Ensembl ID ENSG00000111667 Gene ID 8078 Accession 12628
Gene Symbol USP5 Alias ISOT Full Name ubiquitin specific peptidase 5
Position 12 : 6852148 - 6866632 Length 14485 bases Strand Plus strand
Status Confidence Main interacting RNAsN.A.RBP type Non-canonical_RBPs
Summary Ubiquitin (see MIM 191339)-dependent proteolysis is a complex pathway of protein metabolism implicated in such diverse cellular functions as maintenance of chromatin structure, receptor function, and degradation of abnormal proteins. A late step of the process involves disassembly of the polyubiquitin chains on degraded proteins into ubiquitin monomers. USP5 disassembles branched polyubiquitin chains by a sequential exo mechanism, starting at the proximal end of the chain (Wilkinson et al., 1995 [PubMed 7578059]).[supplied by OMIM, Mar 2010]

ENSG00000111667 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000111667 USP5 0.75 5.81e-42 BRCA
ENSG00000111667 USP5 1.04 2.67e-44 LUSC
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000111667 USP5 cancer 17205602
ENSG00000111667 USP5 tumour 18601651
ENSG00000111667 USP5 cancer 19098288
ENSG00000111667 USP5 tumor 21976412
ENSG00000111667 USP5 cancer 22084564
ENSG00000111667 USP5 tumor 26912724
ENSG00000111667 USP5 pancreatic cancer 28807830
ENSG00000111667 USP5 pancreatic cancer 29029505
ENSG00000111667 USP5 ovarian tumor 29512757
ENSG00000111667 USP5 non-small cell lung cancer 30555744
ENSG00000111667 USP5 tumor 30809294
ENSG00000111667 USP5 tumor 31281542
ENSG00000111667 USP5 tumor 31371702
ENSG00000111667 USP5 cancer 31410188
ENSG00000111667 USP5 tumor 31452281
ENSG00000111667 USP5 tumor 31645897
ENSG00000111667 USP5 ovarian cancer 31727867
ENSG00000111667 USP5 cancer 31756387
ENSG00000111667 USP5 cancer 31845546
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000111667 USP5 MESO 0.0035 high
ENSG00000111667 USP5 STAD 0.05 low
ENSG00000111667 USP5 UVM 0.00015 high
ENSG00000111667 USP5 PAAD 0.0079 low
ENSG00000111667 USP5 UCEC 0.045 low
ENSG00000111667 USP5 LGG 0.0038 low
ENSG00000111667 USP5 LUSC 0.019 high
ENSG00000111667 USP5 HNSC 0.02 high
ENSG00000111667 USP5 READ 0.047 low
ENSG00000111667 USP5 KIRP 0.032 high
ENSG00000111667 USP5 KICH 0.019 high
ENSG00000111667 USP5 LUAD 0.00017 high
ENSG00000111667 USP5 PCPG 0.0098 high
ENSG00000111667 USP5 THYM 0.0034 low
ENSG00000111667 USP5 COAD 0.036 high
ENSG00000111667 USP5 UCS 0.0048 low
ENSG00000111667 USP5 OV 0.0038 high
ENSG00000111667 USP5 DLBC 0.05 low
ENSG00000111667 USP5 PRAD 0.04 high
ENSG00000111667 USP5 BLCA 0.0014 high
ENSG00000111667 USP5 SKCM 0.00015 high
ENSG00000111667 USP5 LIHC 0.014 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000111667 USP5 LUAD Del 2.237692 0.069659 0.344930 0.248062
ENSG00000111667 USP5 LGG Amp 10.310554 0.153786 0.778452 0.134503
ENSG00000111667 USP5 PAAD Del 1.094191 0.054133 0.396373 0.146739
ENSG00000111667 USP5 OV Amp 1.610720 0.361616 0.907782 0.542314