-1 polypeptide chain release factor. The encoded protein plays an essential role in directing termination of mRNA translation from the termination codons UAA, UAG and UGA. This protein is a component of the SURF complex which promotes degradation of prematurely terminated mRNAs via the mechanism of nonsense-mediated mRNA decay (NMD). Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 6, 7, and X. [provided by RefSeq, Aug 2013]

ENSG00000120705 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000120705 ETF1 -0.8 8.00e-12 BLCA
ENSG00000120705 ETF1 -0.4 4.39e-12 LUSC
ENSG00000120705 ETF1 -0.7 2.44e-36 LUAD
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000120705 ETF1 Cancer 10339451
ENSG00000120705 ETF1 myeloid tumor 11996793
ENSG00000120705 ETF1 breast cancer 15843208
ENSG00000120705 ETF1 prostate cancers 16423995
ENSG00000120705 ETF1 tumour 19284299
ENSG00000120705 ETF1 AML 25884877
ENSG00000120705 ETF1 tumor 27511050
ENSG00000120705 ETF1 tumour 31481105
ENSG00000120705 ETF1 giant cell tumor 3701159
ENSG00000120705 ETF1 tumor 4086924
ENSG00000120705 ETF1 cancers 6497397
ENSG00000120705 ETF1 gastric cancers 6513029
ENSG00000120705 ETF1 cancer 7750094
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000120705 ETF1 MESO 0.01 low
ENSG00000120705 ETF1 STAD 0.026 high
ENSG00000120705 ETF1 ACC 0.039 high
ENSG00000120705 ETF1 HNSC 0.015 high
ENSG00000120705 ETF1 READ 0.0038 low
ENSG00000120705 ETF1 KIRP 0.039 low
ENSG00000120705 ETF1 KICH 0.00026 high
ENSG00000120705 ETF1 LUAD 0.0043 high
ENSG00000120705 ETF1 THYM 0.0044 high
ENSG00000120705 ETF1 BRCA 0.032 high
ENSG00000120705 ETF1 COAD 0.00075 low
ENSG00000120705 ETF1 KIRC 0.00031 low
ENSG00000120705 ETF1 PRAD 0.043 high
ENSG00000120705 ETF1 SKCM 0.00054 low
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000120705 ETF1 LAML Del 6.887040 0.097495 0.800560 0.089005
ENSG00000120705 ETF1 LGG Del 0.883778 0.040942 0.386406 0.089669
ENSG00000120705 ETF1 SKCM Del 5.763381 0.130390 0.504202 0.329700
ENSG00000120705 ETF1 PCPG Del 0.608590 0.055469 0.664776 0.074074
ENSG00000120705 ETF1 KIRC Amp 49.876970 0.287482 0.540543 0.609848