Ensembl ID ENSG00000113522 Gene ID 10111 Accession 9816
Gene Symbol RAD50 Alias NBSLD;RAD502;hRad50 Full Name RAD50 double strand break repair protein
Position 5 : 132556019 - 132646349 Length 90331 bases Strand Plus strand
Status Confidence Main interacting RNAsN.A.RBP type Non-canonical_RBPs
Summary The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Rad50, a protein involved in DNA double-strand break repair. This protein forms a complex with MRE11 and NBS1. The protein complex binds to DNA and displays numerous enzymatic activities that are required for nonhomologous joining of DNA ends. This protein, cooperating with its partners, is important for DNA double-strand break repair, cell cycle checkpoint activation, telomere maintenance, and meiotic recombination. Knockout studies of the mouse homolog suggest this gene is essential for cell growth and viability. Mutations in this gene are the cause of Nijmegen breakage syndrome-like disorder.[provided by RefSeq, Apr 2010]

ENSG00000113522 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000113522 cancer 10362365
ENSG00000113522 tumor 10783165
ENSG00000113522 tumor 10918303
ENSG00000113522 tumors 11196187
ENSG00000113522 tumor 11373271
ENSG00000113522 colorectal cancers 11429044
ENSG00000113522 tumor 11754637
ENSG00000113522 tumours 11850399
ENSG00000113522 colorectal cancers 11888892
ENSG00000113522 tumor 12709261
ENSG00000113522 tumor 12957814
ENSG00000113522 tumor 14550546
ENSG00000113522 tumor 14716681
ENSG00000113522 cancer 15048091
ENSG00000113522 cancer 15964827
ENSG00000113522 tumors 16025146
ENSG00000113522 prostate tumors 16207477
ENSG00000113522 breast tumors 16234517
ENSG00000113522 tumours 16288216
ENSG00000113522 familial breast cancer 16385572
ENSG00000113522 cancer 16394135
ENSG00000113522 breast cancer 16474176
ENSG00000113522 tumor 16570289
ENSG00000113522 cancer 16752129
ENSG00000113522 cancer 16757656
ENSG00000113522 AML 16914901
ENSG00000113522 tumours 17384679
ENSG00000113522 tumours 17534377
ENSG00000113522 Colorectal Cancers 18219098
ENSG00000113522 pancreatic tumor 18281469
ENSG00000113522 tumor 18606567
ENSG00000113522 bladder cancer 18638378
ENSG00000113522 colorectal cancer 18830935
ENSG00000113522 breast cancer 19092773
ENSG00000113522 breast cancer 19383352
ENSG00000113522 tumor 19487811
ENSG00000113522 ovarian cancer 19584272
ENSG00000113522 cancer 20015360
ENSG00000113522 tumours 20148879
ENSG00000113522 tumor 20478923
ENSG00000113522 cancer 20679231
ENSG00000113522 tumor 20843819
ENSG00000113522 breast cancer 21336636
ENSG00000113522 ovarian cancer 21356067
ENSG00000113522 Breast cancer 21599985
ENSG00000113522 prostate cancer 21777411
ENSG00000113522 breast cancer 21799032
ENSG00000113522 hereditary breast cancer 21811815
ENSG00000113522 tumors 22048815
ENSG00000113522 cancer 22743550
ENSG00000113522 gastric cancer 23028900
ENSG00000113522 tumor 23063122
ENSG00000113522 cancer 23181716
ENSG00000113522 breast cancer 23318652
ENSG00000113522 breast cancer 23357080
ENSG00000113522 prostate cancer 23361058
ENSG00000113522 breast cancer 23555315
ENSG00000113522 breast cancer 23761956
ENSG00000113522 pancreatic cancer 23954013
ENSG00000113522 breast cancer 24025454
ENSG00000113522 tumors 24044516
ENSG00000113522 head and neck cancers 24079363
ENSG00000113522 AML 24093751
ENSG00000113522 tumor 24324792
ENSG00000113522 Cancer 24448499
ENSG00000113522 cancer 24550935
ENSG00000113522 cancer 24556366
ENSG00000113522 tumour 24625413
ENSG00000113522 breast cancer 24642965
ENSG00000113522 breast cancer 24884479
ENSG00000113522 Breast Cancer 24894818
ENSG00000113522 endometrial cancers 24927325
ENSG00000113522 cancer 24934408
ENSG00000113522 small-cell cancer 25185187
ENSG00000113522 breast cancer 25528023
ENSG00000113522 tumor 25605214
ENSG00000113522 breast cancer 25824734
