Ensembl ID
ENSG00000111361
Gene ID
1967
Accession
3257
Gene Symbol
EIF2B1
Alias
VWM1;EIF2B;EIF2BA;EIF2Balpha
Full Name
eukaryotic translation initiation factor 2B subunit alpha
Position
12 : 123620406 - 123633766
Length
13361 bases
Strand
Minus strand
Status
Confidence
Main interacting RNAs mRNA RBP type
Canonical_RBPs
Summary
This gene encodes one of five subunits of eukaryotic translation initiation factor 2B (EIF2B), a GTP exchange factor for eukaryotic initiation factor 2 and an essential regulator for protein synthesis. Mutations in this gene and the genes encoding other EIF2B subunits have been associated with leukoencephalopathy with vanishing white matter. [provided by RefSeq, Oct 2009]
ENSG00000111361 Expression In 33 Tumors
Ensembl ID
Gene symbol
Log2 Foldchange
Pvaue
Cancer
ENSG00000111361
EIF2B1
0.39
5.14e-38
KIRC
ENSG00000111361
EIF2B1
0.42
2.68e-15
LUSC
ENSG00000111361
EIF2B1
0.40
3.34e-12
KIRP
ENSG00000111361
EIF2B1
0.38
1.21e-12
LIHC
ENSG00000111361
EIF2B1
0.39
3.23e-13
LUAD
Ensembl ID
Gene symbol
Cancer types
Pubmed ID
Ensembl ID
Gene symbol
Disease/phenotype
Mutation type
Mutated / Total samples
Literature
Ensembl ID
Gene symbol
Cancer
P-value
Which worse
show
ENSG00000111361
EIF2B1
SARC
0.02
high
show
ENSG00000111361
EIF2B1
LGG
0.00028
high
show
ENSG00000111361
EIF2B1
READ
0.0093
high
show
ENSG00000111361
EIF2B1
LUAD
0.012
high
show
ENSG00000111361
EIF2B1
BRCA
0.002
low
show
ENSG00000111361
EIF2B1
DLBC
0.038
low
show
ENSG00000111361
EIF2B1
PRAD
0.0034
high
show
ENSG00000111361
EIF2B1
TGCT
0.039
low
show
ENSG00000111361
EIF2B1
LAML
0.012
high
show
Ensembl ID
Gene symbol
Cancer
CNV type
-log10(q-value)
G-score
average amplitude
frequency
ENSG00000111361
EIF2B1
LUAD
Del
0.714905
0.051405
0.279720
0.236434
ENSG00000111361
EIF2B1
UCS
Del
0.770659
0.206863
0.491962
0.321429
ENSG00000111361
EIF2B1
PAAD
Del
1.194446
0.055898
0.347525
0.217391
ENSG00000111361
EIF2B1
LIHC
Del
2.789650
0.096268
0.444103
0.154054
ENSG00000111361
EIF2B1
BRCA
Del
4.887810
0.092025
0.380378
0.196296
ENSG00000111361
EIF2B1
UCEC
Del
2.175085
0.065080
0.403094
0.122449
ENSG00000111361
EIF2B1
OV
Del
4.657486
0.242334
0.572097
0.329879
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