Ensembl ID ENSG00000111642 Gene ID 1108 Accession 1919
Gene Symbol CHD4 Alias CHD-4;Mi-2b;SIHIWES;Mi2-BETA Full Name chromodomain helicase DNA binding protein 4
Position 12 : 6570082 - 6608430 Length 38349 bases Strand Minus strand
Status Confidence Main interacting RNAsN.A.RBP type Canonical_RBPs
Summary The product of this gene belongs to the SNF2/RAD54 helicase family. It represents the main component of the nucleosome remodeling and deacetylase complex and plays an important role in epigenetic transcriptional repression. Patients with dermatomyositis develop antibodies against this protein. Somatic mutations in this gene are associated with serous endometrial tumors. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014]

ENSG00000111642 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000111642 -0.3 1.95e-16 KIRC
ENSG00000111642 0.48 1.22e-44 BRCA
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000111642 cancer 19835573
ENSG00000111642 cancer 20693977
ENSG00000111642 colorectal cancers 21447119
ENSG00000111642 tumors 22219182
ENSG00000111642 gastric cancers 22496748
ENSG00000111642 endometrial cancer 23104009
ENSG00000111642 cancer 23359684
ENSG00000111642 tumour 23697937
ENSG00000111642 cancer 23708667
ENSG00000111642 tumor 24440720
ENSG00000111642 cancer 25407497
ENSG00000111642 ovarian cancers 25737278
ENSG00000111642 liver cancer 26095183
ENSG00000111642 tumor 26265695
ENSG00000111642 ovarian cancer 26873729
ENSG00000111642 tumour 27443740
ENSG00000111642 liver cancer 27506807
ENSG00000111642 cancer 27631103
ENSG00000111642 breast cancer 27779108
ENSG00000111642 cancer 27791010
ENSG00000111642 endometrial cancer 27997699
ENSG00000111642 cancer 28055972
ENSG00000111642 Tumor 28486105
ENSG00000111642 Malignant Peripheral Nerve Sheath Tumor 28549031
ENSG00000111642 breast cancer 28649742
ENSG00000111642 cancer 28842166
ENSG00000111642 tumor 28940304
ENSG00000111642 tumor 29030609
ENSG00000111642 triple-negative breast cancer 29305962
ENSG00000111642 colorectal cancer 29467924
ENSG00000111642 cancer 29599201
ENSG00000111642 cancer 29667179
ENSG00000111642 cancer 29844320
ENSG00000111642 endometrial cancer 29888111
ENSG00000111642 cancer 29888431
ENSG00000111642 lung cancer 30008631
ENSG00000111642 tumor 30031117
ENSG00000111642 tumor 30043138
ENSG00000111642 tumour 30525090
ENSG00000111642 breast cancer 30563971
ENSG00000111642 tumour 30872624
ENSG00000111642 cancers 30954552
ENSG00000111642 breast cancer 30967373
ENSG00000111642 cancer 31221981
ENSG00000111642 Rectal Cancers 31438571
ENSG00000111642 cancer 31519689
ENSG00000111642 triple-negative breast cancer 31639396
ENSG00000111642 cancer 9790534
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
ENSG00000111642 colon adenocarcinoma conservative_inframe_deletion 7.124% (53/744) 1 entry
ENSG00000111642 colon adenocarcinoma missense_variant 7.124% (53/744) 5 entries
ENSG00000111642 basal cell carcinoma sequence_alteration 20.69% (12/58) 1 entry
ENSG00000111642 colon adenocarcinoma stop_gained 7.124% (53/744) 2 entries
ENSG00000111642 Endometrial Endometrioid Adenocarcinoma missense_variant 7.419% (46/620) 2 entries
ENSG00000111642 colon adenocarcinoma frameshift_variant 7.124% (53/744) 3 entries
ENSG00000111642 colorectal adenocarcinoma missense_variant 9.719% (114/1173) 5 entries
ENSG00000111642 colorectal adenocarcinoma conservative_inframe_deletion 9.719% (114/1173) 1 entry
