Ensembl ID ENSG00000116698 Gene ID 9887 Accession 16792
Gene Symbol SMG7 Alias EST1C;SGA56M;C1orf16 Full Name SMG7 nonsense mediated mRNA decay factor
Position 1 : 183472216 - 183554193 Length 81978 bases Strand Plus strand
Status Confidence Main interacting RNAsmRNARBP type Canonical_RBPs
Summary This gene encodes a protein that is essential for nonsense-mediated mRNA decay (NMD); a process whereby transcripts with premature termination codons are targeted for rapid degradation by a mRNA decay complex. The mRNA decay complex consists, in part, of this protein along with proteins SMG5 and UPF1. The N-terminal domain of this protein is thought to mediate its association with SMG5 or UPF1 while the C-terminal domain interacts with the mRNA decay complex. This protein may therefore couple changes in UPF1 phosphorylation state to the degradation of NMD-candidate transcripts. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Aug 2011]

ENSG00000116698 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000116698 SMG7 0.63 4.12e-11 BLCA
ENSG00000116698 SMG7 0.72 1.96e-62 BRCA
ENSG00000116698 SMG7 0.78 1.32e-27 LUSC
ENSG00000116698 SMG7 0.50 5.00e-14 LIHC
ENSG00000116698 SMG7 0.50 1.02e-11 UCEC
ENSG00000116698 SMG7 0.58 3.00e-23 LUAD
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000116698 SMG7 tumor 29262850
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000116698 SMG7 MESO 0.0092 high
ENSG00000116698 SMG7 SARC 0.029 high
ENSG00000116698 SMG7 STAD 0.028 low
ENSG00000116698 SMG7 UCEC 0.0017 high
ENSG00000116698 SMG7 THCA 0.026 high
ENSG00000116698 SMG7 ACC 6e-04 high
ENSG00000116698 SMG7 LUSC 0.0054 low
ENSG00000116698 SMG7 READ 0.041 high
ENSG00000116698 SMG7 KIRP 0.0023 high
ENSG00000116698 SMG7 LUAD 0.0072 high
ENSG00000116698 SMG7 BRCA 0.0059 high
ENSG00000116698 SMG7 KIRC 0.00028 low
ENSG00000116698 SMG7 TGCT 0.033 low
ENSG00000116698 SMG7 BLCA 0.001 high
ENSG00000116698 SMG7 LAML 0.016 high
ENSG00000116698 SMG7 GBM 0.0051 low
ENSG00000116698 SMG7 SKCM 0.00097 high
ENSG00000116698 SMG7 LIHC 0.0067 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000116698 SMG7 READ Amp 0.860215 0.132438 0.601366 0.296970
ENSG00000116698 SMG7 SARC Amp 2.057356 0.332020 0.760661 0.287938
ENSG00000116698 SMG7 SKCM Amp 1.165919 0.135765 0.685568 0.531335
ENSG00000116698 SMG7 LIHC Amp 4.290942 0.193752 0.865886 0.721622
ENSG00000116698 SMG7 DLBC Amp 2.314444 0.342879 0.614908 0.333333
ENSG00000116698 SMG7 BLCA Amp 3.087502 0.241855 0.540195 0.401961
ENSG00000116698 SMG7 BRCA Amp 5.361643 0.216080 0.769429 0.742593
ENSG00000116698 SMG7 UCEC Amp 1.754975 0.127870 0.823631 0.435993
ENSG00000116698 SMG7 OV Amp 4.719069 0.444494 0.715503 0.559585