Ensembl ID
ENSG00000117593
Gene ID
55157
Accession
25538
Gene Symbol
DARS2
Alias
LBSL;ASPRS;mtAspRS;MT-ASPRS
Full Name
aspartyl-tRNA synthetase 2, mitochondrial
Position
1 : 173824653 - 173858808
Length
34156 bases
Strand
Plus strand
Status
Confidence
Main interacting RNAs tRNA RBP type
Canonical_RBPs
Summary
The protein encoded by this gene belongs to the class-II aminoacyl-tRNA synthetase family. It is a mitochondrial enzyme that specifically aminoacylates aspartyl-tRNA. Mutations in this gene are associated with leukoencephalopathy with brainstem and spinal cord involvement and lactate elevation (LBSL). [provided by RefSeq, Nov 2009]
ENSG00000117593 Expression In 33 Tumors
Ensembl ID
Gene symbol
Log2 Foldchange
Pvaue
Cancer
ENSG00000117593
DARS2
-0.8
5.03e-34
KIRC
ENSG00000117593
DARS2
0.63
8.27e-12
HNSC
ENSG00000117593
DARS2
1.18
4.23e-12
BLCA
ENSG00000117593
DARS2
0.98
2.87e-47
BRCA
ENSG00000117593
DARS2
1.39
6.42e-46
LUSC
ENSG00000117593
DARS2
0.79
3.43e-17
LIHC
ENSG00000117593
DARS2
1.11
4.25e-16
STAD
ENSG00000117593
DARS2
1.49
5.22e-40
UCEC
ENSG00000117593
DARS2
2.25
6.03e-11
CESC
ENSG00000117593
DARS2
1.21
1.69e-38
LUAD
Ensembl ID
Gene symbol
Cancer types
Pubmed ID
ENSG00000117593
DARS2
tumor disease
29052520
Ensembl ID
Gene symbol
Disease/phenotype
Mutation type
Mutated / Total samples
Literature
Ensembl ID
Gene symbol
Cancer
P-value
Which worse
show
ENSG00000117593
DARS2
SARC
0.002
high
show
ENSG00000117593
DARS2
UVM
0.0068
high
show
ENSG00000117593
DARS2
PAAD
0.004
high
show
ENSG00000117593
DARS2
UCEC
0.0062
high
show
ENSG00000117593
DARS2
ACC
0.035
high
show
ENSG00000117593
DARS2
HNSC
0.0089
high
show
ENSG00000117593
DARS2
READ
0.045
low
show
ENSG00000117593
DARS2
KIRP
0.019
high
show
ENSG00000117593
DARS2
KICH
0.0019
high
show
ENSG00000117593
DARS2
LUAD
0.0037
high
show
ENSG00000117593
DARS2
BRCA
0.03
high
show
ENSG00000117593
DARS2
COAD
0.013
high
show
ENSG00000117593
DARS2
BLCA
0.00042
high
show
ENSG00000117593
DARS2
LAML
0.023
high
show
ENSG00000117593
DARS2
SKCM
0.0025
high
show
ENSG00000117593
DARS2
CESC
0.041
high
show
ENSG00000117593
DARS2
LIHC
0.00078
high
show
Ensembl ID
Gene symbol
Cancer
CNV type
-log10(q-value)
G-score
average amplitude
frequency
ENSG00000117593
DARS2
LUSC
Amp
1.227187
0.211989
0.522989
0.508982
ENSG00000117593
DARS2
LUAD
Amp
1.860872
0.146395
0.505990
0.711240
ENSG00000117593
DARS2
CESC
Amp
0.703034
0.128074
0.608109
0.532203
ENSG00000117593
DARS2
SARC
Amp
4.385617
0.431242
0.777969
0.346304
ENSG00000117593
DARS2
SKCM
Amp
2.178857
0.166722
0.702770
0.534060
ENSG00000117593
DARS2
LIHC
Amp
7.712636
0.253696
0.873850
0.737838
ENSG00000117593
DARS2
DLBC
Amp
2.314444
0.347570
0.632214
0.312500
ENSG00000117593
DARS2
BLCA
Amp
6.643527
0.324764
0.575695
0.446078
ENSG00000117593
DARS2
BRCA
Amp
4.012033
0.199178
0.758518
0.734259
ENSG00000117593
DARS2
UCEC
Amp
1.846267
0.129812
0.822267
0.437848
ENSG00000117593
DARS2
OV
Amp
1.623764
0.362093
0.668659
0.549223
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