Ensembl ID ENSG00000111716 Gene ID 3945 Accession 6541
Gene Symbol LDHB Alias LDH-B;LDH-H;LDHBD;TRG-5;HEL-S-281 Full Name lactate dehydrogenase B
Position 12 : 21635342 - 21757857 Length 122516 bases Strand Minus strand
Status Confidence Main interacting RNAsN.A.RBP type Non-canonical_RBPs
Summary This gene encodes the B subunit of lactate dehydrogenase enzyme, which catalyzes the interconversion of pyruvate and lactate with concomitant interconversion of NADH and NAD+ in a post-glycolysis process. Alternatively spliced transcript variants have been found for this gene. Recent studies have shown that a C-terminally extended isoform is produced by use of an alternative in-frame translation termination codon via a stop codon readthrough mechanism, and that this isoform is localized in the peroxisomes. Mutations in this gene are associated with lactate dehydrogenase B deficiency. Pseudogenes have been identified on chromosomes X, 5 and 13. [provided by RefSeq, Feb 2016]

ENSG00000111716 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000111716 -1.5 1.72e-78 KIRC
ENSG00000111716 -0.9 2.95e-12 BRCA
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000111716 breast cancer 12160330
ENSG00000111716 cancer 12406979
ENSG00000111716 TGCTs 12660824
ENSG00000111716 cancer 12928234
ENSG00000111716 tumors 14578171
ENSG00000111716 prostate cancer 16547507
ENSG00000111716 lung cancer 16890323
ENSG00000111716 lung cancer 17988549
ENSG00000111716 testicular cancer 18489135
ENSG00000111716 cancer 18789002
ENSG00000111716 breast cancers 20495363
ENSG00000111716 bladder tumors 21139803
ENSG00000111716 cancer 21177384
ENSG00000111716 cancer 21199794
ENSG00000111716 cancer 21356207
ENSG00000111716 bladder cancer 21496341
ENSG00000111716 Cancer 21922130
ENSG00000111716 tumour 22027740
ENSG00000111716 tumor 22553414
ENSG00000111716 tumor 22614725
ENSG00000111716 tumor 22752059
ENSG00000111716 tumors 22859959
ENSG00000111716 metastatic colorectal cancer 22991145
ENSG00000111716 triple-negative breast cancer 23139210
ENSG00000111716 tumors 23224736
ENSG00000111716 breast cancer 23437403
ENSG00000111716 tumor 23516535
ENSG00000111716 cancers 23697991
ENSG00000111716 cancer 24023790
ENSG00000111716 tumor 24137329
ENSG00000111716 breast cancer 24280423
ENSG00000111716 tumor 24526833
ENSG00000111716 breast cancer 24639007
ENSG00000111716 cancer 24819061
ENSG00000111716 cancer 25243088
ENSG00000111716 tumour 25266796
ENSG00000111716 tumors 25284964
ENSG00000111716 cancer 25372838
ENSG00000111716 tumors 25501018
ENSG00000111716 breast tumors 25575825
ENSG00000111716 colorectal cancer 25620379
ENSG00000111716 tumor 25652794
ENSG00000111716 pancreatic cancer 25807933
ENSG00000111716 tumour 25907793
ENSG00000111716 tumor 25945836
ENSG00000111716 tumor 25973606
ENSG00000111716 bladder cancer 26087450
ENSG00000111716 tumor 26403591
ENSG00000111716 cancers 26426634
ENSG00000111716 cancer 26469834
ENSG00000111716 cancer 26646448
ENSG00000111716 tumors 26657874
ENSG00000111716 tumor 26735579
ENSG00000111716 tumor 26909082
ENSG00000111716 cancer 26918353
ENSG00000111716 cancer 26993058
ENSG00000111716 cancer 27265680
ENSG00000111716 cancer 27458252
ENSG00000111716 cancer 27509726
ENSG00000111716 cancer 27622334
ENSG00000111716 tumor 27732857
ENSG00000111716 tumor 27802291
ENSG00000111716 tumor 27904684
ENSG00000111716 cancer 28086232
ENSG00000111716 tumor 28756978
ENSG00000111716 GBMs 28804724
ENSG00000111716 tumor 28923827
ENSG00000111716 cancer 28937628
ENSG00000111716 pancreatic cancer 29120638
ENSG00000111716 cancer 29326883
ENSG00000111716 tumor 29377281
ENSG00000111716 breast cancer 29463261
ENSG00000111716 HNSCC 29523854
ENSG00000111716 tumor 29620641
ENSG00000111716 prostate cancer 29891507
ENSG00000111716 cancer 30138330
ENSG00000111716 tumor 30158244
ENSG00000111716 tumors 30419950
ENSG00000111716 tumor 30441870
ENSG00000111716 colorectal cancer 30443978
ENSG00000111716 cervical cancer 30547809
ENSG00000111716 Colorectal Cancer 30745849
ENSG00000111716 liver cancer 30923124
ENSG00000111716 Tumor 31035592
ENSG00000111716 breast tumor 31086659
ENSG00000111716 tumor 31146503
ENSG00000111716 malignant tumors 31180527
ENSG00000111716 tumors 31297336
ENSG00000111716 tumor 31316912
ENSG00000111716 Colorectal Cancer 31424671
ENSG00000111716 tumor 31484939
ENSG00000111716 tumor 31558821
ENSG00000111716 tumor 31660843
ENSG00000111716 tumor 31681589
ENSG00000111716 tumor 31804482
ENSG00000111716 ovarian cancer 3252958
ENSG00000111716 tumour 9066679
ENSG00000111716 cancer 9387317
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000111716 MESO 0.0013 high
ENSG00000111716 HNSC 0.00099 high
ENSG00000111716 READ 0.041 low
ENSG00000111716 LUAD 0.00017 high
ENSG00000111716 THYM 0.012 low
ENSG00000111716 BRCA 0.0098 low
ENSG00000111716 KIRC 0.0048 low
ENSG00000111716 GBM 0.012 low
ENSG00000111716 SKCM 0.016 high
ENSG00000111716 CESC 0.014 low
ENSG00000111716 LIHC 0.0072 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000111716 LUAD Amp 4.859239 0.201046 0.598716 0.304264
ENSG00000111716 LGG Amp 2.942782 0.075536 0.796581 0.091618
ENSG00000111716 PAAD Amp 0.633560 0.078265 0.564629 0.195652
ENSG00000111716 TGCT Amp 20.938490 0.679654 1.778805 0.980000
ENSG00000111716 STAD Amp 0.688077 0.129923 0.623672 0.244898
ENSG00000111716 OV Amp 0.741016 0.328752 0.972532 0.518135