Ensembl ID ENSG00000111144 Gene ID 4048 Accession 6710
Gene Symbol LTA4H Alias NA Full Name leukotriene A4 hydrolase
Position 12 : 96000753 - 96043520 Length 42768 bases Strand Minus strand
Status Confidence Main interacting RNAsN.A.RBP type Non-canonical_RBPs
Summary The protein encoded by this gene is an enzyme that contains both hydrolase and aminopeptidase activities. The hydrolase activity is used in the final step of the biosynthesis of leukotriene B4, a proinflammatory mediator. The aminopeptidase activity has been shown to degrade proline-glycine-proline (PGP), a neutrophil chemoattractant and biomarker for chronic obstructive pulmonary disease (COPD). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]

ENSG00000111144 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000111144 LTA4H -1.7 1.52e-98 LUSC
ENSG00000111144 LTA4H -0.8 1.12e-17 LUAD
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000111144 LTA4H tumor 12865451
ENSG00000111144 LTA4H tumour 1362255
ENSG00000111144 LTA4H cancer 15134534
ENSG00000111144 LTA4H tumour 17298411
ENSG00000111144 LTA4H AML 17976189
ENSG00000111144 LTA4H tumors 18591367
ENSG00000111144 LTA4H colon cancer 19531649
ENSG00000111144 LTA4H tumor 19919819
ENSG00000111144 LTA4H pancreatic cancer 20952510
ENSG00000111144 LTA4H prostate cancer 21308720
ENSG00000111144 LTA4H cancers 21991341
ENSG00000111144 LTA4H cancer 24385243
ENSG00000111144 LTA4H tumor 25072959
ENSG00000111144 LTA4H tumor 26663781
ENSG00000111144 LTA4H colorectal cancer 28065501
ENSG00000111144 LTA4H skin cancer 28575166
ENSG00000111144 LTA4H tumour 28891085
ENSG00000111144 LTA4H cancer 30058075
ENSG00000111144 LTA4H tumor 30185791
ENSG00000111144 LTA4H colorectal cancer 31085102
ENSG00000111144 LTA4H tumour 8615763
ENSG00000111144 LTA4H lung cancers 8918363
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000111144 LTA4H SARC 0.036 low
ENSG00000111144 LTA4H PAAD 0.006 low
ENSG00000111144 LTA4H THCA 6e-04 high
ENSG00000111144 LTA4H ACC 0.029 high
ENSG00000111144 LTA4H LGG 0.0015 high
ENSG00000111144 LTA4H HNSC 0.024 high
ENSG00000111144 LTA4H READ 0.013 low
ENSG00000111144 LTA4H KIRP 0.039 high
ENSG00000111144 LTA4H LUAD 0.00035 low
ENSG00000111144 LTA4H THYM 0.00095 low
ENSG00000111144 LTA4H BRCA 0.00086 high
ENSG00000111144 LTA4H UCS 0.011 low
ENSG00000111144 LTA4H OV 0.0091 high
ENSG00000111144 LTA4H DLBC 0.041 low
ENSG00000111144 LTA4H BLCA 0.00015 high
ENSG00000111144 LTA4H LAML 0.0023 high
ENSG00000111144 LTA4H GBM 0.012 high
ENSG00000111144 LTA4H SKCM 0.027 low
ENSG00000111144 LTA4H LIHC 0.012 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000111144 LTA4H SARC Amp 4.314166 0.428104 0.941172 0.245136
ENSG00000111144 LTA4H PAAD Del 1.566020 0.062958 0.356155 0.233696
ENSG00000111144 LTA4H SKCM Del 1.324529 0.076700 0.429475 0.247956
ENSG00000111144 LTA4H BRCA Del 0.638314 0.062653 0.390126 0.165741
ENSG00000111144 LTA4H PRAD Amp 1.117396 0.052078 0.546339 0.069106
ENSG00000111144 LTA4H OV Del 2.815707 0.216530 0.565423 0.326425