Ensembl ID ENSG00000115306 Gene ID 6711 Accession 11275
Gene Symbol SPTBN1 Alias ELF;SPTB2;DDISBA;HEL102;betaSpII Full Name spectrin beta, non-erythrocytic 1
Position 2 : 54456317 - 54671446 Length 215130 bases Strand Plus strand
Status Confidence Main interacting RNAsN.A.RBP type Non-canonical_RBPs
Summary Spectrin is an actin crosslinking and molecular scaffold protein that links the plasma membrane to the actin cytoskeleton, and functions in the determination of cell shape, arrangement of transmembrane proteins, and organization of organelles. It is composed of two antiparallel dimers of alpha- and beta- subunits. This gene is one member of a family of beta-spectrin genes. The encoded protein contains an N-terminal actin-binding domain, and 17 spectrin repeats which are involved in dimer formation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

ENSG00000115306 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000115306 SPTBN1 -2.0 1.21e-204 BRCA
ENSG00000115306 SPTBN1 -2.1 6.77e-143 LUSC
ENSG00000115306 SPTBN1 -0.7 7.00e-15 PRAD
ENSG00000115306 SPTBN1 -0.9 5.09e-14 UCEC
ENSG00000115306 SPTBN1 -1.7 7.60e-80 LUAD
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000115306 SPTBN1 tumors 19116033
ENSG00000115306 SPTBN1 tumor 20739274
ENSG00000115306 SPTBN1 pancreatic cancer 20886430
ENSG00000115306 SPTBN1 tumor 25307947
ENSG00000115306 SPTBN1 cancer 25354783
ENSG00000115306 SPTBN1 pancreatic cancer 25912578
ENSG00000115306 SPTBN1 tumor 25927284
ENSG00000115306 SPTBN1 liver cancer 26631547
ENSG00000115306 SPTBN1 cancers 26784546
ENSG00000115306 SPTBN1 liver cancer 27248179
ENSG00000115306 SPTBN1 tumor 30795634
ENSG00000115306 SPTBN1 cancer 31186638
ENSG00000115306 SPTBN1 cancer 31206681
ENSG00000115306 SPTBN1 tumour 9537418
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000115306 SPTBN1 MESO 0.015 high
ENSG00000115306 SPTBN1 CHOL 0.038 low
ENSG00000115306 SPTBN1 UVM 0.0042 high
ENSG00000115306 SPTBN1 PAAD 0.015 high
ENSG00000115306 SPTBN1 THCA 0.00022 high
ENSG00000115306 SPTBN1 ACC 0.0011 high
ENSG00000115306 SPTBN1 READ 0.00089 low
ENSG00000115306 SPTBN1 KIRP 0.0063 high
ENSG00000115306 SPTBN1 THYM 0.013 low
ENSG00000115306 SPTBN1 BLCA 0.007 high
ENSG00000115306 SPTBN1 LAML 0.038 low
ENSG00000115306 SPTBN1 GBM 0.017 low
ENSG00000115306 SPTBN1 CESC 0.0079 high
ENSG00000115306 SPTBN1 LIHC 0.016 low
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000115306 SPTBN1 LUSC Amp 2.244824 0.242238 0.547747 0.530938