Ensembl ID ENSG00000112855 Gene ID 23438 Accession 4817
Gene Symbol HARS2 Alias HO3;HARSL;HARSR;HisRS;PRLTS2 Full Name histidyl-tRNA synthetase 2, mitochondrial
Position 5 : 140691430 - 140699305 Length 7876 bases Strand Plus strand
Status Confidence Main interacting RNAstRNARBP type Canonical_RBPs
Summary Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. The protein encoded by this gene is an enzyme belonging to the class II family of aminoacyl-tRNA synthetases. Functioning in the synthesis of histidyl-transfer RNA, the enzyme plays an accessory role in the regulation of protein biosynthesis. The gene is located in a head-to-head orientation with HARS on chromosome five, where the homologous genes likely share a bidirectional promoter. Mutations in this gene are associated with the pathogenesis of Perrault syndrome, which involves ovarian dysgenesis and sensorineural hearing loss. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]

ENSG00000112855 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000112855 HARS2 0.33 1.80e-16 BRCA
ENSG00000112855 HARS2 0.52 1.56e-11 KICH
ENSG00000112855 HARS2 0.57 1.85e-17 LIHC
ENSG00000112855 HARS2 0.46 2.89e-16 LUAD
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000112855 HARS2 tumor 29670092
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000112855 HARS2 MESO 0.022 low
ENSG00000112855 HARS2 SARC 0.036 low
ENSG00000112855 HARS2 UVM 0.025 high
ENSG00000112855 HARS2 UCEC 0.015 low
ENSG00000112855 HARS2 ACC 0.0034 low
ENSG00000112855 HARS2 HNSC 0.0077 high
ENSG00000112855 HARS2 READ 0.0073 low
ENSG00000112855 HARS2 KIRP 0.00036 low
ENSG00000112855 HARS2 LUAD 0.0095 high
ENSG00000112855 HARS2 PCPG 0.019 high
ENSG00000112855 HARS2 THYM 0.012 high
ENSG00000112855 HARS2 BRCA 0.00087 high
ENSG00000112855 HARS2 COAD 0.0077 low
ENSG00000112855 HARS2 UCS 0.024 high
ENSG00000112855 HARS2 ESCA 0.039 high
ENSG00000112855 HARS2 OV 0.011 high
ENSG00000112855 HARS2 PRAD 0.019 high
ENSG00000112855 HARS2 BLCA 0.0063 low
ENSG00000112855 HARS2 GBM 0.035 high
ENSG00000112855 HARS2 SKCM 0.019 high
ENSG00000112855 HARS2 CESC 0.022 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000112855 HARS2 LAML Del 6.887040 0.098062 0.800690 0.089005
ENSG00000112855 HARS2 LGG Del 1.569337 0.048329 0.400463 0.091618
ENSG00000112855 HARS2 ACC Amp 0.754856 0.252199 1.227828 0.666667
ENSG00000112855 HARS2 SKCM Del 6.099343 0.133930 0.495355 0.337875
ENSG00000112855 HARS2 KIRC Amp 51.061677 0.292110 0.543534 0.609848