Ensembl ID
ENSG00000111667
Gene ID
8078
Accession
12628
Gene Symbol
USP5
Alias
ISOT
Full Name
ubiquitin specific peptidase 5
Position
12 : 6852148 - 6866632
Length
14485 bases
Strand
Plus strand
Status
Confidence
Main interacting RNAs N.A. RBP type
Non-canonical_RBPs
Summary
Ubiquitin (see MIM 191339)-dependent proteolysis is a complex pathway of protein metabolism implicated in such diverse cellular functions as maintenance of chromatin structure, receptor function, and degradation of abnormal proteins. A late step of the process involves disassembly of the polyubiquitin chains on degraded proteins into ubiquitin monomers. USP5 disassembles branched polyubiquitin chains by a sequential exo mechanism, starting at the proximal end of the chain (Wilkinson et al., 1995 [PubMed 7578059]).[supplied by OMIM, Mar 2010]
ENSG00000111667 Expression In 33 Tumors
Ensembl ID
Gene symbol
Log2 Foldchange
Pvaue
Cancer
ENSG00000111667
0.75
5.81e-42
BRCA
ENSG00000111667
1.04
2.67e-44
LUSC
Ensembl ID
Gene symbol
Disease/phenotype
Mutation type
Mutated / Total samples
Literature
Ensembl ID
Gene symbol
Cancer
P-value
Which worse
show
ENSG00000111667
MESO
0.0035
high
show
ENSG00000111667
STAD
0.05
low
show
ENSG00000111667
UVM
0.00015
high
show
ENSG00000111667
PAAD
0.0079
low
show
ENSG00000111667
UCEC
0.045
low
show
ENSG00000111667
LGG
0.0038
low
show
ENSG00000111667
LUSC
0.019
high
show
ENSG00000111667
HNSC
0.02
high
show
ENSG00000111667
READ
0.047
low
show
ENSG00000111667
KIRP
0.032
high
show
ENSG00000111667
KICH
0.019
high
show
ENSG00000111667
LUAD
0.00017
high
show
ENSG00000111667
PCPG
0.0098
high
show
ENSG00000111667
THYM
0.0034
low
show
ENSG00000111667
COAD
0.036
high
show
ENSG00000111667
UCS
0.0048
low
show
ENSG00000111667
OV
0.0038
high
show
ENSG00000111667
DLBC
0.05
low
show
ENSG00000111667
PRAD
0.04
high
show
ENSG00000111667
BLCA
0.0014
high
show
ENSG00000111667
SKCM
0.00015
high
show
ENSG00000111667
LIHC
0.014
high
show
Ensembl ID
Gene symbol
Cancer
CNV type
-log10(q-value)
G-score
average amplitude
frequency
ENSG00000111667
LUAD
Del
2.237692
0.069659
0.344930
0.248062
ENSG00000111667
LGG
Amp
10.310554
0.153786
0.778452
0.134503
ENSG00000111667
PAAD
Del
1.094191
0.054133
0.396373
0.146739
ENSG00000111667
OV
Amp
1.610720
0.361616
0.907782
0.542314
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