Ensembl ID ENSG00000118495 Gene ID 5325 Accession 9046
Gene Symbol PLAGL1 Alias ZAC;LOT1;ZAC1 Full Name PLAG1 like zinc finger 1
Position 6 : 143940300 - 144064599 Length 124300 bases Strand Minus strand
Status Confidence Main interacting RNAsN.A.RBP type Canonical_RBPs
Summary This gene encodes a C2H2 zinc finger protein that functions as a suppressor of cell growth. This gene is often deleted or methylated and silenced in cancer cells. In addition, overexpression of this gene during fetal development is thought to be the causal factor for transient neonatal diabetes mellitus (TNDM). Alternative splicing and the use of alternative promoters results in multiple transcript variants encoding two different protein isoforms. The P1 downstream promoter of this gene is imprinted, with preferential expression from the paternal allele in many tissues. [provided by RefSeq, Nov 2015]

ENSG00000118495 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000118495 PLAGL1 1.22 4.29e-28 KIRC
ENSG00000118495 PLAGL1 -1.6 1.19e-46 BRCA
ENSG00000118495 PLAGL1 -1.1 2.32e-17 LUAD
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000118495 PLAGL1 ovarian cancer 10597250
ENSG00000118495 PLAGL1 tumor 11888928
ENSG00000118495 PLAGL1 tumor 12473647
ENSG00000118495 PLAGL1 renal cancers 12767066
ENSG00000118495 PLAGL1 tumor 15560839
ENSG00000118495 PLAGL1 ovarian cancer 15581945
ENSG00000118495 PLAGL1 tumor 16054751
ENSG00000118495 PLAGL1 tumors 16112421
ENSG00000118495 PLAGL1 tumor 16367923
ENSG00000118495 PLAGL1 tumors 16552773
ENSG00000118495 PLAGL1 ovarian cancer 16575187
ENSG00000118495 PLAGL1 tumor 16989664
ENSG00000118495 PLAGL1 cancers 17063461
ENSG00000118495 PLAGL1 tumour 17332914
ENSG00000118495 PLAGL1 tumour 17341487
ENSG00000118495 PLAGL1 cervical cancer 18217980
ENSG00000118495 PLAGL1 tumor 19489030
ENSG00000118495 PLAGL1 tumor 19637311
ENSG00000118495 PLAGL1 tumor 20175198
ENSG00000118495 PLAGL1 tumor 20696777
ENSG00000118495 PLAGL1 pituitary tumors 21810943
ENSG00000118495 PLAGL1 Tumor 21872827
ENSG00000118495 PLAGL1 tumor 21901247
ENSG00000118495 PLAGL1 cancers 22289848
ENSG00000118495 PLAGL1 tumour 22723905
ENSG00000118495 PLAGL1 cancer 23477525
ENSG00000118495 PLAGL1 ovarian cancer 23660957
ENSG00000118495 PLAGL1 tumor 23890537
ENSG00000118495 PLAGL1 tumor 24260468
ENSG00000118495 PLAGL1 ovarian cancer 25079112
ENSG00000118495 PLAGL1 cancers 25091631
ENSG00000118495 PLAGL1 prostate cancer 25926947
ENSG00000118495 PLAGL1 colorectal cancer 26134521
ENSG00000118495 PLAGL1 invasive breast cancer 26347357
ENSG00000118495 PLAGL1 prostate cancer 26710718
ENSG00000118495 PLAGL1 tumor 26851016
ENSG00000118495 PLAGL1 tumor 28791367
ENSG00000118495 PLAGL1 cancers 28957425
ENSG00000118495 PLAGL1 tumor 28985358
ENSG00000118495 PLAGL1 tumor 29084941
ENSG00000118495 PLAGL1 liver cancer 30214684
ENSG00000118495 PLAGL1 differentiated thyroid cancer 30820872
ENSG00000118495 PLAGL1 ovarian cancer 9150364
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000118495 PLAGL1 MESO 0.00076 high
ENSG00000118495 PLAGL1 SARC 0.017 high
ENSG00000118495 PLAGL1 STAD 0.0012 high
ENSG00000118495 PLAGL1 CHOL 0.03 high
ENSG00000118495 PLAGL1 UVM 0.032 high
ENSG00000118495 PLAGL1 PAAD 0.0024 low
ENSG00000118495 PLAGL1 THCA 0.0043 high
ENSG00000118495 PLAGL1 ACC 0.00042 low
ENSG00000118495 PLAGL1 KIRP 0.0035 high
ENSG00000118495 PLAGL1 BRCA 0.008 low
ENSG00000118495 PLAGL1 COAD 0.024 low
ENSG00000118495 PLAGL1 UCS 0.00074 low
ENSG00000118495 PLAGL1 OV 0.05 high
ENSG00000118495 PLAGL1 KIRC 0.02 high
ENSG00000118495 PLAGL1 TGCT 0.041 high
ENSG00000118495 PLAGL1 BLCA 0.00096 high
ENSG00000118495 PLAGL1 LAML 0.012 low
ENSG00000118495 PLAGL1 GBM 0.027 high
ENSG00000118495 PLAGL1 SKCM 0.0068 low
ENSG00000118495 PLAGL1 CESC 0.00042 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000118495 PLAGL1 LUAD Del 0.794964 0.052454 0.373911 0.486434
ENSG00000118495 PLAGL1 LGG Del 2.014823 0.052550 0.578645 0.157895
ENSG00000118495 PLAGL1 SARC Amp 6.790859 0.515976 1.134136 0.276265
ENSG00000118495 PLAGL1 GBM Del 5.421002 0.095881 0.554228 0.280763
ENSG00000118495 PLAGL1 SKCM Del 4.428290 0.116230 0.559221 0.596730
ENSG00000118495 PLAGL1 LIHC Del 2.983502 0.098609 0.598870 0.359459
ENSG00000118495 PLAGL1 DLBC Del 0.666956 0.121798 0.569645 0.270833
ENSG00000118495 PLAGL1 BRCA Del 0.852613 0.064859 0.463350 0.301852
ENSG00000118495 PLAGL1 MESO Del 1.488986 0.156798 0.534579 0.459770
ENSG00000118495 PLAGL1 KIRC Del 6.963938 0.054748 0.460344 0.285985
ENSG00000118495 PLAGL1 UVM Del 1.596523 0.092025 0.841737 0.287500
ENSG00000118495 PLAGL1 OV Del 16.091962 0.352656 0.624423 0.620035