Ensembl ID ENSG00000114686 Gene ID 11222 Accession 10379
Gene Symbol MRPL3 Alias MRL3;uL3m;RPML3;COXPD9 Full Name mitochondrial ribosomal protein L3
Position 3 : 131462212 - 131502983 Length 40772 bases Strand Minus strand
Status Confidence Main interacting RNAsrRNARBP type Canonical_RBPs
Summary Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein that belongs to the L3P ribosomal protein family. A pseudogene corresponding to this gene is found on chromosome 13q. [provided by RefSeq, Jul 2008]

ENSG00000114686 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000114686 MRPL3 0.68 4.14e-48 BRCA
ENSG00000114686 MRPL3 0.80 1.28e-30 COAD
ENSG00000114686 MRPL3 0.84 5.96e-11 KICH
ENSG00000114686 MRPL3 1.66 6.27e-83 LUSC
ENSG00000114686 MRPL3 0.67 3.88e-15 UCEC
ENSG00000114686 MRPL3 1.01 2.44e-42 LUAD
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000114686 MRPL3 tumors 18851746
ENSG00000114686 MRPL3 tumor 24223926
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000114686 MRPL3 MESO 0.00096 high
ENSG00000114686 MRPL3 UVM 0.014 low
ENSG00000114686 MRPL3 UCEC 0.0012 high
ENSG00000114686 MRPL3 LGG 0.0013 low
ENSG00000114686 MRPL3 LUSC 0.025 low
ENSG00000114686 MRPL3 HNSC 0.012 high
ENSG00000114686 MRPL3 READ 0.013 low
ENSG00000114686 MRPL3 KIRP 0.013 high
ENSG00000114686 MRPL3 KICH 0.039 high
ENSG00000114686 MRPL3 LUAD 0.017 high
ENSG00000114686 MRPL3 PCPG 0.039 high
ENSG00000114686 MRPL3 BRCA 0.035 high
ENSG00000114686 MRPL3 OV 0.00029 low
ENSG00000114686 MRPL3 GBM 0.04 low
ENSG00000114686 MRPL3 SKCM 0.0014 low
ENSG00000114686 MRPL3 CESC 0.027 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000114686 MRPL3 LUSC Amp 0.871041 0.199584 0.697357 0.726547
ENSG00000114686 MRPL3 CESC Amp 0.827922 0.133039 0.862073 0.644068
ENSG00000114686 MRPL3 PRAD Amp 0.840292 0.047999 0.403955 0.140244