Ensembl ID ENSG00000116251 Gene ID 6146 Accession 10315
Gene Symbol RPL22 Alias EAP;L22;eL22;HBP15;HBP15/L22 Full Name ribosomal protein L22
Position 1 : 6185020 - 6209389 Length 24370 bases Strand Minus strand
Status Confidence Main interacting RNAsrRNARBP type Canonical_RBPs
Summary Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a cytoplasmic ribosomal protein that is a component of the 60S subunit. The protein belongs to the L22E family of ribosomal proteins. Its initiating methionine residue is post-translationally removed. The protein can bind specifically to Epstein-Barr virus-encoded RNAs (EBERs) 1 and 2. The mouse protein has been shown to be capable of binding to heparin. Transcript variants utilizing alternative polyA signals exist. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. It was previously thought that this gene mapped to 3q26 and that it was fused to the acute myeloid leukemia 1 (AML1) gene located at 21q22 in some therapy-related myelodysplastic syndrome patients with 3;21 translocations; however, these fusions actually involve a ribosomal protein L22 pseudogene located at 3q26, and this gene actually maps to 1p36.3-p36.2. [provided by RefSeq, Jul 2008]

ENSG00000116251 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000116251 RPL22 -0.4 2.19e-17 BRCA
ENSG00000116251 RPL22 -0.9 1.82e-13 UCEC
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000116251 RPL22 tumour 10492640
ENSG00000116251 RPL22 tumor 20865127
ENSG00000116251 RPL22 tumors 23127973
ENSG00000116251 RPL22 gastric cancer 23237666
ENSG00000116251 RPL22 lung cancer 23797773
ENSG00000116251 RPL22 tumor 24504451
ENSG00000116251 RPL22 lung cancer 24840952
ENSG00000116251 RPL22 endometrial tumors 25196364
ENSG00000116251 RPL22 cancer 25469243
ENSG00000116251 RPL22 endometrial cancer 26892688
ENSG00000116251 RPL22 cancer 28147343
ENSG00000116251 RPL22 tumor 28264936
ENSG00000116251 RPL22 tumor 29163851
ENSG00000116251 RPL22 cancer 29207594
ENSG00000116251 RPL22 tumours 29546405
ENSG00000116251 RPL22 tumours 29682207
ENSG00000116251 RPL22 cancer 30874462
ENSG00000116251 RPL22 prostate cancer 30972102
ENSG00000116251 RPL22 tumour 31485773
ENSG00000116251 RPL22 colon cancer 31581233
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
ENSG00000116251 RPL22 colon adenocarcinoma missense_variant 3.463% (25/722) 1 entry
ENSG00000116251 RPL22 colon adenocarcinoma frameshift_variant 3.463% (25/722) 4 entries
ENSG00000116251 RPL22 colorectal adenocarcinoma frameshift_variant 4.833% (55/1138) 2 entries
ENSG00000116251 RPL22 colon adenocarcinoma sequence_alteration 3.463% (25/722) 4 entries
ENSG00000116251 RPL22 gastric intestinal type adenocarcinoma frameshift_variant 15.29% (13/85) 2 entries
ENSG00000116251 RPL22 colorectal adenocarcinoma sequence_alteration 4.833% (55/1138) 2 entries
ENSG00000116251 RPL22 gastric intestinal type adenocarcinoma sequence_alteration 15.29% (13/85) 2 entries
ENSG00000116251 RPL22 hepatocellular carcinoma sequence_alteration 0.8899% (8/899) 2 entries
ENSG00000116251 RPL22 prostate adenocarcinoma sequence_alteration 0.9629% (14/1454) 1 entry
ENSG00000116251 RPL22 prostate carcinoma sequence_alteration 0.9368% (4/427) 2 entries
ENSG00000116251 RPL22 T-cell acute lymphoblastic leukemia frameshift_variant 0.8011% (6/749) 3 entries
ENSG00000116251 RPL22 prostate carcinoma frameshift_variant 0.9368% (4/427) 2 entries
ENSG00000116251 RPL22 skin melanoma sequence_alteration 0.6205% (6/967) 2 entries
ENSG00000116251 RPL22 cecum adenocarcinoma sequence_alteration 2.4% (3/125) 1 entry
ENSG00000116251 RPL22 T-cell acute lymphoblastic leukemia sequence_alteration 0.8011% (6/749) 3 entries
ENSG00000116251 RPL22 pancreatic ductal adenocarcinoma missense_variant 0.7149% (9/1259) 1 entry
ENSG00000116251 RPL22 melanoma sequence_alteration 5.941% (6/101) 1 entry
ENSG00000116251 RPL22 gastric adenocarcinoma frameshift_variant 1.075% (6/558) 2 entries
ENSG00000116251 RPL22 cecum adenocarcinoma frameshift_variant 2.4% (3/125) 1 entry
ENSG00000116251 RPL22 prostate adenocarcinoma frameshift_variant 0.9629% (14/1454) 1 entry
ENSG00000116251 RPL22 skin melanoma missense_variant 0.6205% (6/967) 1 entry
