Ensembl ID ENSG00000112081 Gene ID 6428 Accession 10785
Gene Symbol SRSF3 Alias SFRS3;SRp20 Full Name serine and arginine rich splicing factor 3
Position 6 : 36594353 - 36605600 Length 11248 bases Strand Plus strand
Status Confidence Main interacting RNAsmRNARBP type Canonical_RBPs
Summary The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. Two transcript variants, one protein-coding and the other non-coding, have been found for this gene. [provided by RefSeq, Sep 2010]

ENSG00000112081 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000112081 SRSF3 -0.9 7.37e-26 KICH
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000112081 SRSF3 breast cancer 20842223
ENSG00000112081 SRSF3 cancers 21179588
ENSG00000112081 SRSF3 AML 22722453
ENSG00000112081 SRSF3 tumor 22777358
ENSG00000112081 SRSF3 colon cancer 23503458
ENSG00000112081 SRSF3 cancer 23935626
ENSG00000112081 SRSF3 colon cancer 24284797
ENSG00000112081 SRSF3 tumor 24333670
ENSG00000112081 SRSF3 ovarian cancer 26282282
ENSG00000112081 SRSF3 breast cancer 26367347
ENSG00000112081 SRSF3 cancer 26416554
ENSG00000112081 SRSF3 cancers 26704980
ENSG00000112081 SRSF3 tumor 26773498
ENSG00000112081 SRSF3 breast tumors 26930004
ENSG00000112081 SRSF3 cancer 27282379
ENSG00000112081 SRSF3 cancers 27429590
ENSG00000112081 SRSF3 cancer 27983653
ENSG00000112081 SRSF3 tumor 27984373
ENSG00000112081 SRSF3 cancer 28039456
ENSG00000112081 SRSF3 cancer 28374191
ENSG00000112081 SRSF3 cancer 28624413
ENSG00000112081 SRSF3 colorectal cancer 29131639
ENSG00000112081 SRSF3 colorectal cancer 29138007
ENSG00000112081 SRSF3 cancer 29254178
ENSG00000112081 SRSF3 cancer 29288986
ENSG00000112081 SRSF3 cancer 29568365
ENSG00000112081 SRSF3 breast cancer 29581274
ENSG00000112081 SRSF3 cancer 29741478
ENSG00000112081 SRSF3 cancer 29857020
ENSG00000112081 SRSF3 Tumor 30279379
ENSG00000112081 SRSF3 cancer 30455716
ENSG00000112081 SRSF3 cancers 30463359
ENSG00000112081 SRSF3 cancer 30548479
ENSG00000112081 SRSF3 tumors 30637779
ENSG00000112081 SRSF3 cancer 30796096
ENSG00000112081 SRSF3 cancer 30835716
ENSG00000112081 SRSF3 breast cancer 30862604
ENSG00000112081 SRSF3 cancer 30881377
ENSG00000112081 SRSF3 breast cancer 31078657
ENSG00000112081 SRSF3 breast cancers 31138601
ENSG00000112081 SRSF3 tumor 31140152
ENSG00000112081 SRSF3 tumor 31145021
ENSG00000112081 SRSF3 tumor 31462429
ENSG00000112081 SRSF3 breast cancer 31515668
ENSG00000112081 SRSF3 breast cancer 31828152
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
ENSG00000112081 SRSF3 colorectal adenocarcinoma sequence_alteration 1.054% (12/1138) 1 entry
ENSG00000112081 SRSF3 diffuse gastric adenocarcinoma sequence_alteration 3.797% (3/79) 1 entry
ENSG00000112081 SRSF3 bladder transitional cell carcinoma missense_variant 1.46% (2/137) 1 entry
ENSG00000112081 SRSF3 hepatocellular carcinoma missense_variant 0.3333% (3/900) 1 entry
ENSG00000112081 SRSF3 skin melanoma missense_variant 0.5171% (5/967) 2 entries
