Ensembl ID ENSG00000116560 Gene ID 6421 Accession 10774
Gene Symbol SFPQ Alias PSF;POMP100;PPP1R140 Full Name splicing factor proline and glutamine rich
Position 1 : 35176378 - 35193446 Length 17069 bases Strand Minus strand
Status Confidence Main interacting RNAsmRNARBP type Canonical_RBPs
Summary Enables DNA binding activity; histone deacetylase binding activity; and protein homodimerization activity. Involved in several processes, including alternative mRNA splicing, via spliceosome; positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway; and regulation of transcription by RNA polymerase II. Acts upstream of or within double-strand break repair via homologous recombination. Located in chromatin; nuclear matrix; and paraspeckles. [provided by Alliance of Genome Resources, Apr 2022]

ENSG00000116560 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000116560 SFPQ 0.34 2.98e-27 BRCA
ENSG00000116560 SFPQ 0.49 5.01e-22 COAD
ENSG00000116560 SFPQ 0.45 2.40e-16 LUSC
ENSG00000116560 SFPQ 0.41 3.53e-19 PRAD
ENSG00000116560 SFPQ 0.41 2.53e-12 UCEC
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000116560 SFPQ Perivascular epithelioid cell tumor 19606011
ENSG00000116560 SFPQ prostate cancer 20805891
ENSG00000116560 SFPQ cancer 20813759
ENSG00000116560 SFPQ colon cancer 23516550
ENSG00000116560 SFPQ prostate cancer 23737958
ENSG00000116560 SFPQ colon cancer 24288667
ENSG00000116560 SFPQ colorectal cancer 25025966
ENSG00000116560 SFPQ tumours 25048860
ENSG00000116560 SFPQ tumors 25651471
ENSG00000116560 SFPQ renal cancers 26274027
ENSG00000116560 SFPQ tumor 26307974
ENSG00000116560 SFPQ Pancreatic Cancer 26309807
ENSG00000116560 SFPQ renal cancers 26975036
ENSG00000116560 SFPQ tumor 27084935
ENSG00000116560 SFPQ tumor 27686732
ENSG00000116560 SFPQ tumor 28315422
ENSG00000116560 SFPQ breast cancer 28673861
ENSG00000116560 SFPQ cancer 28743736
ENSG00000116560 SFPQ cancer 29299133
ENSG00000116560 SFPQ colorectal cancer 29416704
ENSG00000116560 SFPQ tumor 29425321
ENSG00000116560 SFPQ malignant tumor 29928414
ENSG00000116560 SFPQ Colorectal Cancer 30026827
ENSG00000116560 SFPQ liver cancer 30254462
ENSG00000116560 SFPQ cancer 30377567
ENSG00000116560 SFPQ cancer 30719108
ENSG00000116560 SFPQ triple-negative breast cancer 30725116
ENSG00000116560 SFPQ cancer 30824709
ENSG00000116560 SFPQ tumour 30951404
ENSG00000116560 SFPQ liver cancer 31815296
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
ENSG00000116560 SFPQ breast ductal adenocarcinoma missense_variant 2.055% (12/584) 1 entry
ENSG00000116560 SFPQ colon adenocarcinoma missense_variant 0.9695% (7/722) 3 entries
ENSG00000116560 SFPQ prostate adenocarcinoma sequence_alteration 0.4814% (7/1454) 1 entry
ENSG00000116560 SFPQ melanoma missense_variant 1.98% (2/101) 1 entry
ENSG00000116560 SFPQ Mantle cell lymphoma sequence_alteration 4.878% (2/41) 1 entry
ENSG00000116560 SFPQ skin melanoma missense_variant 0.9307% (9/967) 4 entries
ENSG00000116560 SFPQ Merkel cell skin cancer missense_variant 6.667% (2/30) 2 entries
ENSG00000116560 SFPQ colorectal adenocarcinoma missense_variant 1.406% (16/1138) 3 entries
ENSG00000116560 SFPQ lung adenocarcinoma missense_variant 0.5155% (6/1164) 3 entries
ENSG00000116560 SFPQ renal carcinoma gene_fusion 18.18% (2/11) 2 entries
ENSG00000116560 SFPQ small cell lung carcinoma missense_variant 0.9404% (3/319) 2 entries