ENSG00000113522 tumors 25918678
ENSG00000113522 breast cancer 25927356
ENSG00000113522 ovarian cancer 25964535
ENSG00000113522 cancer 26438152
ENSG00000113522 breast cancer 26534844
ENSG00000113522 prostate cancer 26628996
ENSG00000113522 breast cancer 26787654
ENSG00000113522 tumor 26951044
ENSG00000113522 ovarian cancer 27016230
ENSG00000113522 ovarian cancer 27144062
ENSG00000113522 breast cancer 27318168
ENSG00000113522 cancer 27738139
ENSG00000113522 breast cancer 27775439
ENSG00000113522 hereditary breast cancer 27783279
ENSG00000113522 Gastric Cancer 27798884
ENSG00000113522 endometrial cancer 27997699
ENSG00000113522 tumor 28053956
ENSG00000113522 cancer 28059167
ENSG00000113522 epithelial ovarian cancer 28073364
ENSG00000113522 tumors 28092266
ENSG00000113522 GBMs 28094268
ENSG00000113522 tumors 28191281
ENSG00000113522 breast cancer 28241424
ENSG00000113522 tumor 28376765
ENSG00000113522 breast cancer 28419251
ENSG00000113522 tumor 28424414
ENSG00000113522 ovarian cancer 28559769
ENSG00000113522 breast cancer 28649662
ENSG00000113522 Tumor 28679765
ENSG00000113522 cancer 28819025
ENSG00000113522 ovarian cancer 28888541
ENSG00000113522 breast cancer 28891274
ENSG00000113522 Non-small Cell Lung Cancer 29030353
ENSG00000113522 GBM 29145449
ENSG00000113522 oral cancer 29165875
ENSG00000113522 Rectal Cancer 29189711
ENSG00000113522 breast cancer 29271107
ENSG00000113522 colorectal cancer 29322791
ENSG00000113522 breast cancer 29368209
ENSG00000113522 breast cancer 29566657
ENSG00000113522 breast cancer 29726012
ENSG00000113522 breast cancer 29785153
ENSG00000113522 Breast cancer 29867559
ENSG00000113522 breast cancer 29874127
ENSG00000113522 hereditary breast and ovarian cancer 29879995
ENSG00000113522 ovarian cancer 29928469
ENSG00000113522 cancers 29958926
ENSG00000113522 tumors 30038706
ENSG00000113522 cancer 30093976
ENSG00000113522 tumors 30104415
ENSG00000113522 tumor 30176843
ENSG00000113522 pancreatic cancer 30201439
ENSG00000113522 tumors 30234181
ENSG00000113522 Cancer 30283497
ENSG00000113522 cancer 30345029
ENSG00000113522 tumor 30376358
ENSG00000113522 tumour 30385821
ENSG00000113522 AML 30480765
ENSG00000113522 cancer 30755392
ENSG00000113522 Colorectal Cancer 30769804
ENSG00000113522 cancer 30788456
ENSG00000113522 breast cancer 30799775
ENSG00000113522 breast cancer 30967997
ENSG00000113522 colorectal cancer 31060309
ENSG00000113522 Cancer 31273614
ENSG00000113522 tumor 31488179
ENSG00000113522 cancer 31767017
ENSG00000113522 breast cancer 31872854
ENSG00000113522 cancer 31937788
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000113522 MESO 0.00033 low
ENSG00000113522 SARC 0.019 low
ENSG00000113522 PAAD 0.0032 high
ENSG00000113522 UCEC 0.0011 high
ENSG00000113522 THCA 0.027 high
ENSG00000113522 ACC 0.017 low
ENSG00000113522 LGG 0.0079 high
ENSG00000113522 LUSC 0.04 high
ENSG00000113522 HNSC 0.048 high
ENSG00000113522 READ 0.011 low
ENSG00000113522 KICH 0.0046 high
ENSG00000113522 PCPG 0.044 low
ENSG00000113522 BRCA 0.002 high
ENSG00000113522 ESCA 0.031 high
ENSG00000113522 PRAD 0.011 low
ENSG00000113522 LAML 0.0026 low
ENSG00000113522 GBM 0.01 high
ENSG00000113522 LIHC 0.0021 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000113522 LAML Del 6.887040 0.098062 0.799843 0.089005
ENSG00000113522 LUAD Del 2.554155 0.072806 0.347112 0.403101
ENSG00000113522 LGG Del 0.930144 0.041575 0.381550 0.087719
ENSG00000113522 ACC Amp 1.248228 0.334625 1.279159 0.666667
ENSG00000113522 COAD Del 1.064782 0.046571 0.390908 0.223947
ENSG00000113522 SKCM Del 2.500347 0.093515 0.487701 0.326975
ENSG00000113522 HNSC Del 0.809460 0.055584 0.383148 0.396552
ENSG00000113522 STAD Del 3.099256 0.090835 0.389371 0.342404
ENSG00000113522 KIRC Amp 45.017225 0.268776 0.537222 0.592803
ENSG00000113522 OV Del 1.241422 0.187360 0.559168 0.466321