ENSG00000111642 endometrial carcinoma missense_variant 17.46% (11/63) 2 entries
ENSG00000111642 basal cell carcinoma stop_gained 20.69% (12/58) 1 entry
ENSG00000111642 colorectal adenocarcinoma stop_gained 9.719% (114/1173) 1 entry
ENSG00000111642 colorectal adenocarcinoma sequence_alteration 9.719% (114/1173) 2 entries
ENSG00000111642 basal cell carcinoma missense_variant 20.69% (12/58) 1 entry
ENSG00000111642 gastric adenocarcinoma missense_variant 5.119% (30/586) 3 entries
ENSG00000111642 gastric adenocarcinoma frameshift_variant 5.119% (30/586) 2 entries
ENSG00000111642 Endometrial Endometrioid Adenocarcinoma conservative_inframe_deletion 7.419% (46/620) 1 entry
ENSG00000111642 colorectal adenocarcinoma frameshift_variant 9.719% (114/1173) 2 entries
ENSG00000111642 colon adenocarcinoma sequence_alteration 7.124% (53/744) 4 entries
ENSG00000111642 bladder transitional cell carcinoma missense_variant 2.094% (4/191) 2 entries
ENSG00000111642 nasopharyngeal squamous cell carcinoma missense_variant 1.017% (3/295) 1 entry
ENSG00000111642 melanoma missense_variant 6.931% (7/101) 1 entry
ENSG00000111642 papillary renal cell carcinoma missense_variant 0.8955% (3/335) 1 entry
ENSG00000111642 bile duct adenocarcinoma missense_variant 2.591% (5/193) 1 entry
ENSG00000111642 gastric intestinal type adenocarcinoma missense_variant 4.762% (5/105) 1 entry
ENSG00000111642 papillary thyroid carcinoma missense_variant 0.5063% (2/395) 1 entry
ENSG00000111642 lung adenocarcinoma sequence_alteration 1.718% (20/1164) 1 entry
ENSG00000111642 kidney Wilms tumor missense_variant 1.443% (14/970) 2 entries
ENSG00000111642 prostate carcinoma missense_variant 2.098% (9/429) 3 entries
ENSG00000111642 acute myeloid leukemia missense_variant 0.5513% (5/907) 1 entry
ENSG00000111642 cecum adenocarcinoma missense_variant 7.2% (9/125) 2 entries
ENSG00000111642 head and neck squamous cell carcinoma missense_variant 0.7987% (5/626) 1 entry
ENSG00000111642 rectal adenocarcinoma sequence_alteration 4.082% (10/245) 3 entries
ENSG00000111642 endometrial carcinoma conservative_inframe_deletion 17.46% (11/63) 1 entry
ENSG00000111642 breast carcinoma sequence_alteration 1.733% (25/1443) 1 entry
ENSG00000111642 esophageal adenocarcinoma missense_variant 3.196% (14/438) 1 entry
ENSG00000111642 acute lymphoblastic leukemia missense_variant 1.246% (4/321) 3 entries
ENSG00000111642 ovarian serous adenocarcinoma missense_variant 1.189% (8/673) 1 entry
ENSG00000111642 skin melanoma missense_variant 3.206% (31/967) 3 entries
ENSG00000111642 prostate adenocarcinoma sequence_alteration 1.788% (26/1454) 2 entries
ENSG00000111642 prostate carcinoma sequence_alteration 2.098% (9/429) 1 entry
ENSG00000111642 clear cell renal carcinoma missense_variant 0.7752% (10/1290) 1 entry
ENSG00000111642 Gallbladder Adenocarcinoma sequence_alteration 1.786% (2/112) 1 entry
ENSG00000111642 esophageal squamous cell carcinoma missense_variant 1.185% (8/675) 2 entries
ENSG00000111642 breast ductal adenocarcinoma sequence_alteration 3.474% (23/662) 1 entry
ENSG00000111642 Invasive Breast Carcinoma missense_variant 4.348% (2/46) 1 entry
ENSG00000111642 hepatocellular carcinoma missense_variant 0.8879% (8/901) 1 entry
ENSG00000111642 bladder carcinoma missense_variant 4.685% (26/555) 1 entry
ENSG00000111642 Thyroid Gland Undifferentiated (Anaplastic) Carcinoma missense_variant 1.754% (3/171) 2 entries
