Ensembl ID ENSG00000116750 Gene ID 51377 Accession 19678
Gene Symbol UCHL5 Alias UCH37;CGI-70;INO80R;UCH-L5 Full Name ubiquitin C-terminal hydrolase L5
Position 1 : 193012250 - 193060080 Length 47831 bases Strand Minus strand
Status Confidence Main interacting RNAsN.A.RBP type Non-canonical_RBPs
Summary Enables endopeptidase inhibitor activity; proteasome binding activity; and thiol-dependent deubiquitinase. Involved in negative regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of smoothened signaling pathway; and protein deubiquitination. Located in cytosol; nucleolus; and nucleoplasm. Colocalizes with Ino80 complex. [provided by Alliance of Genome Resources, Apr 2022]

ENSG00000116750 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000116750 UCHL5 -0.3 5.28e-13 KIRC
ENSG00000116750 UCHL5 0.59 5.85e-27 BRCA
ENSG00000116750 UCHL5 0.64 5.44e-19 LUSC
ENSG00000116750 UCHL5 -1.0 3.95e-13 GBM
ENSG00000116750 UCHL5 0.65 6.07e-21 LUAD
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000116750 UCHL5 tumor 16402389
ENSG00000116750 UCHL5 cancer 17118327
ENSG00000116750 UCHL5 tumor 20302916
ENSG00000116750 UCHL5 cancer 21187158
ENSG00000116750 UCHL5 breast cancer 21851340
ENSG00000116750 UCHL5 tumor 22615012
ENSG00000116750 UCHL5 tumor 23725108
ENSG00000116750 UCHL5 cancer 24465953
ENSG00000116750 UCHL5 tumor 24912524
ENSG00000116750 UCHL5 cancer 24977961
ENSG00000116750 UCHL5 epithelial ovarian cancer 25123264
ENSG00000116750 UCHL5 cancer 25444757
ENSG00000116750 UCHL5 tumour 25691154
ENSG00000116750 UCHL5 cancer 25991664
ENSG00000116750 UCHL5 cancer 26097878
ENSG00000116750 UCHL5 cancer 26183292
ENSG00000116750 UCHL5 tumors 26396186
ENSG00000116750 UCHL5 cancer 26625200
ENSG00000116750 UCHL5 cancer 27086925
ENSG00000116750 UCHL5 DLBCL 27301795
ENSG00000116750 UCHL5 cancer 27604640
ENSG00000116750 UCHL5 tumor 27813535
ENSG00000116750 UCHL5 cancer 28598414
ENSG00000116750 UCHL5 cancer 28619062
ENSG00000116750 UCHL5 cancer 28653876
ENSG00000116750 UCHL5 rectal cancer 28681694
ENSG00000116750 UCHL5 cancer 28968984
ENSG00000116750 UCHL5 cancers 28992318
ENSG00000116750 UCHL5 tumor 29080080
ENSG00000116750 UCHL5 breast cancer 29353883
ENSG00000116750 UCHL5 tumor 29474458
ENSG00000116750 UCHL5 cancer 29698671
ENSG00000116750 UCHL5 gastric cancer 29718984
ENSG00000116750 UCHL5 colon cancer 30149015
ENSG00000116750 UCHL5 cancer 30527624
ENSG00000116750 UCHL5 breast cancer 30605979
ENSG00000116750 UCHL5 cancers 31064842
ENSG00000116750 UCHL5 ovarian cancer 31666925
ENSG00000116750 UCHL5 DLBCL 31694672
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000116750 UCHL5 UVM 0.001 high
ENSG00000116750 UCHL5 PAAD 0.005 high
ENSG00000116750 UCHL5 UCEC 0.012 high
ENSG00000116750 UCHL5 LGG 0.0018 low
ENSG00000116750 UCHL5 KICH 0.00082 high
ENSG00000116750 UCHL5 LUAD 0.0046 high
ENSG00000116750 UCHL5 PCPG 0.021 high
ENSG00000116750 UCHL5 THYM 0.048 low
ENSG00000116750 UCHL5 BRCA 0.032 low
ENSG00000116750 UCHL5 ESCA 0.043 high
ENSG00000116750 UCHL5 OV 0.00074 low
ENSG00000116750 UCHL5 DLBC 0.016 high
ENSG00000116750 UCHL5 KIRC 0.00067 low
ENSG00000116750 UCHL5 PRAD 0.0032 low
ENSG00000116750 UCHL5 BLCA 0.037 high
ENSG00000116750 UCHL5 LAML 0.025 high
ENSG00000116750 UCHL5 GBM 0.019 low
ENSG00000116750 UCHL5 SKCM 0.00077 low
ENSG00000116750 UCHL5 CESC 0.0018 high
ENSG00000116750 UCHL5 LIHC 0.038 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000116750 UCHL5 LUAD Amp 0.696237 0.116594 0.498230 0.703488
ENSG00000116750 UCHL5 SKCM Amp 2.275261 0.169522 0.711960 0.536785
ENSG00000116750 UCHL5 LIHC Amp 4.956147 0.206109 0.873203 0.721622
ENSG00000116750 UCHL5 DLBC Amp 2.314444 0.342879 0.614908 0.333333
ENSG00000116750 UCHL5 BLCA Amp 1.443137 0.191653 0.531143 0.370098
ENSG00000116750 UCHL5 BRCA Amp 5.071039 0.212602 0.764661 0.746296