Ensembl ID ENSG00000115421 Gene ID 64895 Accession 14982
Gene Symbol PAPOLG Alias NA Full Name poly(A) polymerase gamma
Position 2 : 60756266 - 60802086 Length 45821 bases Strand Plus strand
Status Confidence Main interacting RNAsmRNARBP type Canonical_RBPs
Summary This gene encodes a member of the poly(A) polymerase family which catalyzes template-independent extension of the 3' end of a DNA/RNA strand. This enzyme shares 60% identity to the well characterized poly(A) polymerase II (PAPII) at the amino acid level. These two enzymes have similar organization of structural and functional domains. This enzyme is exclusively localized in the nucleus and exhibits both nonspecific and CPSF (cleavage and polyadenylation specificity factor)/AAUAAA-dependent polyadenylation activity. This gene is located on chromosome 2 in contrast to the PAPII gene, which is located on chromosome 14. [provided by RefSeq, Jul 2008]

ENSG00000115421 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000115421 PAPOLG 0.68 1.49e-15 LUSC
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000115421 PAPOLG tumors 11463842
ENSG00000115421 PAPOLG tumor 12359760
ENSG00000115421 PAPOLG tumor 12718761
ENSG00000115421 PAPOLG tumor 23551967
ENSG00000115421 PAPOLG bladder cancer 2408158
ENSG00000115421 PAPOLG tumor 31410080
ENSG00000115421 PAPOLG breast cancer 7542253
ENSG00000115421 PAPOLG tumor 8306346
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000115421 PAPOLG MESO 0.029 high
ENSG00000115421 PAPOLG UCEC 0.0057 high
ENSG00000115421 PAPOLG THCA 0.023 low
ENSG00000115421 PAPOLG ACC 0.00088 high
ENSG00000115421 PAPOLG LGG 0.0013 high
ENSG00000115421 PAPOLG READ 0.047 low
ENSG00000115421 PAPOLG KIRP 0.00078 high
ENSG00000115421 PAPOLG KICH 0.0049 high
ENSG00000115421 PAPOLG LUAD 0.024 low
ENSG00000115421 PAPOLG THYM 0.016 low
ENSG00000115421 PAPOLG ESCA 0.039 high
ENSG00000115421 PAPOLG DLBC 0.029 high
ENSG00000115421 PAPOLG KIRC 0.01 low
ENSG00000115421 PAPOLG TGCT 0.019 high
ENSG00000115421 PAPOLG BLCA 0.049 low
ENSG00000115421 PAPOLG LAML 0.022 low
ENSG00000115421 PAPOLG GBM 0.048 low
ENSG00000115421 PAPOLG SKCM 0.006 low
ENSG00000115421 PAPOLG CESC 0.037 high
ENSG00000115421 PAPOLG LIHC 0.00095 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000115421 PAPOLG LUSC Amp 15.187760 0.479472 0.711541 0.546906
ENSG00000115421 PAPOLG DLBC Amp 13.734164 1.079357 1.534000 0.312500