Ensembl ID ENSG00000116688 Gene ID 9927 Accession 16877
Gene Symbol MFN2 Alias HSG;MSL;MARF;CMT2A;CPRP1;CMT2A2;HMSN6A;CMT2A2A;CMT2A2B Full Name mitofusin 2
Position 1 : 11980181 - 12015211 Length 35031 bases Strand Plus strand
Status Confidence Main interacting RNAsN.A.RBP type Canonical_RBPs
Summary This gene encodes a mitochondrial membrane protein that participates in mitochondrial fusion and contributes to the maintenance and operation of the mitochondrial network. This protein is involved in the regulation of vascular smooth muscle cell proliferation, and it may play a role in the pathophysiology of obesity. Mutations in this gene cause Charcot-Marie-Tooth disease type 2A2, and hereditary motor and sensory neuropathy VI, which are both disorders of the peripheral nervous system. Defects in this gene have also been associated with early-onset stroke. Two transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]

ENSG00000116688 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000116688 -0.7 6.89e-50 KIRC
ENSG00000116688 -0.8 6.57e-12 BLCA
ENSG00000116688 -0.3 3.18e-12 BRCA
ENSG00000116688 -0.7 2.28e-25 COAD
ENSG00000116688 -0.6 1.35e-39 PRAD
ENSG00000116688 -0.5 2.44e-11 LIHC
ENSG00000116688 -0.7 2.57e-14 STAD
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000116688 tumour 20803103
ENSG00000116688 breast cancer 23588792
ENSG00000116688 colorectal cancer 23906296
ENSG00000116688 tumor 24503793
ENSG00000116688 tumors 25796500
ENSG00000116688 cancers 26733181
ENSG00000116688 breast cancer 26788214
ENSG00000116688 tumors 26845057
ENSG00000116688 breast cancer 26888829
ENSG00000116688 lung cancer 27124102
ENSG00000116688 tumor 27313467
ENSG00000116688 breast cancer 27364555
ENSG00000116688 tumor 27389277
ENSG00000116688 cancer 27847330
ENSG00000116688 cancer 27895764
ENSG00000116688 cancer 28176801
ENSG00000116688 tumors 28435473
ENSG00000116688 tumor 28603693
ENSG00000116688 Cancer 28607589
ENSG00000116688 cancer 29491355
ENSG00000116688 ovarian cancer 29494264
ENSG00000116688 cancers 29587277
ENSG00000116688 cancers 29700304
ENSG00000116688 tumour 29848692
ENSG00000116688 tumor 29981809
ENSG00000116688 Pancreatic Cancer 30046371
ENSG00000116688 prostate cancer 30167092
ENSG00000116688 Tumor 30498519
ENSG00000116688 cancers of lung 30636894
ENSG00000116688 tumors 30887444
ENSG00000116688 liver cancer 30923462
ENSG00000116688 breast cancer 30932749
ENSG00000116688 cancer 31036292
ENSG00000116688 cancer 31104361
ENSG00000116688 bladder cancer 31402945
ENSG00000116688 breast cancer 31535669
ENSG00000116688 Cancer 31955176
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000116688 MESO 0.0032 low
ENSG00000116688 SARC 0.013 high
ENSG00000116688 PAAD 0.034 low
ENSG00000116688 UCEC 0.035 low
ENSG00000116688 THCA 0.01 high
ENSG00000116688 LGG 3e-04 high
ENSG00000116688 KIRP 0.0022 low
ENSG00000116688 KICH 0.048 high
ENSG00000116688 LUAD 0.024 low
ENSG00000116688 THYM 0.0016 high
ENSG00000116688 ESCA 0.038 low
ENSG00000116688 OV 0.014 high
ENSG00000116688 LAML 0.044 high
ENSG00000116688 GBM 0.049 low
ENSG00000116688 SKCM 0.0095 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000116688 CHOL Del 21.200587 1.073628 0.699355 0.805556
ENSG00000116688 LUSC Del 4.775284 0.111074 0.385807 0.443114
ENSG00000116688 CESC Del 2.711345 0.101659 0.453020 0.128814
ENSG00000116688 KIRP Del 6.779795 0.079319 0.590029 0.180556
ENSG00000116688 ACC Del 1.402449 0.126309 0.561275 0.377778
ENSG00000116688 READ Del 8.331013 0.204063 0.454617 0.436364
ENSG00000116688 COAD Del 12.360923 0.126509 0.442621 0.325942
ENSG00000116688 UCS Del 1.046000 0.231996 0.447550 0.303571
ENSG00000116688 SARC Del 3.660827 0.192518 0.672166 0.198444
ENSG00000116688 GBM Amp 1.317953 0.079161 0.500177 0.149047
ENSG00000116688 GBM Del 8.100814 0.113519 0.538077 0.114385
ENSG00000116688 PAAD Del 1.542654 0.062370 0.343774 0.298913
ENSG00000116688 SKCM Del 3.465724 0.105315 0.469650 0.201635
ENSG00000116688 HNSC Del 3.509404 0.081302 0.388854 0.176245
ENSG00000116688 LIHC Del 18.057054 0.223845 0.542352 0.389189
ENSG00000116688 PCPG Del 2.014534 0.085543 0.671907 0.623457
ENSG00000116688 TGCT Del 1.627567 0.078673 0.364504 0.213333
ENSG00000116688 BRCA Del 35.824911 0.192371 0.432250 0.411111
ENSG00000116688 STAD Del 2.089334 0.079787 0.331601 0.224490
ENSG00000116688 UCEC Del 6.502621 0.098824 0.509102 0.115028
ENSG00000116688 MESO Del 4.536144 0.255107 0.529711 0.344828
ENSG00000116688 KIRC Del 7.326534 0.056593 0.412422 0.189394
ENSG00000116688 UVM Del 1.063142 0.073079 0.795096 0.300000
ENSG00000116688 OV Del 16.292985 0.354152 0.553576 0.367876