Ensembl ID ENSG00000112992 Gene ID 23530 Accession 7863
Gene Symbol NNT Alias GCCD4 Full Name nicotinamide nucleotide transhydrogenase
Position 5 : 43602692 - 43707405 Length 104714 bases Strand Plus strand
Status Confidence Main interacting RNAsN.A.RBP type Non-canonical_RBPs
Summary This gene encodes an integral protein of the inner mitochondrial membrane. The enzyme couples hydride transfer between NAD(H) and NADP(+) to proton translocation across the inner mitochondrial membrane. Under most physiological conditions, the enzyme uses energy from the mitochondrial proton gradient to produce high concentrations of NADPH. The resulting NADPH is used for biosynthesis and in free radical detoxification. [provided by RefSeq, Sep 2016]

ENSG00000112992 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000112992 -1.2 3.46e-25 KIRC
ENSG00000112992 -1.4 3.42e-25 HNSC
ENSG00000112992 -0.6 6.86e-13 COAD
ENSG00000112992 1.76 7.96e-25 KICH
ENSG00000112992 -0.8 5.05e-21 PRAD
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000112992 breast cancer 10571703
ENSG00000112992 tumours 16797226
ENSG00000112992 tumour 18640781
ENSG00000112992 gastric cancer 20479409
ENSG00000112992 cancer 20488911
ENSG00000112992 cancer 21483701
ENSG00000112992 cancer 21882037
ENSG00000112992 tumor 2511986
ENSG00000112992 cancer 25742020
ENSG00000112992 tumors 25806335
ENSG00000112992 adrenal rest tumor 25879317
ENSG00000112992 cancer 27459240
ENSG00000112992 tumor 27826771
ENSG00000112992 colorectal cancer 27966450
ENSG00000112992 tumour 28176964
ENSG00000112992 cancer 28478381
ENSG00000112992 tumor 28604662
ENSG00000112992 cervical cancer 28628975
ENSG00000112992 cancer 28649560
ENSG00000112992 tumor 29179477
ENSG00000112992 Tumor 29518771
ENSG00000112992 breast cancer 29710510
ENSG00000112992 ovarian cancer 29805655
ENSG00000112992 breast cancer 29849714
ENSG00000112992 lung cancer 29857296
ENSG00000112992 gastric cancer 30006956
ENSG00000112992 tumor 30059901
ENSG00000112992 non-small cell lung cancer 30070323
ENSG00000112992 gastric cancer 30324628
ENSG00000112992 tumor 30489194
ENSG00000112992 cancer 30600642
ENSG00000112992 cancer 30787076
ENSG00000112992 cancer 31057428
ENSG00000112992 tumor 31210440
ENSG00000112992 cancer 31288436
ENSG00000112992 gastric cancer 31309731
ENSG00000112992 tumor 31616187
ENSG00000112992 bladder cancer 31782983
ENSG00000112992 bladder cancer 31848324
ENSG00000112992 non-small cell lung cancer 31923353
ENSG00000112992 lung cancer 31957837
ENSG00000112992 cancer 31984870
ENSG00000112992 tumors 4393283
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000112992 MESO 0.041 low
ENSG00000112992 STAD 0.037 low
ENSG00000112992 UVM 0.015 high
ENSG00000112992 UCEC 0.001 high
ENSG00000112992 THCA 0.038 high
ENSG00000112992 ACC 0.012 low
ENSG00000112992 LGG 0.018 high
ENSG00000112992 READ 0.0088 low
ENSG00000112992 KIRP 0.0052 low
ENSG00000112992 LUAD 0.0011 low
ENSG00000112992 PCPG 0.0016 high
ENSG00000112992 THYM 0.026 high
ENSG00000112992 BRCA 0.018 high
ENSG00000112992 OV 0.026 low
ENSG00000112992 BLCA 0.037 low
ENSG00000112992 GBM 0.021 low
ENSG00000112992 CESC 0.048 low
ENSG00000112992 LIHC 0.02 low
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000112992 LUSC Amp 7.839311 0.360938 0.847882 0.724551
ENSG00000112992 LUAD Amp 6.427111 0.225714 0.691590 0.573643
ENSG00000112992 COAD Amp 0.973775 0.073132 0.550401 0.188470
ENSG00000112992 HNSC Amp 1.068346 0.125777 0.715754 0.396552
ENSG00000112992 BLCA Amp 0.649647 0.161258 0.752548 0.463235
ENSG00000112992 STAD Amp 3.635035 0.208601 0.776450 0.281179