ENSG00000112081 SRSF3 colon adenocarcinoma sequence_alteration 0.9695% (7/722) 2 entries
ENSG00000112081 SRSF3 colon adenocarcinoma missense_variant 0.9695% (7/722) 2 entries
ENSG00000112081 SRSF3 squamous cell lung carcinoma sequence_alteration 0.3937% (3/762) 1 entry
ENSG00000112081 SRSF3 brain glioblastoma sequence_alteration 0.216% (2/926) 1 entry
ENSG00000112081 SRSF3 prostate adenocarcinoma sequence_alteration 0.619% (9/1454) 1 entry
ENSG00000112081 SRSF3 colorectal adenocarcinoma missense_variant 1.054% (12/1138) 2 entries
ENSG00000112081 SRSF3 esophageal adenocarcinoma sequence_alteration 0.4566% (2/438) 1 entry
ENSG00000112081 SRSF3 adrenal cortex carcinoma stop_gained 0.6098% (1/164) 1 entry
ENSG00000112081 SRSF3 Endometrial Clear Cell Adenocarcinoma missense_variant 8.333% (1/12) 1 entry
ENSG00000112081 SRSF3 acute lymphoblastic leukemia frameshift_variant 0.3115% (1/321) 1 entry
ENSG00000112081 SRSF3 nasopharyngeal squamous cell carcinoma stop_gained 0.5988% (1/167) 1 entry
ENSG00000112081 SRSF3 cecum adenocarcinoma sequence_alteration 0.8% (1/125) 1 entry
ENSG00000112081 SRSF3 colon adenocarcinoma conservative_inframe_deletion 0.9695% (7/722) 1 entry
ENSG00000112081 SRSF3 alveolar rhabdomyosarcoma frameshift_variant 1.695% (1/59) 1 entry
ENSG00000112081 SRSF3 breast carcinoma sequence_alteration 0.1417% (2/1411) 1 entry
ENSG00000112081 SRSF3 prostate carcinoma sequence_alteration 0.4695% (2/426) 1 entry
ENSG00000112081 SRSF3 Pleural Epithelioid Mesothelioma sequence_alteration 1.064% (1/94) 1 entry
ENSG00000112081 SRSF3 Breast Diffuse Large B-Cell Lymphoma missense_variant 100.0% (1/1) 1 entry
ENSG00000112081 SRSF3 colorectal adenocarcinoma stop_gained 1.054% (12/1138) 1 entry
ENSG00000112081 SRSF3 pancreatic ductal adenocarcinoma missense_variant 0.4766% (6/1259) 1 entry
ENSG00000112081 SRSF3 prostate carcinoma frameshift_variant 0.4695% (2/426) 1 entry
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000112081 SRSF3 SARC 0.00079 high
ENSG00000112081 SRSF3 UVM 0.05 high
ENSG00000112081 SRSF3 PAAD 0.046 high
ENSG00000112081 SRSF3 LGG 0.044 high
ENSG00000112081 SRSF3 LUSC 0.0029 low
ENSG00000112081 SRSF3 HNSC 0.00096 high
ENSG00000112081 SRSF3 READ 0.0044 low
ENSG00000112081 SRSF3 KIRP 0.0031 high
ENSG00000112081 SRSF3 PCPG 0.0019 high
ENSG00000112081 SRSF3 THYM 0.0011 low
ENSG00000112081 SRSF3 COAD 0.0022 low
ENSG00000112081 SRSF3 UCS 0.00057 low
ENSG00000112081 SRSF3 ESCA 0.0028 high
ENSG00000112081 SRSF3 DLBC 0.0028 low
ENSG00000112081 SRSF3 KIRC 0.019 low
ENSG00000112081 SRSF3 TGCT 0.036 low
ENSG00000112081 SRSF3 BLCA 0.00046 low
ENSG00000112081 SRSF3 GBM 0.02 low
ENSG00000112081 SRSF3 SKCM 0.00018 low
ENSG00000112081 SRSF3 CESC 0.0019 low
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000112081 SRSF3 SKCM Amp 0.681254 0.118708 0.734986 0.498638
ENSG00000112081 SRSF3 UVM Amp 1.872709 0.238074 1.140112 0.537500
ENSG00000112081 SRSF3 OV Amp 0.696473 0.326594 0.687449 0.443869