Ensembl ID ENSG00000113648 Gene ID 9555 Accession 4740
Gene Symbol MACROH2A1 Alias H2A.y;H2A/y;H2AFY;mH2A1;H2AF12M;MACROH2A1.1;macroH2A1.2 Full Name macroH2A.1 histone
Position 5 : 135334381 - 135399887 Length 65507 bases Strand Minus strand
Status Confidence Main interacting RNAsN.A.RBP type Non-canonical_RBPs
Summary Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a replication-independent histone that is a member of the histone H2A family. It replaces conventional H2A histones in a subset of nucleosomes where it represses transcription and participates in stable X chromosome inactivation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2015]

ENSG00000113648 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000113648 1.08 1.02e-139 BRCA
ENSG00000113648 0.44 2.18e-13 COAD
ENSG00000113648 0.63 5.79e-18 LIHC
ENSG00000113648 1.08 4.51e-65 UCEC
ENSG00000113648 1.15 9.87e-18 CHOL
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000113648 lung cancer 19648962
ENSG00000113648 cancer 22589551
ENSG00000113648 DLBCL 23828858
ENSG00000113648 breast cancer 24911873
ENSG00000113648 cancer 25003966
ENSG00000113648 pituitary tumor 25188299
ENSG00000113648 cancer 25510493
ENSG00000113648 breast cancer 25818643
ENSG00000113648 bladder cancer 26028027
ENSG00000113648 cancer 26658220
ENSG00000113648 cancer 27965283
ENSG00000113648 prostate cancer 28131897
ENSG00000113648 prostate cancer 29925860
ENSG00000113648 breast cancer 31248103
ENSG00000113648 GBM 31488827
ENSG00000113648 cancer 31903159
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000113648 MESO 0.028 high
ENSG00000113648 UVM 0.0023 high
ENSG00000113648 UCEC 0.028 high
ENSG00000113648 READ 0.026 low
ENSG00000113648 LUAD 0.024 high
ENSG00000113648 PCPG 0.04 high
ENSG00000113648 THYM 0.0045 low
ENSG00000113648 COAD 0.007 low
ENSG00000113648 ESCA 0.045 high
ENSG00000113648 OV 0.0066 low
ENSG00000113648 DLBC 0.00028 low
ENSG00000113648 KIRC 0.001 high
ENSG00000113648 LAML 0.0021 low
ENSG00000113648 SKCM 0.016 high
ENSG00000113648 CESC 0.049 low
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000113648 LAML Del 6.829700 0.095795 0.799843 0.089005
ENSG00000113648 LUAD Del 1.726987 0.064413 0.338183 0.401163
ENSG00000113648 LGG Del 0.731332 0.039254 0.384005 0.087719
ENSG00000113648 ACC Amp 0.765694 0.253036 1.229454 0.666667
ENSG00000113648 SKCM Del 3.087058 0.100890 0.487966 0.318801
ENSG00000113648 STAD Del 1.693839 0.074632 0.385251 0.326531
ENSG00000113648 KIRC Amp 45.433636 0.270302 0.535393 0.594697