Ensembl ID ENSG00000116717 Gene ID 1647 Accession 4095
Gene Symbol GADD45A Alias DDIT1;GADD45 Full Name growth arrest and DNA damage inducible alpha
Position 1 : 67685201 - 67688334 Length 3134 bases Strand Plus strand
Status Confidence Main interacting RNAsN.A.RBP type Canonical_RBPs
Summary This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The protein encoded by this gene responds to environmental stresses by mediating activation of the p38/JNK pathway via MTK1/MEKK4 kinase. The DNA damage-induced transcription of this gene is mediated by both p53-dependent and -independent mechanisms. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[provided by RefSeq, Dec 2010]

ENSG00000116717 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000116717 -0.7 5.86e-12 KIRC
ENSG00000116717 -0.9 1.18e-15 PRAD
ENSG00000116717 -0.9 6.07e-11 LIHC
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000116717 cancer 10327059
ENSG00000116717 breast cancer 10910365
ENSG00000116717 tumor 10962562
ENSG00000116717 tumour 11063132
ENSG00000116717 tumors 11471486
ENSG00000116717 pituitary tumor 11889197
ENSG00000116717 tumor 12170778
ENSG00000116717 bladder cancer 12175543
ENSG00000116717 myeloid tumor 12456288
ENSG00000116717 tumor 12579308
ENSG00000116717 tumour 12584164
ENSG00000116717 non-small cell lung cancer 12878869
ENSG00000116717 tumor 1423616
ENSG00000116717 ovarian cancer 14506229
ENSG00000116717 tumor 14672412
ENSG00000116717 breast cancer 15064713
ENSG00000116717 cancer 15270080
ENSG00000116717 cancer 15353598
ENSG00000116717 tumours 15377844
ENSG00000116717 breast cancer 15492278
ENSG00000116717 cancer 15613850
ENSG00000116717 ovarian cancer 15671562
ENSG00000116717 gastric cancer 15837757
ENSG00000116717 malignant ovarian tumors 15882169
ENSG00000116717 tumor 15920752
ENSG00000116717 colon cancer 15961301
ENSG00000116717 cancer 16010435
ENSG00000116717 tumor 16157202
ENSG00000116717 cancer 16166414
ENSG00000116717 cancers 16207477
ENSG00000116717 tumor 16260267
ENSG00000116717 pituitary tumor 16311409
ENSG00000116717 tumors 16520149
ENSG00000116717 ovarian cancer 16712459
ENSG00000116717 cancer 17116751
ENSG00000116717 tumor 17163161
ENSG00000116717 prostate cancer 17280610
ENSG00000116717 cervical cancer 17374990
ENSG00000116717 breast cancer 17428466
ENSG00000116717 cancer 17436581
ENSG00000116717 tumor 17607914
ENSG00000116717 tumors 17700520
ENSG00000116717 breast cancer 17764113
ENSG00000116717 pancreatic cancer 17940512
ENSG00000116717 breast cancer 18350249
ENSG00000116717 tumor 18472964
ENSG00000116717 thyroid cancers 18845647
ENSG00000116717 cancer 18847459
ENSG00000116717 tumor 18959781
ENSG00000116717 tumour 18978177
ENSG00000116717 tumor 19077262
ENSG00000116717 bladder cancer 19082486
ENSG00000116717 tumour 19382019
ENSG00000116717 tumor 19714865
ENSG00000116717 familial breast cancers 19728081
ENSG00000116717 colon cancer 20043265
ENSG00000116717 pancreatic cancers 20111973
ENSG00000116717 cancer 20190809
ENSG00000116717 colon cancer 20444249
ENSG00000116717 tumors 20652500
ENSG00000116717 cancer 20686221
ENSG00000116717 prostate cancer 20739400
ENSG00000116717 cancer 21048853
ENSG00000116717 breast tumor 21120602
ENSG00000116717 lung cancer 21199169
ENSG00000116717 cancer 21361780
ENSG00000116717 breast cancer 21455577
ENSG00000116717 breast cancer 21568272
ENSG00000116717 tumor 21607682
ENSG00000116717 tumor 21610151
ENSG00000116717 cancer 21614932
ENSG00000116717 prostate cancer 21734453
ENSG00000116717 AML 21739277
ENSG00000116717 tumor 21810943
ENSG00000116717 tumor 21850407
ENSG00000116717 ovarian cancer 21931671
ENSG00000116717 liver tumor 22008536
ENSG00000116717 tumors 22313682
ENSG00000116717 prostate cancer 22399598
ENSG00000116717 tumor 22433385
ENSG00000116717 tumor 22515981
ENSG00000116717 ovarian cancer 22900074
ENSG00000116717 breast cancer 22905241
ENSG00000116717 tumor 23053941
ENSG00000116717 tumor 23110523
ENSG00000116717 tumor 23110778
ENSG00000116717 tumour 23114628
ENSG00000116717 prostate cancer 23178451
ENSG00000116717 breast cancer 23313378
ENSG00000116717 tumor 23335992
ENSG00000116717 tumor 23536762
ENSG00000116717 cancer 23563151
ENSG00000116717 tumor 23616123
ENSG00000116717 cancer 23681232
ENSG00000116717 breast cancer 23824011
ENSG00000116717 liver cancer 24038948
ENSG00000116717 cancer 24351910
ENSG00000116717 tumor 24396688
ENSG00000116717 tumor 24403230
