Ensembl ID ENSG00000115866 Gene ID 1615 Accession 2678
Gene Symbol DARS1 Alias DARS;HBSL;aspRS Full Name aspartyl-tRNA synthetase 1
Position 2 : 135905881 - 135986100 Length 80220 bases Strand Minus strand
Status Confidence Main interacting RNAstRNARBP type Canonical_RBPs
Summary This gene encodes a member of a multienzyme complex that functions in mediating the attachment of amino acids to their cognate tRNAs. The encoded protein ligates L-aspartate to tRNA(Asp). Mutations in this gene have been found in patients showing hypomyelination with brainstem and spinal cord involvement and leg spasticity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]

ENSG00000115866 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000115866 DARS1 1.04 2.59e-63 KIRC
ENSG00000115866 DARS1 0.88 2.88e-29 COAD
ENSG00000115866 DARS1 0.94 1.43e-35 LUSC
ENSG00000115866 DARS1 0.59 8.64e-20 LUAD
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000115866 DARS1 prostate cancer 25392686
ENSG00000115866 DARS1 ovarian cancer 30964159
ENSG00000115866 DARS1 non-small cell lung cancer 31317683
ENSG00000115866 DARS1 thyroid cancer 31841198
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000115866 DARS1 PAAD 0.0011 high
ENSG00000115866 DARS1 UCEC 0.042 high
ENSG00000115866 DARS1 THCA 0.0049 high
ENSG00000115866 DARS1 ACC 0.011 high
ENSG00000115866 DARS1 HNSC 0.014 high
ENSG00000115866 DARS1 KICH 0.0019 high
ENSG00000115866 DARS1 LUAD 0.00038 high
ENSG00000115866 DARS1 COAD 0.041 high
ENSG00000115866 DARS1 UCS 0.013 high
ENSG00000115866 DARS1 OV 0.0079 low
ENSG00000115866 DARS1 DLBC 0.012 high
ENSG00000115866 DARS1 BLCA 0.035 low
ENSG00000115866 DARS1 LAML 0.044 low
ENSG00000115866 DARS1 GBM 0.026 low
ENSG00000115866 DARS1 SKCM 0.015 low
ENSG00000115866 DARS1 CESC 0.0074 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000115866 DARS1 DLBC Del 0.821169 0.130820 0.488262 0.145833
ENSG00000115866 DARS1 PRAD Del 15.463987 0.180442 0.527293 0.178862