ENSG00000116251 RPL22 gastric adenocarcinoma sequence_alteration 1.075% (6/558) 2 entries
ENSG00000116251 RPL22 clear cell renal carcinoma sequence_alteration 0.1451% (2/1378) 1 entry
ENSG00000116251 RPL22 pancreatic ductal adenocarcinoma sequence_alteration 0.7149% (9/1259) 1 entry
ENSG00000116251 RPL22 melanoma frameshift_variant 5.941% (6/101) 1 entry
ENSG00000116251 RPL22 melanoma missense_variant 5.941% (6/101) 1 entry
ENSG00000116251 RPL22 lung adenocarcinoma missense_variant 0.172% (2/1163) 1 entry
ENSG00000116251 RPL22 colorectal adenocarcinoma missense_variant 4.833% (55/1138) 1 entry
ENSG00000116251 RPL22 hepatocellular carcinoma frameshift_variant 0.8899% (8/899) 1 entry
ENSG00000116251 RPL22 basal cell carcinoma stop_gained 1.724% (1/58) 1 entry
ENSG00000116251 RPL22 primary peritoneal carcinoma (disease) frameshift_variant 100.0% (1/1) 1 entry
ENSG00000116251 RPL22 basal cell carcinoma missense_variant 1.724% (1/58) 1 entry
ENSG00000116251 RPL22 extragonadal germ cell cancer sequence_alteration 50.0% (1/2) 1 entry
ENSG00000116251 RPL22 melanoma stop_gained 5.941% (6/101) 1 entry
ENSG00000116251 RPL22 nasopharyngeal squamous cell carcinoma missense_variant 0.5988% (1/167) 1 entry
ENSG00000116251 RPL22 small cell lung carcinoma missense_variant 0.3135% (1/319) 1 entry
ENSG00000116251 RPL22 extragonadal germ cell cancer frameshift_variant 50.0% (1/2) 1 entry
ENSG00000116251 RPL22 lung adenocarcinoma sequence_alteration 0.172% (2/1163) 1 entry
ENSG00000116251 RPL22 primary peritoneal carcinoma (disease) sequence_alteration 100.0% (1/1) 1 entry
ENSG00000116251 RPL22 B-cell acute lymphoblastic leukemia missense_variant 1.852% (1/54) 1 entry
ENSG00000116251 RPL22 skin melanoma frameshift_variant 0.6205% (6/967) 1 entry
ENSG00000116251 RPL22 Unclassified Renal Cell Carcinoma missense_variant 6.667% (1/15) 1 entry
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000116251 RPL22 MESO 0.00044 low
ENSG00000116251 RPL22 SARC 1e-04 high
ENSG00000116251 RPL22 UVM 7e-04 low
ENSG00000116251 RPL22 UCEC 0.037 high
ENSG00000116251 RPL22 ACC 0.00034 high
ENSG00000116251 RPL22 LUSC 0.032 low
ENSG00000116251 RPL22 THYM 0.0036 low
ENSG00000116251 RPL22 BRCA 0.0035 low
ENSG00000116251 RPL22 ESCA 0.025 high
ENSG00000116251 RPL22 TGCT 0.024 high
ENSG00000116251 RPL22 LAML 0.011 low
ENSG00000116251 RPL22 GBM 0.031 low
ENSG00000116251 RPL22 SKCM 0.0074 high
ENSG00000116251 RPL22 LIHC 0.0028 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000116251 RPL22 CHOL Del 21.605518 1.088665 0.687147 0.833333
ENSG00000116251 RPL22 LUSC Del 6.048556 0.122311 0.385399 0.433134
ENSG00000116251 RPL22 LUAD Del 1.243783 0.058748 0.297337 0.230620
ENSG00000116251 RPL22 LGG Del 3.637652 0.065634 0.694338 0.415205
ENSG00000116251 RPL22 CESC Del 2.717568 0.102026 0.451703 0.128814
ENSG00000116251 RPL22 KIRP Del 8.835051 0.095484 0.601037 0.190972
ENSG00000116251 RPL22 ACC Del 3.612450 0.208109 0.582298 0.422222
ENSG00000116251 RPL22 READ Del 8.134805 0.200782 0.451172 0.430303
ENSG00000116251 RPL22 COAD Del 15.462454 0.143073 0.453798 0.332594
ENSG00000116251 RPL22 UCS Del 1.513310 0.272596 0.531948 0.303571
ENSG00000116251 RPL22 SARC Del 7.067897 0.250652 0.669240 0.241245
ENSG00000116251 RPL22 GBM Del 48.661766 0.294211 0.646352 0.228769
ENSG00000116251 RPL22 PAAD Del 1.283875 0.057663 0.343042 0.293478
ENSG00000116251 RPL22 SKCM Del 8.272008 0.154285 0.490109 0.217984
ENSG00000116251 RPL22 HNSC Del 4.173665 0.086280 0.393982 0.180077
ENSG00000116251 RPL22 LIHC Del 32.935299 0.318650 0.572716 0.443243
ENSG00000116251 RPL22 PCPG Del 3.284079 0.106928 0.675981 0.635802
ENSG00000116251 RPL22 TGCT Del 3.317598 0.111152 0.382969 0.226667
ENSG00000116251 RPL22 DLBC Del 1.581347 0.175931 0.484325 0.229167
ENSG00000116251 RPL22 BLCA Del 1.087991 0.084118 0.319730 0.198529
ENSG00000116251 RPL22 BRCA Del 34.492383 0.188762 0.432275 0.400000
ENSG00000116251 RPL22 STAD Del 3.533871 0.095254 0.349920 0.233560
ENSG00000116251 RPL22 UCEC Del 9.549588 0.117505 0.512032 0.129870
ENSG00000116251 RPL22 MESO Del 6.573926 0.311106 0.553318 0.379310
ENSG00000116251 RPL22 KIRC Del 7.982430 0.059259 0.410873 0.193182
ENSG00000116251 RPL22 OV Del 15.321817 0.346485 0.568272 0.352332