ENSG00000111642 gastric intestinal type adenocarcinoma conservative_inframe_deletion 4.762% (5/105) 2 entries
ENSG00000111642 squamous cell lung carcinoma missense_variant 1.706% (13/762) 2 entries
ENSG00000111642 brain glioblastoma missense_variant 0.7559% (7/926) 2 entries
ENSG00000111642 breast ductal adenocarcinoma missense_variant 3.474% (23/662) 1 entry
ENSG00000111642 HER2 Positive Breast Carcinoma missense_variant 2.778% (3/108) 1 entry
ENSG00000111642 endometrium adenocarcinoma missense_variant 11.54% (3/26) 2 entries
ENSG00000111642 lung adenocarcinoma missense_variant 1.718% (20/1164) 5 entries
ENSG00000111642 oral squamous cell carcinoma missense_variant 2.404% (5/208) 2 entries
ENSG00000111642 squamous cell lung carcinoma stop_gained 1.706% (13/762) 2 entries
ENSG00000111642 breast carcinoma missense_variant 1.733% (25/1443) 2 entries
ENSG00000111642 skin melanoma stop_gained 3.206% (31/967) 1 entry
ENSG00000111642 brain glioblastoma sequence_alteration 0.7559% (7/926) 2 entries
ENSG00000111642 skin melanoma sequence_alteration 3.206% (31/967) 1 entry
ENSG00000111642 Ampulla of Vater Carcinoma missense_variant 3.529% (3/85) 1 entry
ENSG00000111642 Uterine Carcinosarcoma missense_variant 7.383% (11/149) 1 entry
ENSG00000111642 female breast carcinoma missense_variant 2.482% (7/282) 4 entries
ENSG00000111642 central nervous system primitive neuroectodermal neoplasm missense_variant 1.126% (5/444) 1 entry
ENSG00000111642 pharyngeal squamous cell carcinoma missense_variant 3.226% (3/93) 2 entries
ENSG00000111642 breast phyllodes tumor missense_variant 3.125% (3/96) 2 entries
ENSG00000111642 esophageal adenocarcinoma sequence_alteration 3.196% (14/438) 1 entry
ENSG00000111642 rectal adenocarcinoma amino_acid_insertion 4.082% (10/245) 2 entries
ENSG00000111642 rectal adenocarcinoma missense_variant 4.082% (10/245) 1 entry
ENSG00000111642 prostate adenocarcinoma missense_variant 1.788% (26/1454) 1 entry
ENSG00000111642 squamous cell lung carcinoma sequence_alteration 1.706% (13/762) 1 entry
ENSG00000111642 Uterine Carcinosarcoma stop_gained 7.383% (11/149) 1 entry
ENSG00000111642 cecum adenocarcinoma frameshift_variant 7.2% (9/125) 1 entry
ENSG00000111642 alveolar rhabdomyosarcoma missense_variant 1.695% (1/59) 1 entry
ENSG00000111642 small cell lung carcinoma missense_variant 0.627% (2/319) 1 entry
ENSG00000111642 Merkel cell skin cancer sequence_alteration 3.333% (1/30) 1 entry
ENSG00000111642 small cell lung carcinoma stop_gained 0.627% (2/319) 1 entry
ENSG00000111642 prostate carcinoma frameshift_variant 2.098% (9/429) 1 entry
ENSG00000111642 Endometrial Clear Cell Adenocarcinoma missense_variant 1.25% (1/80) 1 entry
ENSG00000111642 Cortisol-Producing Adrenal Cortex Adenoma missense_variant 0.8065% (1/124) 1 entry
ENSG00000111642 meningioma (disease) missense_variant 2.041% (1/49) 1 entry
ENSG00000111642 T-cell acute lymphoblastic leukemia missense_variant 0.2632% (1/380) 1 entry
ENSG00000111642 rectal adenocarcinoma conservative_inframe_deletion 4.082% (10/245) 1 entry
ENSG00000111642 Malignant Germ Cell Tumor missense_variant 100.0% (1/1) 1 entry
ENSG00000111642 lung adenocarcinoma stop_gained 1.718% (20/1164) 1 entry
ENSG00000111642 Thymoma Type B3 missense_variant 14.29% (1/7) 1 entry
ENSG00000111642 Gastrointestinal stromal tumor frameshift_variant 9.091% (1/11) 1 entry
ENSG00000111642 ovarian clear cell adenocarcinoma missense_variant 11.11% (1/9) 1 entry