ENSG00000116717 prostate cancer 24447148
ENSG00000116717 tumors 24573956
ENSG00000116717 GBM 24577085
ENSG00000116717 colorectal cancer 24763055
ENSG00000116717 tumor 24872428
ENSG00000116717 tumor 24931005
ENSG00000116717 tumor 24942805
ENSG00000116717 tumor 24955130
ENSG00000116717 gastric cancer 25015188
ENSG00000116717 tumor 25087872
ENSG00000116717 tumour 25126861
ENSG00000116717 tumor 25245461
ENSG00000116717 tumors 25268703
ENSG00000116717 Cancer 25314072
ENSG00000116717 Cancer 25314077
ENSG00000116717 pituitary tumor 25446387
ENSG00000116717 Tumor 25846475
ENSG00000116717 tumors 25912017
ENSG00000116717 tumor 25944687
ENSG00000116717 lung cancer 26124921
ENSG00000116717 tumor 26172295
ENSG00000116717 cancer 26264004
ENSG00000116717 Ovarian Cancer 26422378
ENSG00000116717 tumor 26518708
ENSG00000116717 tumour 26545365
ENSG00000116717 tumor 26636486
ENSG00000116717 tumor 26655928
ENSG00000116717 cancer 26731607
ENSG00000116717 cancer 26732534
ENSG00000116717 tumor 26733164
ENSG00000116717 tumor 26819642
ENSG00000116717 esophageal cancer 26870203
ENSG00000116717 cancer 26874726
ENSG00000116717 cancer 26885618
ENSG00000116717 gastric cancer 26890145
ENSG00000116717 tumor 26913956
ENSG00000116717 non-small cell lung cancer 26993769
ENSG00000116717 Cancer 27066162
ENSG00000116717 tumor 27180883
ENSG00000116717 tumor 27381636
ENSG00000116717 cancers 27441658
ENSG00000116717 GBM 27533246
ENSG00000116717 Cervical Cancer 27626412
ENSG00000116717 tumor 27655697
ENSG00000116717 cancer 27658347
ENSG00000116717 breast cancer 27698914
ENSG00000116717 cancer 27888805
ENSG00000116717 tumor 28052097
ENSG00000116717 Colorectal Cancer 28068431
ENSG00000116717 cancer 28096969
ENSG00000116717 tumors 28097640
ENSG00000116717 gastric cancer 28190297
ENSG00000116717 cancer 28212646
ENSG00000116717 breast cancer 28280414
ENSG00000116717 tumors 28445981
ENSG00000116717 breast cancer 28503091
ENSG00000116717 Bladder Cancer 28577130
ENSG00000116717 non-small-cell lung cancer 28769054
ENSG00000116717 breast cancer 28780472
ENSG00000116717 cancers 28821714
ENSG00000116717 tumor 28870783
ENSG00000116717 tumor 28919782
ENSG00000116717 tumor 28992291
ENSG00000116717 cancer 29228625
ENSG00000116717 cancer 29277662
ENSG00000116717 Cancer 29279355
ENSG00000116717 Tumor 29386013
ENSG00000116717 tumor 29443889
ENSG00000116717 tumor 29472532
ENSG00000116717 head and neck cancer 29474504
ENSG00000116717 cancer 29511335
ENSG00000116717 cancer 29515153
ENSG00000116717 cancer 29572137
ENSG00000116717 cervical cancer 29743554
ENSG00000116717 endometrial cancer 29760790
ENSG00000116717 prostate cancer 29850926
ENSG00000116717 breast cancer 29854295
ENSG00000116717 hereditary breast cancer 29858376
ENSG00000116717 breast cancer 30128181
ENSG00000116717 tumor 30157901
ENSG00000116717 cancer 30177839
ENSG00000116717 cancer 30467642
ENSG00000116717 lung cancer 30539533
ENSG00000116717 tumor 30643065
ENSG00000116717 tumor 30669496
ENSG00000116717 Tumor 30895393
ENSG00000116717 brain cancer 30912292
ENSG00000116717 tumor 30961474
ENSG00000116717 pancreatic cancer 31075266
ENSG00000116717 cancer 31080744
ENSG00000116717 tumor 31101653
ENSG00000116717 cancer 31114253
ENSG00000116717 tumor 31131003
ENSG00000116717 tumor 31380287
ENSG00000116717 cancer 31549646
ENSG00000116717 tumor 31666445
ENSG00000116717 cancer 31860949
ENSG00000116717 tumor 31933796
ENSG00000116717 cancer 7478567
ENSG00000116717 tumour 7566179
ENSG00000116717 tumor 8168107
ENSG00000116717 tumour 8570197
ENSG00000116717 tumor 8631022
ENSG00000116717 breast cancers 8834260
ENSG00000116717 colon cancer 8938795
ENSG00000116717 tumor 9406706
ENSG00000116717 tumor 9545797
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000116717 SARC 0.032 high
ENSG00000116717 STAD 0.04 low
ENSG00000116717 PAAD 0.027 high
ENSG00000116717 UCEC 0.0022 low
ENSG00000116717 THCA 0.0054 low
ENSG00000116717 HNSC 0.011 high
ENSG00000116717 LUAD 0.015 high
ENSG00000116717 PCPG 0.0018 high
ENSG00000116717 THYM 0.0065 high
ENSG00000116717 BRCA 0.012 low
ENSG00000116717 COAD 0.045 high
ENSG00000116717 SKCM 0.00019 low
ENSG00000116717 CESC 0.028 high
ENSG00000116717 LIHC 0.00092 low
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000116717 COAD Del 3.475281 0.069136 0.418365 0.283814
ENSG00000116717 PCPG Del 9.478384 0.185120 0.685786 0.722222
ENSG00000116717 UVM Del 1.063142 0.074432 0.841090 0.275000