Ensembl ID ENSG00000117751 Gene ID 5511 Accession 9296
Gene Symbol PPP1R8 Alias ARD1;ARD-1;NIPP1;NIPP-1;PRO2047 Full Name protein phosphatase 1 regulatory subunit 8
Position 1 : 27830782 - 27851676 Length 20895 bases Strand Plus strand
Status Confidence Main interacting RNAsdiverseRBP type Non-canonical_RBPs
Summary This gene, through alternative splicing, encodes three different isoforms. Two of the protein isoforms encoded by this gene are specific inhibitors of type 1 serine/threonine protein phosphatases and can bind but not cleave RNA. The third protein isoform lacks the phosphatase inhibitory function but is a single-strand endoribonuclease comparable to RNase E of E. coli. This isoform requires magnesium for its function and cleaves specific sites in A+U-rich regions of RNA. [provided by RefSeq, Jul 2008]

ENSG00000117751 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000117751 PPP1R8 -0.5 8.98e-18 KICH
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000117751 PPP1R8 cancer 22815811
ENSG00000117751 PPP1R8 cancer 24629090
ENSG00000117751 PPP1R8 tumor 26542020
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000117751 PPP1R8 MESO 0.029 high
ENSG00000117751 PPP1R8 SARC 0.00016 high
ENSG00000117751 PPP1R8 STAD 0.037 low
ENSG00000117751 PPP1R8 PAAD 0.029 low
ENSG00000117751 PPP1R8 UCEC 0.022 low
ENSG00000117751 PPP1R8 THCA 0.045 low
ENSG00000117751 PPP1R8 ACC 0.00032 high
ENSG00000117751 PPP1R8 LGG 0.00013 high
ENSG00000117751 PPP1R8 LUSC 0.035 low
ENSG00000117751 PPP1R8 HNSC 0.0086 high
ENSG00000117751 PPP1R8 KICH 0.0065 high
ENSG00000117751 PPP1R8 THYM 0.00065 low
ENSG00000117751 PPP1R8 BRCA 0.032 low
ENSG00000117751 PPP1R8 COAD 0.011 low
ENSG00000117751 PPP1R8 KIRC 0.00015 low
ENSG00000117751 PPP1R8 PRAD 0.015 low
ENSG00000117751 PPP1R8 TGCT 0.027 high
ENSG00000117751 PPP1R8 BLCA 0.011 low
ENSG00000117751 PPP1R8 LAML 0.023 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000117751 PPP1R8 CHOL Del 19.700240 1.019495 0.689078 0.777778
ENSG00000117751 PPP1R8 LUSC Del 2.658320 0.090545 0.380943 0.425150
ENSG00000117751 PPP1R8 LUAD Del 1.245459 0.058748 0.286056 0.244186
ENSG00000117751 PPP1R8 CESC Del 1.264366 0.078538 0.445211 0.108475
ENSG00000117751 PPP1R8 KIRP Del 6.491932 0.076312 0.594665 0.177083
ENSG00000117751 PPP1R8 READ Del 8.653354 0.211281 0.447192 0.454545
ENSG00000117751 PPP1R8 COAD Del 18.734472 0.161317 0.453768 0.359202
ENSG00000117751 PPP1R8 GBM Del 2.747197 0.074491 0.516340 0.081456
ENSG00000117751 PPP1R8 PAAD Del 3.387304 0.092378 0.354994 0.347826
ENSG00000117751 PPP1R8 ESCA Del 1.741220 0.125917 0.352460 0.385870
ENSG00000117751 PPP1R8 HNSC Del 1.418175 0.062636 0.355615 0.172414
ENSG00000117751 PPP1R8 LIHC Del 16.335628 0.211556 0.543414 0.378378
ENSG00000117751 PPP1R8 PCPG Del 1.823678 0.081533 0.674936 0.629630
ENSG00000117751 PPP1R8 BLCA Del 0.883548 0.080137 0.307745 0.208333
ENSG00000117751 PPP1R8 BRCA Del 28.673017 0.173324 0.418499 0.407407
ENSG00000117751 PPP1R8 STAD Del 6.514093 0.121031 0.364109 0.272109
ENSG00000117751 PPP1R8 UCEC Del 9.005696 0.113889 0.495300 0.135436
ENSG00000117751 PPP1R8 MESO Del 2.472987 0.194130 0.532818 0.275862
ENSG00000117751 PPP1R8 KIRC Del 7.446402 0.057003 0.421344 0.185606
ENSG00000117751 PPP1R8 UVM Del 1.063142 0.073079 0.771498 0.312500
ENSG00000117751 PPP1R8 OV Del 25.870651 0.422963 0.558027 0.421416