ENSG00000111642 nasopharyngeal squamous cell carcinoma frameshift_variant 1.017% (3/295) 1 entry
ENSG00000111642 kidney Wilms tumor frameshift_variant 1.443% (14/970) 1 entry
ENSG00000111642 colon carcinoma missense_variant 12.5% (1/8) 1 entry
ENSG00000111642 essential thrombocythemia missense_variant 1.639% (1/61) 1 entry
ENSG00000111642 Thyroid Gland Undifferentiated (Anaplastic) Carcinoma sequence_alteration 1.754% (3/171) 1 entry
ENSG00000111642 osteosarcoma missense_variant 1.724% (2/116) 1 entry
ENSG00000111642 melanoma conservative_inframe_deletion 6.931% (7/101) 1 entry
ENSG00000111642 bronchoalveolar adenocarcinoma missense_variant 4.545% (1/22) 1 entry
ENSG00000111642 gastric intestinal type adenocarcinoma stop_gained 4.762% (5/105) 1 entry
ENSG00000111642 cecum adenocarcinoma sequence_alteration 7.2% (9/125) 1 entry
ENSG00000111642 melanoma frameshift_variant 6.931% (7/101) 1 entry
ENSG00000111642 bladder transitional cell carcinoma stop_gained 2.094% (4/191) 1 entry
ENSG00000111642 Benign Adrenal Gland Pheochromocytoma missense_variant 3.03% (1/33) 1 entry
ENSG00000111642 hemangioblastoma conservative_inframe_deletion 10.0% (1/10) 1 entry
ENSG00000111642 head and neck squamous cell carcinoma frameshift_variant 0.7987% (5/626) 1 entry
ENSG00000111642 oral squamous cell carcinoma conservative_inframe_deletion 2.404% (5/208) 1 entry
ENSG00000111642 colonic neoplasm missense_variant 6.667% (1/15) 1 entry
ENSG00000111642 chromophobe renal cell carcinoma missense_variant 0.8696% (1/115) 1 entry
ENSG00000111642 osteosarcoma sequence_alteration 1.724% (2/116) 1 entry
ENSG00000111642 bile duct adenocarcinoma conservative_inframe_deletion 2.591% (5/193) 1 entry
ENSG00000111642 Pancreatic Acinar Cell Carcinoma missense_variant 5.0% (1/20) 1 entry
ENSG00000111642 large cell lung carcinoma missense_variant 5.556% (1/18) 1 entry
ENSG00000111642 endometrium adenocarcinoma frameshift_variant 11.54% (3/26) 1 entry
ENSG00000111642 diffuse large B-cell lymphoma missense_variant 0.3289% (1/304) 1 entry
ENSG00000111642 gastric intestinal type adenocarcinoma frameshift_variant 4.762% (5/105) 1 entry
ENSG00000111642 gastric intestinal type adenocarcinoma sequence_alteration 4.762% (5/105) 1 entry
ENSG00000111642 Brain Stem Glioblastoma missense_variant 1.786% (1/56) 1 entry
ENSG00000111642 bile duct adenocarcinoma frameshift_variant 2.591% (5/193) 1 entry
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000111642 MESO 0.025 high
ENSG00000111642 SARC 0.027 high
ENSG00000111642 UVM 0.011 high
ENSG00000111642 UCEC 0.0093 high
ENSG00000111642 ACC 0.018 low
ENSG00000111642 LGG 0.018 low
ENSG00000111642 HNSC 0.004 high
ENSG00000111642 KIRP 0.0013 high
ENSG00000111642 KICH 0.00039 high
ENSG00000111642 BRCA 0.015 high
ENSG00000111642 COAD 0.0023 high
ENSG00000111642 UCS 0.024 low
ENSG00000111642 KIRC 0.0066 low
ENSG00000111642 LAML 0.0069 low
ENSG00000111642 SKCM 0.0047 high
ENSG00000111642 CESC 0.019 low
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000111642 LUAD Del 2.498917 0.072177 0.347285 0.250000
ENSG00000111642 LGG Amp 10.310554 0.153786 0.778452 0.134503
ENSG00000111642 SARC Del 0.636684 0.117533 0.489990 0.315175
ENSG00000111642 GBM Amp 0.811433 0.069111 0.786861 0.123050
ENSG00000111642 PAAD Del 1.094164 0.054133 0.396373 0.146739
ENSG00000111642 PRAD Del 0.623494 0.070636 0.507756 0.150407
ENSG00000111642 OV Amp 1.806984 0.368069 0.905851 0.547496