ENSG00000116560 SFPQ colon adenocarcinoma stop_gained 0.9695% (7/722) 1 entry
ENSG00000116560 SFPQ meningioma (disease) frameshift_variant 2.041% (1/49) 1 entry
ENSG00000116560 SFPQ chronic myelomonocytic leukemia missense_variant 1.205% (1/83) 1 entry
ENSG00000116560 SFPQ laryngeal squamous cell carcinoma missense_variant 3.846% (1/26) 1 entry
ENSG00000116560 SFPQ brain glioblastoma missense_variant 0.216% (2/926) 1 entry
ENSG00000116560 SFPQ acute myeloid leukemia missense_variant 0.1101% (1/908) 1 entry
ENSG00000116560 SFPQ cecum adenocarcinoma missense_variant 0.8% (1/125) 1 entry
ENSG00000116560 SFPQ prostate carcinoma missense_variant 0.4695% (2/426) 1 entry
ENSG00000116560 SFPQ Pleural Epithelioid Mesothelioma missense_variant 1.064% (1/94) 1 entry
ENSG00000116560 SFPQ Renal Cell Carcinoma Associated with Xp11.2 Translocations/TFE3 Gene Fusions gene_fusion 50.0% (1/2) 1 entry
ENSG00000116560 SFPQ head and neck squamous cell carcinoma missense_variant 0.1597% (1/626) 1 entry
ENSG00000116560 SFPQ colon adenocarcinoma sequence_alteration 0.9695% (7/722) 1 entry
ENSG00000116560 SFPQ ovarian serous adenocarcinoma conservative_inframe_deletion 0.1486% (1/673) 1 entry
ENSG00000116560 SFPQ large cell lung carcinoma missense_variant 5.556% (1/18) 1 entry
ENSG00000116560 SFPQ brain glioblastoma sequence_alteration 0.216% (2/926) 1 entry
ENSG00000116560 SFPQ neoplasm missense_variant 3.571% (1/28) 1 entry
ENSG00000116560 SFPQ colon adenocarcinoma frameshift_variant 0.9695% (7/722) 1 entry
ENSG00000116560 SFPQ non-small cell lung carcinoma missense_variant 1.887% (1/53) 1 entry
ENSG00000116560 SFPQ Invasive Breast Carcinoma missense_variant 2.174% (1/46) 1 entry
ENSG00000116560 SFPQ PEComa gene_fusion 50.0% (1/2) 1 entry
ENSG00000116560 SFPQ small cell lung carcinoma frameshift_variant 0.9404% (3/319) 1 entry
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000116560 SFPQ STAD 0.006 low
ENSG00000116560 SFPQ PAAD 0.019 low
ENSG00000116560 SFPQ THCA 0.022 low
ENSG00000116560 SFPQ HNSC 0.017 low
ENSG00000116560 SFPQ READ 0.00097 high
ENSG00000116560 SFPQ KIRP 0.0088 high
ENSG00000116560 SFPQ KICH 0.0046 high
ENSG00000116560 SFPQ THYM 0.00039 low
ENSG00000116560 SFPQ COAD 0.0065 low
ENSG00000116560 SFPQ UCS 0.0036 low
ENSG00000116560 SFPQ ESCA 0.02 high
ENSG00000116560 SFPQ PRAD 0.016 high
ENSG00000116560 SFPQ TGCT 0.0038 low
ENSG00000116560 SFPQ BLCA 0.0036 low
ENSG00000116560 SFPQ LAML 0.014 low
ENSG00000116560 SFPQ GBM 0.0089 high
ENSG00000116560 SFPQ SKCM 0.0054 low
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000116560 SFPQ CHOL Del 5.648354 0.511251 0.631028 0.472222
ENSG00000116560 SFPQ KIRP Del 3.837104 0.056012 0.586873 0.163194
ENSG00000116560 SFPQ READ Del 0.637830 0.068896 0.399054 0.345455
ENSG00000116560 SFPQ COAD Del 3.109616 0.066255 0.412498 0.288248
ENSG00000116560 SFPQ LIHC Del 5.332794 0.124944 0.514240 0.316216
ENSG00000116560 SFPQ PCPG Del 1.396821 0.072845 0.671612 0.617284
ENSG00000116560 SFPQ BRCA Del 1.573242 0.071274 0.386601 0.312963
ENSG00000116560 SFPQ UCEC Del 0.619137 0.046198 0.427582 0.076067
ENSG00000116560 SFPQ KIRC Del 1.606902 0.030552 0.415599 0.159091
ENSG00000116560 SFPQ UVM Del 2.306078 0.117738 0.814580 0.312500
ENSG00000116560 SFPQ OV Amp 2.886042 0.400012 0.632742 0.405872