Ensembl ID ENSG00000119203 Gene ID 51692 Accession 2326
Gene Symbol CPSF3 Alias CPSF73;NEDMHS;CPSF-73;NEDMHSN Full Name cleavage and polyadenylation specific factor 3
Position 2 : 9423651 - 9473101 Length 49451 bases Strand Plus strand
Status Confidence Main interacting RNAsmRNARBP type Canonical_RBPs
Summary This gene encodes a member of the metallo-beta-lactamase family. The encoded protein is a 73kDa subunit of the cleavage and polyadenylation specificity factor and functions as an endonuclease that recognizes the pre-mRNA 3'-cleavage site AAUAAA prior to polyadenylation. It also cleaves after the pre-mRNA sequence ACCCA during histone 3'-end pre-mRNA processing. [provided by RefSeq, Oct 2012]

ENSG00000119203 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000119203 CPSF3 0.43 2.00e-12 HNSC
ENSG00000119203 CPSF3 0.51 9.80e-26 BRCA
ENSG00000119203 CPSF3 0.79 5.29e-36 COAD
ENSG00000119203 CPSF3 1.08 5.82e-54 LUSC
ENSG00000119203 CPSF3 0.50 1.06e-14 LIHC
ENSG00000119203 CPSF3 1.07 7.64e-38 UCEC
ENSG00000119203 CPSF3 0.78 7.92e-33 LUAD
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000119203 CPSF3 tumor 25230976
ENSG00000119203 CPSF3 triple negative breast cancer 30360761
ENSG00000119203 CPSF3 ovarian cancer 30598658
ENSG00000119203 CPSF3 colorectal cancer 31186036
ENSG00000119203 CPSF3 non-small cell lung cancer 31452762
ENSG00000119203 CPSF3 cancer 31819276
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000119203 CPSF3 MESO 0.00085 high
ENSG00000119203 CPSF3 SARC 0.045 low
ENSG00000119203 CPSF3 UVM 0.0091 high
ENSG00000119203 CPSF3 UCEC 0.003 high
ENSG00000119203 CPSF3 LGG 0.029 high
ENSG00000119203 CPSF3 LUSC 0.012 low
ENSG00000119203 CPSF3 LUAD 0.024 high
ENSG00000119203 CPSF3 PCPG 7e-04 low
ENSG00000119203 CPSF3 THYM 0.0077 low
ENSG00000119203 CPSF3 BRCA 0.044 low
ENSG00000119203 CPSF3 OV 0.0083 low
ENSG00000119203 CPSF3 DLBC 0.0076 low
ENSG00000119203 CPSF3 KIRC 0.00016 high
ENSG00000119203 CPSF3 BLCA 0.012 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000119203 CPSF3 SARC Del 0.686930 0.119639 0.502878 0.350195
ENSG00000119203 CPSF3 LIHC Amp 1.060797 0.122360 0.512059 0.172973
ENSG00000119203 CPSF3 TGCT Amp 1.690985 0.162419 0.462090 0.380000
ENSG00000119203 CPSF3 UCEC Amp 1.231930 0.116418 0.596967 0.213358