Ensembl ID ENSG00000112118 Gene ID 4172 Accession 6945
Gene Symbol MCM3 Alias HCC5;P1.h;RLFB;P1-MCM3 Full Name minichromosome maintenance complex component 3
Position 6 : 52264014 - 52284881 Length 20868 bases Strand Minus strand
Status Confidence Main interacting RNAsN.A.RBP type Non-canonical_RBPs
Summary The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein is a subunit of the protein complex that consists of MCM2-7. It has been shown to interact directly with MCM5/CDC46. This protein also interacts with and is acetylated by MCM3AP, a chromatin-associated acetyltransferase. The acetylation of this protein inhibits the initiation of DNA replication and cell cycle progression. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2018]

ENSG00000112118 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000112118 0.80 9.72e-16 HNSC
ENSG00000112118 0.89 3.19e-42 BRCA
ENSG00000112118 1.04 7.21e-39 COAD
ENSG00000112118 1.33 3.23e-42 LUSC
ENSG00000112118 1.52 2.42e-37 LIHC
ENSG00000112118 1.01 1.84e-17 STAD
ENSG00000112118 0.77 3.08e-12 UCEC
ENSG00000112118 1.96 5.80e-28 CHOL
ENSG00000112118 0.89 7.64e-23 LUAD
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000112118 tumour 11745678
ENSG00000112118 cancers 15623617
ENSG00000112118 brain tumors 15671553
ENSG00000112118 tumor 17129373
ENSG00000112118 tumor 19389522
ENSG00000112118 tumor 19818763
ENSG00000112118 tumor 20177751
ENSG00000112118 tumor 20661220
ENSG00000112118 cancers 20838603
ENSG00000112118 cancer 21479452
ENSG00000112118 ovarian cancer 21804916
ENSG00000112118 cancer 22102875
ENSG00000112118 tumor 22699783
ENSG00000112118 tumours 22805320
ENSG00000112118 cancer 22838965
ENSG00000112118 tumour 23225429
ENSG00000112118 tumors 23874974
ENSG00000112118 malignant salivary gland tumors 23886132
ENSG00000112118 tumors 23982162
ENSG00000112118 cancer 24344040
ENSG00000112118 tumours 24386425
ENSG00000112118 tumor 25046975
ENSG00000112118 gastric cancer 25916094
ENSG00000112118 cancers 26046103
ENSG00000112118 kidney-cancer 26283601
ENSG00000112118 tumors 26790448
ENSG00000112118 tumors 26823641
ENSG00000112118 epithelial ovarian cancer 27147467
ENSG00000112118 tumor 27258565
ENSG00000112118 odontogenic tumors 27516012
ENSG00000112118 cancer 27703371
ENSG00000112118 prostate cancer 28424404
ENSG00000112118 tumor 28460433
ENSG00000112118 ovarian tumors 28493257
ENSG00000112118 breast cancer 29180339
ENSG00000112118 kidney cancer 29180899
ENSG00000112118 colon cancer 29534671
ENSG00000112118 cervical cancer 29719595
ENSG00000112118 esophageal cancer 29922071
ENSG00000112118 Cancer 30042207
ENSG00000112118 cancer 30042885
ENSG00000112118 tumors 30225187
ENSG00000112118 tumor 30233242
ENSG00000112118 Tumor 30363964
ENSG00000112118 Cancer 30413320
ENSG00000112118 tumor 31186514
ENSG00000112118 tumor 31208444
ENSG00000112118 cancers 31323040
ENSG00000112118 tumours 31461552
ENSG00000112118 ovarian cancer 31703725
ENSG00000112118 tumor 31737652
ENSG00000112118 tumor 31966536
ENSG00000112118 tumor 31980982
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000112118 MESO 0.033 high
ENSG00000112118 SARC 0.00056 high
ENSG00000112118 STAD 0.0078 low
ENSG00000112118 CHOL 0.032 high
ENSG00000112118 UVM 0.028 high
ENSG00000112118 PAAD 0.034 high
ENSG00000112118 UCEC 0.019 high
ENSG00000112118 LUSC 0.02 low
ENSG00000112118 HNSC 0.0042 low
ENSG00000112118 READ 0.044 low
ENSG00000112118 KIRP 0.0043 high
ENSG00000112118 LUAD 0.013 high
ENSG00000112118 PCPG 0.032 high
ENSG00000112118 THYM 4e-04 low
ENSG00000112118 COAD 0.046 low
ENSG00000112118 UCS 0.02 low
ENSG00000112118 OV 0.0022 low
ENSG00000112118 DLBC 0.002 low
ENSG00000112118 KIRC 0.038 low
ENSG00000112118 BLCA 0.0078 low
ENSG00000112118 LAML 5e-04 high
ENSG00000112118 CESC 0.00021 low
ENSG00000112118 LIHC 0.00027 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000112118 LUSC Amp 1.142379 0.209218 0.503519 0.321357
ENSG00000112118 ESCA Amp 1.492262 0.309956 0.582848 0.336957
ENSG00000112118 STAD Amp 2.172376 0.174388 0.517745 0.260771