Ensembl ID ENSG00000115267 Gene ID 64135 Accession 18873
Gene Symbol IFIH1 Alias AGS7;Hlcd;MDA5;IMD95;MDA-5;RLR-2;IDDM19;SGMRT1 Full Name interferon induced with helicase C domain 1
Position 2 : 162267074 - 162318684 Length 51611 bases Strand Minus strand
Status Confidence Main interacting RNAsncRNARBP type Canonical_RBPs
Summary IFIH1 encodes MDA5 which is an intracellular sensor of viral RNA that triggers the innate immune response. Sensing RNA length and secondary structure, MDA5 binds dsRNA oligonucleotides with a modified DExD/H-box helicase core and a C-terminal domain, thus leading to a proinflammatory response that includes interferons. It has been shown that Coronaviruses (CoVs) as well as various other virus families, are capable of evading the MDA5-dependent interferon response, thus impeding the activation of the innate immune response to infection. MDA5 has also been shown to play an important role in enhancing natural killer cell function in malaria infection. In addition to its protective role in antiviral responses, MDA5 has been implicated in autoimmune and autoinflammatory diseases such as type 1 diabetes, systemic lupus erythematosus, and Aicardi-Goutieres syndrome[provided by RefSeq, Jul 2020]

ENSG00000115267 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000115267 IFIH1 1.29 2.00e-13 HNSC
ENSG00000115267 IFIH1 0.89 1.06e-17 BRCA
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000115267 IFIH1 prostate cancer 16804532
ENSG00000115267 IFIH1 tumors 18155685
ENSG00000115267 IFIH1 tumor 18199340
ENSG00000115267 IFIH1 tumour 18559930
ENSG00000115267 IFIH1 tumor 19620789
ENSG00000115267 IFIH1 CNS tumor 19769732
ENSG00000115267 IFIH1 cancer 21728171
ENSG00000115267 IFIH1 tumors 22027694
ENSG00000115267 IFIH1 tumor 22720240
ENSG00000115267 IFIH1 tumor 22934250
ENSG00000115267 IFIH1 breast cancer 23370279
ENSG00000115267 IFIH1 cancer 23390110
ENSG00000115267 IFIH1 cancer 23414438
ENSG00000115267 IFIH1 HNSCC 23484008
ENSG00000115267 IFIH1 cancer 23568993
ENSG00000115267 IFIH1 tumor 24155891
ENSG00000115267 IFIH1 cancer 24237222
ENSG00000115267 IFIH1 tumor 24573197
ENSG00000115267 IFIH1 cancer 24670134
ENSG00000115267 IFIH1 Cancer 24741583
ENSG00000115267 IFIH1 tumour 24773544
ENSG00000115267 IFIH1 breast cancer 24937182
ENSG00000115267 IFIH1 tumor 25012502
ENSG00000115267 IFIH1 breast cancer 25227113
ENSG00000115267 IFIH1 tumor 25866783
ENSG00000115267 IFIH1 tumor 25898986
ENSG00000115267 IFIH1 cancer 25950488
ENSG00000115267 IFIH1 thyroid cancer 25958950
ENSG00000115267 IFIH1 tumors 26021444
ENSG00000115267 IFIH1 tumor 26208481
ENSG00000115267 IFIH1 tumor 26317465
ENSG00000115267 IFIH1 tumor 26504669
ENSG00000115267 IFIH1 Cancer 26893477
ENSG00000115267 IFIH1 tumors 27034163
ENSG00000115267 IFIH1 breast cancer 27077807
ENSG00000115267 IFIH1 cancer 27141349
ENSG00000115267 IFIH1 colorectal cancer 27307795
ENSG00000115267 IFIH1 cancer 27407235
ENSG00000115267 IFIH1 cancer 28198709
ENSG00000115267 IFIH1 tumor 28216575
ENSG00000115267 IFIH1 breast tumors 28533483
ENSG00000115267 IFIH1 GBM 28667284
ENSG00000115267 IFIH1 cancer 28917654
ENSG00000115267 IFIH1 colon cancer 28940253
ENSG00000115267 IFIH1 cancer 29032202
ENSG00000115267 IFIH1 tumor 29383037
ENSG00000115267 IFIH1 lung cancers 29512705
ENSG00000115267 IFIH1 cancer 29686682
ENSG00000115267 IFIH1 lung cancer 29691392
ENSG00000115267 IFIH1 tumor 29696308
ENSG00000115267 IFIH1 squamous cell cancer 29950349
ENSG00000115267 IFIH1 Cancer 29997212
ENSG00000115267 IFIH1 cancer 30140893
ENSG00000115267 IFIH1 tumor 30181782
ENSG00000115267 IFIH1 cancer 30201512
ENSG00000115267 IFIH1 cancer 30344746
ENSG00000115267 IFIH1 tumour 30559380
ENSG00000115267 IFIH1 tumor 30559422
ENSG00000115267 IFIH1 cancer 30575730
ENSG00000115267 IFIH1 ovarian cancer 30613350
ENSG00000115267 IFIH1 cancer 30861413
ENSG00000115267 IFIH1 cancer 30915368
ENSG00000115267 IFIH1 cancer 31988456
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000115267 IFIH1 MESO 0.0032 low
ENSG00000115267 IFIH1 CHOL 0.037 low
ENSG00000115267 IFIH1 PAAD 0.001 high
ENSG00000115267 IFIH1 UCEC 0.0032 high
ENSG00000115267 IFIH1 THCA 0.048 low
ENSG00000115267 IFIH1 READ 0.011 low
ENSG00000115267 IFIH1 KIRP 0.036 high
ENSG00000115267 IFIH1 KICH 7e-04 high
ENSG00000115267 IFIH1 LUAD 0.0023 high
ENSG00000115267 IFIH1 OV 0.028 low
ENSG00000115267 IFIH1 BLCA 0.029 low
ENSG00000115267 IFIH1 CESC 0.044 high
ENSG00000115267 IFIH1 LIHC 0.036 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000115267 IFIH1 DLBC Del 1.182121 0.151120 0.487676 0.166667
ENSG00000115267 IFIH1 PRAD Del 2.151735 0.089781 0.445943 0.113821