Ensembl ID ENSG00000111405 Gene ID 8909 Accession 14369
Gene Symbol ENDOU Alias P11;PP11;PRSS26 Full Name endonuclease, poly(U) specific
Position 12 : 47709734 - 47725567 Length 15834 bases Strand Minus strand
Status Confidence Main interacting RNAssnoRNARBP type Canonical_RBPs
Summary This gene encodes a protein with endoribonuclease activity that binds polyuridine-enriched single-stranded RNA. This gene was initially characterized based on its high expression in placenta but was mischaracterized as a serine protease. In mouse, this gene promotes tolerance to self-antigens by regulating B cell activation-induced cell death (AICD). The protein may be useful as a tumor marker. Multiple alternatively spliced transcript variants encoding distinct protein isoforms have been found for this gene. [provided by RefSeq, Jul 2020]

ENSG00000111405 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000111405 ENDOU -3.4 2.04e-22 HNSC
ENSG00000111405 ENDOU -1.0 4.54e-13 BRCA
ENSG00000111405 ENDOU -4.8 1.67e-21 STAD
ENSG00000111405 ENDOU -1.5 3.61e-20 LUAD
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000111405 ENDOU tumor 18936097
ENSG00000111405 ENDOU tumors 21805647
ENSG00000111405 ENDOU tumor 2350438
ENSG00000111405 ENDOU tumors 2446567
ENSG00000111405 ENDOU cervical cancer 31354287
ENSG00000111405 ENDOU malignant tumours 6160287
ENSG00000111405 ENDOU malignant breast tumors 7036917
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000111405 ENDOU SARC 0.014 low
ENSG00000111405 ENDOU CHOL 0.02 low
ENSG00000111405 ENDOU UVM 0.00011 low
ENSG00000111405 ENDOU PAAD 0.032 high
ENSG00000111405 ENDOU UCEC 0.0098 low
ENSG00000111405 ENDOU ACC 0.0014 low
ENSG00000111405 ENDOU LGG 0.00038 low
ENSG00000111405 ENDOU HNSC 0.00095 low
ENSG00000111405 ENDOU LUAD 0.044 low
ENSG00000111405 ENDOU BRCA 0.023 low
ENSG00000111405 ENDOU COAD 0.05 high
ENSG00000111405 ENDOU UCS 0.015 low
ENSG00000111405 ENDOU KIRC 0.0019 low
ENSG00000111405 ENDOU BLCA 0.047 high
ENSG00000111405 ENDOU LAML 0.014 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000111405 ENDOU LGG Del 1.317776 0.045796 0.445411 0.132554
ENSG00000111405 ENDOU SARC Amp 0.640114 0.254712 0.951907 0.163424
ENSG00000111405 ENDOU GBM Del 1.269777 0.059292 0.485583 0.129983
ENSG00000111405 ENDOU UCEC Amp 2.482514 0.142167 0.661605 0.155844